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Size-controllable MXene-coated BSA nano diagnosis and treatment agent and preparation and application thereof

A nano-size technology, applied in the field of biomedical nanomaterials, can solve the problems of poor penetration matching and high biological toxicity, and achieve the effects of easy functionalization, good biocompatibility, and improved biocompatibility

Active Publication Date: 2021-10-01
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to provide a size-controllable MXene@BSA nano-therapeutic agent and its preparation method to solve the problems of poor penetration matching between existing MXene particle size and tumor site and high biological toxicity

Method used

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  • Size-controllable MXene-coated BSA nano diagnosis and treatment agent and preparation and application thereof
  • Size-controllable MXene-coated BSA nano diagnosis and treatment agent and preparation and application thereof
  • Size-controllable MXene-coated BSA nano diagnosis and treatment agent and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Weigh 1g LiF, slowly add it into 30mL of 9M HCl solution, keep stirring for 20min, then slowly add 0.8gTi 3 AlC 2 , Stirring was continued at 30°C for 30h.

[0050] The solid obtained from the above reaction was repeatedly centrifuged and washed with water until the pH of the supernatant after centrifugation was ≥ 6. The solid was collected in a vacuum drying oven and dried at 60°C for 24 hours to obtain a multilayer Ti 3 C 2 Material is solid.

[0051] Add 0.8g multilayer Ti to 150mL water 3 C 2 The material was placed in a JT-240T ultrasonic cleaner (40KHz, 150W), and after ultrasonic treatment for 4h under argon protection, it was centrifuged at a speed of 3000r / min for 1.5h, and the dark supernatant was collected to obtain a thin layer of MXene (Ti 3 C 2 ) solution, denoted as TM-1, the concentration of the measured solution is 6mg / mL.

[0052] Measure 6mL thin layer MXene (Ti 3 C 2 ) solution, using a SONICS VCX130PB / VCX130 ultrasonic probe crusher, crushi...

Embodiment 2

[0058] Weigh 1.6g LiF, slowly add it into 20mL of 9M HCl solution, keep stirring for 30min, then slowly add 1.0g Ti 3 AlC 2 , Stirring was continued at 45°C for 24h.

[0059] The solid obtained from the above reaction was repeatedly centrifuged and washed with water until the pH of the supernatant after centrifugation was ≥ 6. The solid was collected in a vacuum drying oven and dried at 60°C for 24 hours to obtain a multilayer Ti 3 C 2 Material is solid.

[0060] Add 0.8g multilayer Ti to 200mL water 3 C 2 The material was placed in a JT-240T ultrasonic cleaner (40KHz, 150W), and after ultrasonic treatment for 3h under argon protection, it was centrifuged at a speed of 3500r / min for 1h, and the dark supernatant was collected to obtain a thin layer of MXene (Ti 3 C 2 ) solution, denoted as TM-2, the concentration of the measured solution is 5mg / mL.

[0061] Measure 5mL thin layer MXene (Ti 3 C 2 ) solution, using a SONICS VCX130PB / VCX130 ultrasonic probe crusher, crush...

Embodiment 3

[0067] Weigh 0.8g LiF, slowly add it into 10mL of 9M HCl solution, keep stirring for 10min, then slowly add 0.5Ti 3 AlC 2 , Stirring was continued at 50°C for 30h.

[0068]The solid obtained from the above reaction was repeatedly centrifuged and washed with water until the pH of the supernatant after centrifugation was ≥ 6. The solid was collected in a vacuum drying oven and dried at 60°C for 36 hours to obtain a multilayer Ti 3 C 2 Material is solid.

[0069] Add 0.4g multilayer Ti to 100mL water 3 C 2 The material was placed in a JT-240T ultrasonic cleaner (40KHz, 150W), and after ultrasonic treatment for 5h under argon protection, it was centrifuged at a speed of 3500r / min for 1h, and the dark supernatant was collected to obtain a thin layer of MXene (Ti 3 C 2 ) solution, denoted as TM-3, the concentration of the measured solution is 3mg / mL.

[0070] Measure 3mL thin layer MXene(Ti 3 C 2 ) solution, using a SONICS VCX130PB / VCX130 ultrasonic probe crusher, crushing ...

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Abstract

The invention discloses a size-controllable MXene-coated BSA nano diagnosis and treatment agent and a preparation method thereof. The preparation method comprises the steps that firstly, a MAX-phase Ti3AlC2 material is etched and stripped into a large-size thin-layer MXene material Ti3C2 through a chemical etching and ultrasonic-assisted stripping technology, then the nano size of the Ti3C2 is regulated and controlled through an ultrasonic probe crusher, finally, the Ti3C2 with a certain nano size is wrapped with BSA, the biocompatibility of the nano diagnosis and treatment agent is improved, the MXene coated BSA nano diagnosis and treatment agent with the adjustable particle size in the range of 30-200nm is obtained, not only are the problems that the existing MXene particle size is poor in penetration matching with a tumor site and the biotoxicity is high solved, but also the function of integrating PAI imaging and photothermal therapy diagnosis and treatment in an NIR-II window with deeper penetration depth is achieved, and the response interval of PAI imaging of the Ti3C2 MXene nano diagnosis and treatment agent is widened.

Description

technical field [0001] The invention belongs to the technical field of biomedical nanomaterials, and relates to a nano-diagnosis agent that can be used for the integration of tumor diagnosis and treatment, in particular to a size-controllable MXene@BSA nano-diagnosis agent and a preparation method thereof. Background technique [0002] Cancer remains by far the leading cause of death in all countries and the most important barrier to increasing life expectancy. "Prevention, early diagnosis, and early treatment" are the keys to the continuous decline in cancer incidence and mortality in the past 40 years (CA-Cancer. J. Clin. 2018, 68: 7-30.). [0003] However, there is still a lack of clinical methods for early diagnosis and treatment of tumors. Traditional imaging methods such as X-ray, ultrasound, CT, MRI, and PET are difficult to locate and characterize early tumors, and the existing clinical treatment methods are mostly radiotherapy and chemotherapy with severe side effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/14A61K49/18A61K49/22A61K41/00A61K47/42A61K47/02A61P35/00
CPCA61K49/143A61K49/1869A61K49/221A61K49/225A61K41/0052A61K47/42A61K47/02A61P35/00
Inventor 康建民
Owner SHANXI MEDICAL UNIV
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