Method for deducing submerging time of corpses in water after early death based on metabonomics markers and application of method
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A technology of metabolomics data and markers, which is applied in the field of marker screening for inferring the submergence time of early corpses in water, can solve rare problems and achieve the effects of high contribution, close correlation and high predictive ability
Active Publication Date: 2021-09-03
中国医科大学
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[0004] To sum up, research on the early PMSI inference of corpses in water is relatively rare, and the method of inferring the early submersion time of corpses in water is an urgent problem to be solved
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Embodiment 1
[0031] 1. Research object and grouping.
[0032] Training set: 80 male SD rats were randomly divided into drowning group (group D, T1-40) and postmortem submersion group (group PS, T41-80), with 40 rats in each group. The rats in the drowning group were immersed in river water (natural fresh water) and drowned, and the rats in the water group were taken with CO 2 After being asphyxiated by gas, they were immersed in river water, and the temperature of the river water was 20-25°C during the experiment. Heart blood (about 200 μL) was extracted at different time points (0h, 6h, 12h, 18h and 24h) after immersion in water after death, and 8 rat corpses were taken at each time point, and the samples were immediately placed in liquid nitrogen after collection. Then store at -80°C for future inspection.
[0033] Test set: 20 male SD rats were randomly divided into drowning group (V1-10) and postmortem submersion group (V11-20), with 10 rats in each group. The corpses of dead animal...
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Abstract
The invention belongs to the technical field of forensic medicine and biological medicine, and particularly relates to application of metabonomics in deducing submerging time of a corpse in water after early death. The marker for deducing the submerging time of the dead body in water is any one or a combination of more than one of the following 19 small molecule metabolites which are slightly influenced by the dead cause: epinephrine, cis-aconitic acid, citric acid, 1,2,3-cyclopropane tricarboxylic acid, riboflavin, citraconic acid, 4-acetylbutyric acid, D-glucosamine 6-phosphoric acid, phosphoenolpyruvic acid, 1-methyladenosine, 3-phosphoglyceric acid, creatine, carnosine, pyruvic acid, beta-alanine, 1, 5-diaminopentane, pantothenic acid, allantoin and 2-dimethylaminoguanosine. According to the method for deducing the submerged time of the dead corpse in the water based on the metabonomics marker, the early PMSI of the corpse in the water can be deduced conveniently and accurately, the influence of different causes of death and the judgment error of human subjective factors are greatly reduced, and more favorable help is expected to be provided for case detection in forensic practice.
Description
technical field [0001] The invention belongs to the technical fields of forensic science and biomedicine, and in particular relates to a marker screening method for estimating the submersion time of corpses in water after early death and the application thereof. Background technique [0002] The time of death, also known as the postmortem interval (PMI, postmortem interval), refers to the time interval from the death of the corpse to the forensic examination. The time of death inference essentially infers the elapsed or interval time after death. Accurate inference of PMI is of great significance for determining the time of crime, delineating the scope of investigation and determining the nature of the case, and it is one of the important problems to be solved in forensic identification. The environment of the body after death is an important factor affecting the inference of the time of death. Compared with land, the environment in water is more complex and changeable, so...
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