Application of diosgenin in preparation of medicine for relieving neuralgia caused by oxaliplatin
A technology of diosgenin and oxaliplatin, which is applied in the field of medicine, can solve problems such as cold stimulation allergy, allodynia, and paresthesia, and achieve the effect of alleviating neuralgia, wide sources, and low toxic and side effects
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[0011] Diosgenin, molecular formula is C 27 h 42 o 3 , molecular weight is 414.63, white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. CAS number: 512-04-9, the structural formula is shown in formula I:
[0012]
[0013] The present invention will be further described below by specific examples.
[0014] 1. Experimental method
[0015] 1.1 Model establishment and drug administration
[0016] Six-week-old male C57BL / 6 mice were randomly divided into normal group, model group and diosgenin group (8 mice in each group). All mice had free access to food and water, and the ambient temperature was (20±2)°C. The model group and the diosgenin group received continuous intraperitoneal injection of oxaliplatin (3.0 mg / kg, dissolved in 5% glucose injection) once a day for 5 days, rested for 5 days, and repeated administration for 5 days. The total cumulative amount of oxaliplatin reached 30mg / kg. The normal group was injected intraperitoneal...
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