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A kind of afterglow monitoring slow-release antibacterial zinc germanate matrix nanomaterial and preparation method thereof

A nanomaterial, zinc germanate technology, applied in luminescent materials, nanotechnology for materials and surface science, antibacterial drugs, etc., can solve the problems of difficult real-time monitoring of antibacterial process, difficult treatment of infected parts, chronic wounds, etc. Achieve the effects of no pollution in the preparation process, wide application range and low cost

Active Publication Date: 2022-08-09
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, although some smart wound dressings developed through integrated sensors can treat infected wounds by real-time monitoring of wound temperature, pH, blood oxygen level and body fluid markers, etc. The antibacterial process in the complex biological environment of the infection site is difficult to achieve real-time monitoring, which brings certain difficulties to the follow-up and timely further treatment of the infection site
If the bacteria are not eradicated in time, the infected site may develop into a chronic wound, and there is even a risk of amputation and death

Method used

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  • A kind of afterglow monitoring slow-release antibacterial zinc germanate matrix nanomaterial and preparation method thereof
  • A kind of afterglow monitoring slow-release antibacterial zinc germanate matrix nanomaterial and preparation method thereof
  • A kind of afterglow monitoring slow-release antibacterial zinc germanate matrix nanomaterial and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation method of a zinc zinc -rayate matrix antibacterial nanomaterial, the preparation steps are as follows:

[0053] (1) GE 4+ Preparation of ammonia aquatic solution: Geo 2 After adding the superponement of the powder in the water, stir it, add the mass ammonia water with a mass percentage of 28 % to the powder to the powder, and the fixed capacity will be obtained by 0.4mol·L -1 GE 4+ Ammonia water solution;

[0054] (2) Zn (NO 3 Cure 2 Preparation of the aquatic solution: Zn (NO 3 Cure 2 · 6H 2 O solid and ultra -pure water mixes until the solid is completely dissolved and fixed to obtain the required concentration solution;

[0055] (3) CU (NO 3 Cure 2 Preparation of aquatic solution: CU (NO 3 Cure 2 · 3H 2 O solid and ultra -pure water mixes until the solid is completely dissolved and fixed to obtain the required concentration solution;

[0056] (4) Zn (NO) obtained by step (2) 3 Cure 2 Aquatic solution, step (3) CU (NO 3 Cure 2 Water solution, 0.3ml concent...

Embodiment 2

[0067] (1) Same Example 1;

[0068] (2) Same Example 1;

[0069] (3) Same Example 1;

[0070] (4) Zn (NO) obtained by step (2) 3 Cure 2 Aquatic solution, step (3) CU (NO 3 Cure 2 Water solution, 0.3ml concentrated nitric acid is added to 11ml ultra -pure water, mix and mix well, add the step (1) to get one by one (1) 4+ Ammonia aquatic solution, where ZN 2+ , GE 4+ , CU 2+ The Moore is 2: 1: 0.005, and the pH value of ammonia water with a mass percentage concentration of 28 % is 28 %. The pH value of the hybrid solution to 9.0 is placed in the ultrasonic solution in the ultrasonic cleaning machine for 10 minutes, and then the magnetic force is stirred at room temperature for 1 hour;

[0071] (5) The mixed solution obtained from the step (4) is transferred to the stainless steel high -pressure kettle of polytetrafluoroethylene, reacting in a 160 ° C oven for 8 hours;

[0072] (6) Same Example 1;

[0073] (7) Same Example 1.

Embodiment 3

[0075] (1) Same Example 1;

[0076] (2) Same Example 1;

[0077] (3) Same Example 1;

[0078] (4) Zn (NO) obtained by step (2) 3 Cure 2 Aquatic solution, step (3) CU (NO 3 Cure 2 Water solution, 0.3ml concentrated nitric acid is added to 11ml ultra -pure water, mix and mix well, add the step (1) to get one by one (1) 4+ Ammonia aquatic solution, where ZN 2+ , GE 4+ , CU 2+The Moore is 2: 1: 0.01, and the pH value of ammonia water with a mass percentage concentration of 28 % is 28 %. The pH value of the hybrid solution to 9.0 is placed in the ultrasonic solution in the ultrasonic cleaner for 10 minutes, and then the magnetic force is stirred at room temperature for 1 hour;

[0079] (5) The mixed solution obtained from the step (4) is transferred to the stainless steel high -pressure kettle of polytetrafluoroethylene, reacts in the 120 ° C oven for 24 hours;

[0080] (6) Same Example 1;

[0081] (7) Same Example 1.

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Abstract

The invention discloses a zinc germanate matrix nanomaterial capable of afterglow monitoring slow-release antibacterial and a preparation method thereof, belonging to the field of preparation of antibacterial nanomaterials. The general formula of the chemical composition of the zinc germanate matrix antibacterial nanomaterial of the present invention is Zn 2 GeO 4 : xM, 0.001≤x≤0.02, where Zn 2 GeO 4 is the matrix, M is the metal ion with antibacterial effect. The zinc germanate matrix antibacterial nanomaterial in the invention is synthesized by hydrothermal method, the preparation is simple, the cost is low, and it can be used for industrial production; the material has excellent broad-spectrum antibacterial performance at the bacterial infection site, and the sustained release of metal ions can maintain a high level for a long time. The antibacterial concentration is long, the antibacterial period is long, and the possibility of inducing bacteria to develop drug resistance is extremely small; in the slightly acidic environment of the bacterial infection site, the afterglow intensity of the material changes with the degradation of the material, and the change of the remaining glow intensity can be used to achieve infection. Real-time monitoring of site antimicrobial processes.

Description

Technical field [0001] The invention involves a zinc -rayate matrix matrix material and preparation method that can monitor the mittering antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial antibacterial. Background technique [0002] Bacterial infections have become one of the largest public health problems in the world, and millions of people die from bacterial infections each year. Since the discovery of penicillin in 1982, a variety of antibiotics have been developed and have been widely used to cope with bacterial infections. Excessive use of antibiotics causes bacteria to resist, which causes multi -drug bacteria or even super bacteria. Since the peak period of R & D in the 1980s, the research and development speed of antibiotics has slowed year by year. The new type of antibiotics approved after 2000 is a handful, which has caused tremendous pressure on the treatment of bacterial infections. Fortunately, the emergence of nanomaterials brings...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/02A61K49/00A61K33/06A61K33/24A61K33/26A61K33/32A61K33/34A61K33/38A61P17/02A61P31/04B82Y5/00B82Y20/00B82Y30/00B82Y40/00C09K11/58
CPCC09K11/584A61K9/143A61K47/02A61K49/0015A61K49/0093A61K33/38A61K33/34A61K33/24A61K33/26A61K33/32A61K33/06A61P31/04A61P17/02B82Y5/00B82Y20/00B82Y30/00B82Y40/00Y02A50/30
Inventor 陈丽建严秀平龚嘉华王江悦刘瑶瑶
Owner JIANGNAN UNIV