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Preparation method and application of targeted mercuric sulfide nanoparticle medicine

A nanoparticle, mercury sulfide technology, applied in the directions of pharmaceutical formulations, drug combinations, drug delivery, etc., to achieve the effects of simple process, good stability, and easy control of process conditions

Active Publication Date: 2021-08-27
INNER MONGOLIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drug can effectively treat psoriasis to a certain extent, its pharmacodynamic mechanism and toxicity have always been the focus of clinical application and new drug development.

Method used

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  • Preparation method and application of targeted mercuric sulfide nanoparticle medicine
  • Preparation method and application of targeted mercuric sulfide nanoparticle medicine
  • Preparation method and application of targeted mercuric sulfide nanoparticle medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 A kind of preparation method of targeted mercury sulfide nanoparticle medicine

[0045] This embodiment is a preparation method of targeted mercury sulfide nanoparticle medicine, which is prepared by a one-pot method, and is carried out in sequence according to the following steps:

[0046] (11) At 25°C, add 32.5 mg of mercury nitrate into the reduced glutathione solution under vigorous stirring (dissolve the reduced glutathione in purified water in advance, stir vigorously until dissolved), and the stirring speed is 1500rad / s, the stirring time is 20min, the mass ratio of reduced glutathione to mercuric nitrate is 2:1, and the pH is adjusted to 7 with sodium hydroxide to obtain A;

[0047] (12) At 25°C, pass N into A 2 (N 2 The flow rate is 0.03-0.04m 3 / s), and drip sodium sulfide solution (concentration is 1.5mol / L, the mass ratio of sodium sulfide and mercuric nitrate is 1:1250) with the speed of 0.1mL / min in A, after dropping, stop feeding Nitrogen,...

Embodiment 2-4

[0050] The preparation method of embodiment 2-4 targeting type mercury sulfide nanoparticles medicine

[0051] Examples 2-4 are respectively a preparation method of targeted mercury sulfide nanoparticle medicine, the preparation process is similar to that of Example 1, the only difference is that the corresponding technical parameters in the preparation process are different, see the table below for details.

[0052]

[0053]

Embodiment 5

[0054] Embodiment 5 effect test

[0055] The targeted mercury sulfide nanoparticle drugs prepared in Examples 1-4 can be applied to the treatment of psoriasis. In this example, performance experiments will be conducted on the mercury sulfide nanoparticles prepared in the present invention.

[0056] (1) In vitro active oxygen test

[0057] The present invention has carried out in vitro active oxygen test to the mercuric sulfide nanoparticle prepared in embodiment 1-4, and the process of testing adopts prior art means, through in vitro experiment, adds H to the mercuric sulfide nanoparticle solution 2 o 2 , the test results show that the mercuric sulfide nanoparticles prepared by the present invention will have the characteristics of quantum dot aggregation under the action of active oxygen, figure 1 Figure (b) in the middle is the scanning electron microscope image of the sample prepared in Example 1 of the present invention under the action of active oxygen. It can be seen ...

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Abstract

The invention discloses a preparation method of a targeted mercuric sulfide nanoparticle medicine. Mercuric sulfide nanoparticles are prepared by applying a one-pot method and taking mercuric nitrate and sodium sulfide as raw materials and reducing glutathione as a protective agent and a modifier, the whole preparation process is simple, the process is controllable, the period is short, the prepared mercuric sulfide nanoparticles are uniform in particle size, the particle size is within 12nm, the skin targeting effect is realized in the practical application of psoriasis treatment, the acting time of the medicine on the skin surface is remarkably prolonged, and the toxic and side effects of the medicine on non-targeting parts are greatly reduced. The preparation method is suitable for preparing the targeted mercuric sulfide nano-particle medicine, and further preparing a gel ointment containing the targeted mercuric sulfide nano-particle medicine.

Description

technical field [0001] The invention belongs to the field of nano Mongolian medicine, and relates to the preparation and application of a targeted mercury sulfide nanoparticle medicine. Background technique [0002] Psoriasis is a common type of immune-related chronic relapsing inflammatory skin disease in dermatology. It is clearly stated in Mongolian Medicine and Surgery that psoriasis belongs to the category of "yellow water disease" (that is, the category of "Xieri Wusu"). The treatment of Mongolian medicine is based on the principle of syndrome differentiation combined with the cause of the disease and the evolution of the course of the disease, to dry the yellow water and eliminate the symptoms of skin lesions. "Menggenwusu" (namely: mercury) is a commonly used mineral Mongolian medicine in Mongolian medicine. Its main components are HgS and elemental sulfur. The medicine is pungent, cold, heavy, and highly toxic. Worm, dry pus and blood, the effect of eliminating car...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/28A61K9/51A61K9/06A61K47/64A61P17/06
CPCA61K33/28A61K9/5169A61K9/06A61K47/32A61K9/0014A61P17/06
Inventor 武世奎王得慧何春龙张慧文王焕芸吴斌崔鸿江王敏杰陈建平赵向东臧慧敏王敏王灿李思睿康淑霞姚尧乔琪刑天娇
Owner INNER MONGOLIA MEDICAL UNIV