Small-size calcium phosphate fiber as well as preparation method and application thereof

Abstract

The invention discloses a small-size calcium phosphate fiber, as well as a preparation method thereof and the application of the small-size calcium phosphate fiber in preparation of a medicine for repairing fracture. The preparation method comprises the following steps: completely dissolving polyvinyl alcohol in deionized water at 90-100 DEG C, and then cooling to normal temperature to obtain a solution A, the mass concentration of polyvinyl alcohol in the solution A being 0.5-1%; dispersing amorphous calcium phosphate of which the size is less than 3nm into absolute ethyl alcohol to obtain a mixed solution B, wherein the concentration of the calcium phosphate in the mixed solution B is 5-20mg / mL; dissolving arginine in deionized water at normal temperature to obtain a solution C, wherein the mass concentration of the arginine in the solution C is 0.5-3%; under stirring, dropwise adding the mixed solution B and the solution C into the solution A, uniformly mixing, performing ultrasonic treatment for 20-40 minutes after dropwise adding is completed, finally performing air drying at normal temperature to form a thin film, and screwing the thin film to obtain the small-size calcium phosphate fiber. The volume ratio of the mixed solution B to the solution C to the solution A is 1: 1: 1.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a small-sized calcium phosphate fiber and its preparation method and application. Background technique [0002] Fracture refers to a typical disease in which the integrity and continuity of bone or cartilage tissue is interrupted when the bone or cartilage tissue is subjected to violence, resulting in bone dysfunction. Severe fractures can lead to complications such as shock, which can even be life-threatening. [0003] If a fracture occurs due to a mild external force collision due to a disease of the bone itself, such as tuberculosis, osteomyelitis or osteoma, it is called a pathological fracture. Fractures mostly occur in children and the elderly, while the incidence rate of young and middle-aged people is relatively low. [0004] The methods for the general treatment of fractures mainly include: open reduction and clamping bone fixation. These two are currently more co...

AI Technical Summary

Problems solved by technology

But they also have disadvantages: such as pain for the patient, and the possibility of recurrence when the fixation falls off, thereby increasing financial revenue and expenditure

Commonly used calcium phosphate-based repair materials are mainly crystalline hydroxyapatite, which is large in size and cannot be used to repair fractures from the root

Images