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Application of diosgenin in preparation of medicine for relieving neuralgia caused by oxaliplatin

A technology of diosgenin and oxaliplatin, which is applied in the field of medicine, can solve problems such as cold stimulation allergy, allodynia, and paresthesia, and achieve the effect of alleviating neuralgia, wide sources, and low toxic and side effects

Pending Publication Date: 2021-11-12
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in up to 90% of cases, irreversible peripheral neuropathy (chemotherapy induced peripheral neuropathy, CIPN) occurs during or after oxaliplatin treatment, which severely limits its clinical application in tumor chemotherapy, mainly manifested as Paresthesia, allodynia, hyperalgesia, cold stimulus hypersensitivity, gunshot or electric shock, etc.
However, the mechanism of oxaliplatin-induced neuralgia is not clear, and there is no effective drug for clinical treatment, and a drug is urgently needed to relieve the pain.

Method used

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  • Application of diosgenin in preparation of medicine for relieving neuralgia caused by oxaliplatin
  • Application of diosgenin in preparation of medicine for relieving neuralgia caused by oxaliplatin
  • Application of diosgenin in preparation of medicine for relieving neuralgia caused by oxaliplatin

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Embodiment Construction

[0011] Diosgenin, molecular formula is C 27 h 42 o 3 , molecular weight is 414.63, white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. CAS number: 512-04-9, the structural formula is shown in formula I:

[0012]

[0013] The present invention will be further described below by specific examples.

[0014] 1. Experimental method

[0015] 1.1 Model establishment and drug administration

[0016] Six-week-old male C57BL / 6 mice were randomly divided into normal group, model group and diosgenin group (8 mice in each group). All mice had free access to food and water, and the ambient temperature was (20±2)°C. The model group and the diosgenin group received continuous intraperitoneal injection of oxaliplatin (3.0 mg / kg, dissolved in 5% glucose injection) once a day for 5 days, rested for 5 days, and repeated administration for 5 days. The total cumulative amount of oxaliplatin reached 30mg / kg. The normal group was injected intraperitoneal...

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Abstract

The invention discloses application of diosgenin in preparation of a medicine for relieving neuralgia caused by oxaliplatin, and experiments prove that the diosgenin can improve mechanical and cold stimulation abnormal pain caused by oxaliplatin.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the use of diosgenin in the preparation of medicines for relieving neuralgia caused by oxaliplatin. Background technique [0002] Diosgenin is a hydrolyzed product of diosgenin, which is widely found in plants such as yams, lilies, and pinks. According to traditional Chinese medicine, diosgenin has the effects of eliminating phlegm, promoting diuresis, relaxing tendons and activating blood circulation. Modern pharmacological research shows that diosgenin has many pharmacological effects, and is used to treat cancer, hyperlipidemia, inflammation and infection, and has low toxic and side effects, so it is widely used. In recent years, a large number of research reports have found that diosgenin can be used to prevent and treat neurological diseases, including Alzheimer's disease, neuroinflammation, spinal cord injury and neuropathic pain caused by diabetes. [0003] Oxaliplati...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P25/00
CPCA61K31/58A61P25/00
Inventor 高文远满淑丽刘轩硕
Owner TIANJIN UNIV
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