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Purification production process of galanthamine

A technology of galantamine and production process, which is applied in the field of galantamine purification, can solve the problems of serious environmental pollution and high production cost, and achieve the effects of high purity, transparent production cost, and good separation and extraction effect

Inactive Publication Date: 2021-11-05
怀化市盛德生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The chemical synthesis of alkaloids such as galantamine in Lycoris has been reported, but extraction from Lycoris plants is still an important source of such substances. The extraction methods of Lycoris alkaloids in the prior art mainly include solvent Extraction method, ultrasonic extraction method, microwave extraction method, supercritical fluid extraction and other methods, these methods generally have the disadvantages of serious environmental pollution and high production cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of galantamine purification production process of the present invention comprises steps as follows:

[0026] Raw material preparation:

[0027] Step 1: Grinding the dried lycoris into powder with a pulverizer to obtain lycoris powder;

[0028] The crude product extraction process of galantamine:

[0029] Step 2: Put the dry Lycoris powder into the extraction kettle, the dosage of Lycoris powder is 1 / 4 of the volume of the extraction kettle, and then add methanol to the extraction kettle to soak the Lycoris powder, the amount of methanol added is 1 / 4 of the volume of the extraction kettle. The garlic powder is 10 centimeters higher, and the methanol used is industrial methanol with a content of 90%;

[0030] Step 3: Open the valve at the bottom of the extraction kettle, put the methanol soaked in the lycoris powder in the extraction kettle into the concentration kettle, and at the same time open the steam valve of the concentration kettle to concentrate and refl...

Embodiment 2

[0044] A kind of galantamine purification production process of the present invention comprises steps as follows:

[0045] Raw material preparation:

[0046] Step 1: Grinding the dried lycoris into powder with a pulverizer to obtain lycoris powder;

[0047] The crude product extraction process of galantamine:

[0048] Step 2: Put the dry Lycoris powder into the extraction kettle, the dosage of Lycoris powder is 1 / 4 of the volume of the extraction kettle, and then add methanol to the extraction kettle to soak the Lycoris powder, the amount of methanol added is 1 / 4 of the volume of the extraction kettle. The garlic powder is 30 centimeters higher, and the methanol used is industrial methanol with a content of 90%;

[0049] Step 3: Open the valve at the bottom of the extraction kettle, put the methanol soaked in the lycoris powder in the extraction kettle into the concentration kettle, and at the same time open the steam valve of the concentration kettle to concentrate and refl...

Embodiment 3

[0063] A kind of galantamine purification production process of the present invention comprises steps as follows:

[0064] Raw material preparation:

[0065] Step 1: Grinding the dried lycoris into powder with a pulverizer to obtain lycoris powder;

[0066] The crude product extraction process of galantamine:

[0067] Step 2: Put the dry Lycoris powder into the extraction kettle, the dosage of Lycoris powder is 1 / 4 of the volume of the extraction kettle, and then add methanol to the extraction kettle to soak the Lycoris powder, the amount of methanol added is 1 / 4 of the volume of the extraction kettle. Garlic powder is 20 cm higher, and the methanol used is industrial methanol with a content of 90%;

[0068] Step 3: Open the valve at the bottom of the extraction kettle, put the methanol soaked in the lycoris powder in the extraction kettle into the concentration kettle, and at the same time open the steam valve of the concentration kettle to concentrate and reflux, concentra...

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Abstract

The invention relates to a purification production process for galanthamine. According to the purification production process provided by the invention, galanthamine is purified from lycoris radiata plants; crude extraction and fine extraction are mainly included in the process; used main raw materials comprise lycoris radiata, methanol, chloroform, dichloromethane, chromatographic silica gel, absolute ethyl alcohol and hydrobromic acid; only equipment such as an extraction kettle and a concentration kettle is needed; and thus, the raw materials are convenient to obtain, equipment investment is low, operation is convenient, separation and extraction effect on galanthamine is good, the purity of an extracted product is high, production cost is low, and the process is suitable for industrial and large-scale production.

Description

technical field [0001] The invention relates to the technical field of galantamine purification methods, in particular to a galantamine purification production process. Background technique [0002] Galantamine is a tetracyclic alkaloid isolated from the plant Galanthus woronowi for the first time in 1952, and belongs to the reversible cholinesterase inhibitor. It is characterized by being easy to pass through the blood-brain barrier and has a strong neurological effect. Small doses of galantamine have a strong inhibitory effect on the activity of cholinesterase in the cerebral cortex and medulla, while large doses can inhibit the activity of cholinesterase in the thalamus. Galantamine is used in the treatment of polio and various neurological diseases, but mainly in the treatment of glaucoma and as an antidote after the use of curare. In recent years, the use of galantamine in the treatment of Alzheimer's disease and vascular dementia, the treatment of alcohol dependence ...

Claims

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Application Information

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IPC IPC(8): C07D491/107
CPCC07D491/107C07B2200/13C07B2200/07
Inventor 周春杨志平孙伟胥雯
Owner 怀化市盛德生物科技有限责任公司
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