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Carbamazepine pharmaceutical composition as well as preparation method and application thereof

A technology of carbamazepine and a composition, which is applied in the field of carbamazepine pharmaceutical composition and its preparation, can solve the problems of anemia and malnutrition, electrolyte disturbance, life-threatening and the like, and achieves the advantages of long-term treatment, promotion of digestion and absorption, The effect of promoting gastrointestinal motility

Inactive Publication Date: 2021-09-28
JIANGSU PENGYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Severe diarrhea leads to dehydration, electrolyte imbalance and acidosis, causing serious damage to the body. If not rescued in time, it may be life-threatening

Method used

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  • Carbamazepine pharmaceutical composition as well as preparation method and application thereof

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preparation example Construction

[0029] Second aspect, the embodiment of the present invention also provides a kind of preparation method of carbamazepine pharmaceutical composition, it comprises the following steps:

[0030] 1. Mix carbamazepine, hydroxypropyl cellulose and crospovidone evenly, add water to granulate.

[0031] Specifically, it includes: first crush carbamazepine to 100-120 mesh, put carbamazepine, crospovidone, hydroxypropyl cellulose, starch, cottonseed peptide, and L-arabinose into a wet granulator, mix, add Appropriate amount of purified water, granulated. Wet granulation is carried out with a oscillating granulator, and the mesh size of the screen is 12 to 14 mesh. Wet granules are placed in a high-efficiency boiling dryer, preheated at an inlet temperature of 60-70°C for 10 minutes, and dried at room temperature to control the moisture content of the granules between 2-6%. The dried granules are sized in a swing granulator, and the mesh size of the sieve is 16-18 mesh. Reserve after ...

Embodiment 1

[0038] Present embodiment provides a kind of carbamazepine pharmaceutical composition, and its preparation method is as follows:

[0039] 1. Preparation materials: 120g carbamazepine, 50g hydroxypropyl cellulose, 100g crospovidone, 100g sodium lauryl sulfate, 240g cottonseed peptide.

[0040] 2. Granulation: crush carbamazepine to 120 mesh; put carbamazepine, hydroxypropyl cellulose, starch and crospovidone in a wet granulator, mix for 5 minutes, add an appropriate amount of purified water, and granulate 2 minutes. Wet sizing is carried out with a oscillating granulator, and the mesh number of the sieve is 12 mesh. Wet granules are placed in a high-efficiency boiling dryer, and the dryer is preheated with wind at a temperature of 70°C for 10 minutes, and then dried at room temperature. Control particle moisture at around 2%. The dried granules are sized in a swing granulator, and the mesh number of the sieve is 16 mesh. Reserve after whole grain. Then add sodium lauryl su...

Embodiment 2

[0042] Present embodiment provides a kind of carbamazepine pharmaceutical composition, and its preparation method is as follows:

[0043] 1. Raw materials: 80g carbamazepine, 100g hydroxypropyl cellulose, 50g crospovidone, 50 parts sodium lauryl sulfate, 360g cottonseed peptide and 20g gastric soluble film coating premix.

[0044] 2. Granulation: crush carbamazepine to 100 mesh; put carbamazepine, hydroxypropyl cellulose, starch and crospovidone in a wet granulator, mix for 6 minutes, add an appropriate amount of purified water, and granulate 1 minute. Wet sizing is carried out with a oscillating granulator, and the mesh number of the sieve is 14 mesh. Wet granules are placed in a high-efficiency boiling dryer, and the dryer is preheated with wind at a temperature of 60°C for 15 minutes, and then dried at room temperature. Control particle moisture at about 6%. The dried granules are sized in a swing granulator, and the mesh size of the sieve is 18 mesh. Reserve after whol...

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Abstract

The invention discloses a carbamazepine pharmaceutical composition. The carbamazepine pharmaceutical composition is prepared from the following components in parts by weight: 80 to 120 parts of carbamazepine, 50 to 100 parts of hydroxypropyl cellulose, 50 to 100 parts of polyvinylpolypyrrolidone, 10 to 50 parts of sodium dodecyl sulfate, 240 to 360 parts of cottonseed peptide and 160 to 240 parts of L-arabinose. A preparation method of the carbamazepine pharmaceutical composition comprises the following steps: uniformly mixing the carbamazepine, the hydroxypropyl cellulose, the polyvinylpolypyrrolidone, the cottonseed peptide and the L-arabinose; adding water and carrying out granulating; then adding the sodium dodecyl sulfate; and after uniform mixing, preparing a tablet. According to the carbamazepine pharmaceutical composition disclosed by the invention, a medicine can be slowly released in a body and direct stimulation of the carbamazepine on gastrointestinal tracts is reduced, so that side effects, especially occurrence of serious gastrointestinal tract reactions, are reduced; and effective blood concentration is maintained and the compliance and safety of medication of patients are improved, so that the patients can easily tolerate the medicine and long-period treatment is facilitated.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a carbamazepine pharmaceutical composition and its preparation method and application. Background technique [0002] Carbamazepine is an antiepileptic drug, but very large doses of carbamazepine can cause diarrhea in individual patients. When diarrhea exceeds 5 times a day or bloody diarrhea occurs, it is generally necessary to reduce the drug dose or stop carbamazepine immediately and treat it in time. Generally, after the drug is stopped, the treatment will be difficult to proceed smoothly, thereby affecting the curative effect of the treatment. The main cause of diarrhea in patients receiving carbamazepine is the direct inhibition or destruction of intestinal mucosal cells by the drug. Complications of diarrhea: 1. Water and electrolyte disturbance. A large amount of water and electrolytes will be lost during diarrhea. If they are not replenished in time and effectively, wa...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61K47/38A61K47/32A61K47/20A61K47/42A61K47/26A61K9/20A61P25/08
CPCA61K31/55A61K47/38A61K47/32A61K47/20A61K47/42A61K47/26A61K9/2063A61K9/2054A61K9/2027A61K9/2013A61K9/2018A61P25/08
Inventor 周健蒋锋扶文君王顺陆光炜张添程
Owner JIANGSU PENGYAO PHARMA
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