Fiber membrane with multilayer structure as well as preparation method and application of fiber membrane

Abstract

The invention provides a fiber membrane with a multilayer structure as well as a preparation method and application thereof. The preparation method of the fiber membrane comprises the following steps of (1) carrying out electrostatic spinning on a solution of a spinning material to obtain a layer of fiber membrane; (2) changing the distance between spinneret orifices and corresponding rollers, and carrying out electrostatic spinning on the layer of fiber membrane obtained in the step (1) to obtain a fiber membrane with a two-layer structure; and (3) optionally repeating the step (2) to obtain the fiber membrane with the multilayer structure, wherein the distances between the spinneret orifices and the corresponding rollers in two adjacent electrostatic spinning are different; the number of layers of the fiber membrane with the multilayer structure is n, and n is greater than or equal to 2; and the operation frequency of the step (2) is n-1. Compared with a hot pressing process, the method is easy to operate, mechanical property loss of the material caused by hot pressing can be avoided, and by selecting the degradable material as the spinning material, the spinning material prepared through the method has excellent mechanical property and good compatibility and can be used in soft tissue repair materials.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a fiber membrane and its preparation method and application. Background technique [0002] Soft tissue is an important tissue in the human body. Soft tissue injury caused by surgery, trauma, disease and other reasons has become one of the common clinical diseases and seriously threatens human health. Therefore, soft tissue repair and treatment is particularly important. Soft tissue repair is a long process, and the implanted materials need to have high mechanical strength throughout the repair process, such as abdominal wall defect, inguinal hernia, Achilles tendon repair, etc., which require high-strength materials to provide certain support for the repair process. The main material currently used for the above diseases is woven mesh. However, although the woven mesh has good mechanical properties, it has defects such as high hardness, rough surface, easy adhes...

AI Technical Summary

Problems solved by technology

However, the connection between the fiber membranes is directly carried out by means of thermocompression bonding, which easily destroys the structure of the fiber membranes, resulting in a decrease in the repair performance of the electrospun membrane and a loss of mechanical strength, and an ideal composite membrane cannot be obtained; CN1586637A discloses a double-layer membrane Composite collagen-based guided tissue regeneration material and its preparation method, it uses collagen and hyaluronic acid or its sodium salt as main raw materials, and prepares a double-layer composite guided tissue with dense layer and loose layer structure through mechanical pressing and chemical cross-linking Recycled membrane material

Although the multilayer structure membrane material has the function of guiding tissue regeneration, due to the limitations of its main material itself (such as collagen needs to be purified and cross-linked, and the source is unstable) and the defects of the molding process (such as the membrane surface is completely dense and non-porous , the composite between layers needs to be mechanically pressed or used chemical crosslinking agent) so that these membrane materials are affected in clinical use

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