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Preparation and application of anti-PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) components in Eurya chinensis

A rice broken flower and virus technology, applied in the preparation of medical preparations containing active ingredients, antiviral agents, organic compounds, etc., can solve the problem of unsatisfactory protective effects of inactivated vaccines, loose poison of attenuated vaccines, and strong virulence and other problems, to achieve significant anti-PRRSV virus effect, low price, and easy-to-obtain raw materials

Inactive Publication Date: 2021-10-19
SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the PRRSV vaccines on the market mainly include inactivated vaccines and attenuated vaccines, but the protective effect of inactivated vaccines is not ideal. The attenuated vaccines have the risk of loosening the virus, and the virulence may return to strong during the immunization process.

Method used

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  • Preparation and application of anti-PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) components in Eurya chinensis
  • Preparation and application of anti-PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) components in Eurya chinensis
  • Preparation and application of anti-PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) components in Eurya chinensis

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The separation preparation and structural characteristics of four kinds of compounds of embodiment 1

[0033] 23Kg of broken rice flowers and leaves are dried and crushed, extracted with 95% industrial alcohol, repeated three times, soaked for 96 hours for the first time, soaked for 72 hours for the second and third times, concentrated three times with a large rotary evaporator under reduced pressure, and combined and concentrated to obtain the initial extract. Mix the initial extract with pure water, stir well to suspend it, add the same volume of ethyl acetate, stir vigorously, layer in a 5000mL separatory funnel, let it stand for 30 minutes, and collect the layered parts sequentially according to the layering order , concentrated the ethyl acetate fraction under reduced pressure and repeated extraction of the aqueous fraction with ethyl acetate three times. The concentrated products of the ethyl acetate fractions were combined and weighed to obtain 1.7 Kg of the eth...

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Abstract

The invention relates to the technical field of medicines, provides antiviral application of eurya chinensis, and particularly relates to preparation and application of anti-PRRSV components in Eurya chinensis. It is discovered for the first time through in-vitro antiviral experiments that compounds such as Betulinic acid, alpha-amyrin, taxifolin and hydroxytyrosol extracted and separated from Eurya chinensis R.Br. have anti-PRRSV activity, so that new safe plants and the new natural compounds are provided for the preparation of a drug for treating the porcine reproductive and respiratory syndrome virus, and a powerful technical support is provided for the preparation of a drug or a drug composition for treating the porcine reproductive and respiratory syndrome virus. The Eurya chinensis has good antiviral activity and contains antiviral active components. The Eurya chinensis is used as both medicine and food, and has very high market economic value.

Description

technical field [0001] The invention relates to an antiviral application of broken rice flowers, in particular to the preparation and application of anti-PRRSV virus components in broken rice flowers. Background technique [0002] Porcine Reproductive and Respiratory Syndrome (Porcine Reproductive and Respiratory Syndrome, PRRS) is a kind of infection pig fever, anorexia, late abortion, premature birth, stillbirth, weak fetus and mummified fetus in pregnant sows, pigs of various ages (especially Piglets) is a highly contagious disease characterized by respiratory disturbances. Pig PRRS spreads fast, especially in technologically advanced and economically developed countries, where pigs are densely populated and flow frequently, making it more likely to cause epidemics. After a severe epidemic period, the disease is often endemic, endangering pig production for a long time and causing huge economic losses to the pig industry. The disease was first reported in the United Sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00C07D311/32C07D311/40C07C39/11C07C37/68C07C37/82A61P31/14A61K31/56A61K31/353A61K31/05A61K36/82
CPCC07J63/008C07D311/32C07D311/40C07C39/11C07C37/004A61P31/14A61K36/82A61K2236/333A61K2236/17A61K2236/39A61K2236/53A61K2236/55
Inventor 徐明行韦珊珊姚丽媛杜逸琼秦绪兵林婷婷
Owner SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI
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