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Composite adhesive for granulating traditional Chinese medicine extract

A technology for compounding adhesives and extracts, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. Safety and safety, easy granulation and drying effect

Active Publication Date: 2021-09-28
珠海天凯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of composite binder for Chinese medicine extract granulation, this composite binder can make Chinese medicine extract easy to granulate, solves the problem of traditional Chinese medicine extract The problem that the granulation process is not easy to form, and the prepared granules have good moisture resistance, which is conducive to the storage of granules and improves the stability of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A kind of composite adhesive for Chinese medicine extract granulation, its composition is as shown in table 1:

[0020] The composition table of table 1 embodiment 1

[0021] Name of raw material Weight (g) Absolute ethanol 1000.0 Povidone 1.0 twain 0.1 stearic acid 100.0

[0022] The composite adhesive is made according to the following method: add absolute ethanol into the container, slowly add povidone and stearic acid under stirring state, after the dissolution is complete, add Tween, stir for 10 minutes until uniform, dry and granulate Instantly.

[0023] The application method of this composite adhesive in the granulation process of ginseng extract is as follows: take 5 Kg of ginseng extract and place it in a high-efficiency wet granulator, and redissolve the composite adhesive of this embodiment with absolute ethanol to obtain a composite adhesive Add the mixture solution into a granulator, granulate for 5 minutes, granula...

Embodiment 2

[0033] A kind of composite adhesive for Chinese medicine extract granulation, its composition is as shown in table 3:

[0034] The composition table of table 3 embodiment 2

[0035] Name of raw material Weight (g) acetone 1000.0 Povidone 0.5 Ethyl cellulose 0.5 twain 0.12 stearic acid 100.0

[0036] The composite adhesive is made according to the following method: add acetone to the container, slowly add povidone, ethyl cellulose and stearic acid under stirring state, after the dissolution is complete, add Tween, stir for 10 minutes until uniform, Dry granulation to obtain composite binder.

[0037] The application method of the composite binder in the granulation process of the Radix Notoginseng extract is as follows: take 5Kg of the Radix Notoginseng extract and put it in a high-efficiency wet granulator, redissolve the composite binder of this embodiment with acetone to obtain a composite binder The solution is added into a gra...

Embodiment 3

[0047] A kind of composite adhesive for Chinese medicine extract granulation, its composition is as shown in table 5:

[0048] The composition table of table 5 embodiment 3

[0049] Name of raw material Weight (g) Dichloromethane 1000.0 hypromellose 1.0 talcum powder 0.15 hydrogenated vegetable oil 100.0

[0050] The composite adhesive is made according to the following method: put dichloromethane into the container, slowly add hydrogenated vegetable oil and hypromellose under stirring, add talcum powder after the dissolution is complete, stir for 10 minutes until uniform, and dry to prepare pellets to obtain a composite adhesive.

[0051] The application method of the composite adhesive in the granulation process of the Sargassum extract is as follows: get 5Kg of the Sargassum extract and put it in a high-efficiency wet granulator, and the composite adhesive of the present embodiment is redissolved with dichloromethane The composite bi...

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Abstract

The invention belongs to the technical field of moisture prevention of traditional Chinese medicine extract granulation, and particularly relates to a composite adhesive for a traditional Chinese medicine extract granulation. The composite adhesive is composed of an adhesive, a lubricant and a waxy material. The composite adhesive can reduce surface tension of particles, forms a film on surfaces of the particles by utilizing the waxy material, synergistically plays a role in resisting moisture in air, and reduces hygroscopicity of the particles, so that the particles are not easy to adhere and agglomerate in a granulation or drying process, the prepared particles are not easy to damp, the traditional Chinese medicine extract is easy to granulate and dry, subsequent capsule filling or tabletting process is facilitated, storage of particles is facilitated, and stability and safety of medicine are improved.

Description

technical field [0001] The invention relates to the technical field of moisture-proofing of traditional Chinese medicine preparations, in particular to a composite binder used for granulating Chinese medicine extracts. Background technique [0002] Chinese medicine extract is an important intermediate in the production of Chinese medicine preparations, and its quality plays a decisive role in the subsequent molding process of Chinese medicine preparations and the quality and curative effect of the finished preparations. However, most traditional Chinese medicine extracts containing polysaccharides often have poor fluidity and increased viscosity due to moisture absorption during the production and preparation process, resulting in agglomeration, agglomeration, etc., and it is difficult to make granules, and further cannot be further made into capsules or tablets. Chinese medicine extracts tend to form lumps or adhere to the surface of pharmaceutical equipment after moisture ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/32A61K47/38A61K47/26A61K47/22A61K47/12A61K47/02A61K47/04A61K47/44A61K47/14A61K36/258A61K36/185A61K31/7024
CPCA61K9/1635A61K9/1652A61K9/1617A61K9/1623A61K9/1611A61K36/258A61K36/185A61K31/7024
Inventor 麦耀权张晓明周序诚谭垚婷黄家俊沈黎江冯婉仪
Owner 珠海天凯生物科技有限公司