A kind of polyacrylonitrile fiber with biological activity and preparation method thereof

A polyacrylonitrile fiber, bioactive technology, applied in fiber processing, fiber type, textile and papermaking, etc., can solve the limited effect of modified polyacrylonitrile fiber biocompatibility and increase the risk of implant-related complications , limit the application value of modified polyacrylonitrile fibers, etc., to achieve the effect of stable and efficient reaction system, conducive to directional growth and functional expression, and reducing the residue of toxic substances

Active Publication Date: 2022-07-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) If the reaction temperature is too high, it will have a strong destructive effect on the structure of collagen, which will affect the application value of collagen in soft tissue repair; (2) Toxic and harmful chemical reagents are used in the reaction system and are difficult to remove. Potential toxic and side effects have been brought to the modified polyacrylonitrile fiber, which limits the application value of the modified polyacrylonitrile fiber in the biomedical neighborhood; (3) Collagen grafting modified polyacrylonitrile fiber (4) Some polyacrylonitrile modified materials use bioinert materials, so cells cannot adhere and regenerate, and long-term storage in the body will increase implant-related complications risk of disease

Method used

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  • A kind of polyacrylonitrile fiber with biological activity and preparation method thereof
  • A kind of polyacrylonitrile fiber with biological activity and preparation method thereof
  • A kind of polyacrylonitrile fiber with biological activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) With polyacrylonitrile (PAN) fiber: NaOH: NaHCO 3 =3:0.7:0.3 mass ratio to weigh PAN fiber, NaOH and NaHCO respectively 3 , weigh 3g of PAN fibers with a linear density of 2.22 to 5.55dtex and place them in a 500mL three-necked flask, weigh 0.7g of NaOH and 0.3g of NaHCO 3 Prepare an alkaline solution with a concentration of 1%, add it into a three-necked flask equipped with PAN fiber, start the stirrer, select a stirring speed of 60-100 r / min, heat up to 85-95 ° C, and condense and reflux for 48-72 h, so that After the reaction is completed, the sample is cooled to room temperature, washed with a large amount of water, acidified with a hydrochloric acid solution, washed with a large amount of water, and freeze-dried to obtain a hydrolyzed PAN fiber sample.

[0049] (2) The Na 2 HPO 4 ·2H 2 O, NaH 2 PO 4 , 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), N-hydroxysuccinimide (NHS) dissolved in water at 20℃~25℃ Mix well, the concentration of ...

Embodiment 2

[0052] (1) With polyacrylonitrile (PAN) fiber: NaOH: NaHCO 3 =3:0.7:0.3 mass ratio to weigh PAN fiber, NaOH and NaHCO respectively 3 , weigh 3g of PAN fibers with a linear density of 2.22 to 5.55dtex and place them in a 500mL three-necked flask, weigh 0.7g of NaOH and 0.3g of NaHCO 3 Prepare an alkaline solution with a concentration of 1%, add it into a three-necked flask equipped with PAN fiber, start the stirrer, select a stirring speed of 60-100 r / min, heat up to 85-95 ° C, and condense and reflux for 48-72 h, so that After the reaction is completed, the sample is cooled to room temperature, washed with a large amount of water, acidified with a hydrochloric acid solution, washed with a large amount of water, and freeze-dried to obtain a hydrolyzed PAN fiber sample.

[0053] (2) The Na 2 HPO 4 ·2H 2 O, NaH 2 PO 4 , 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), N-hydroxysuccinimide (NHS) dissolved in water at 20℃~25℃ Mix well, the concentration of ...

Embodiment 3

[0056] (1) With polyacrylonitrile (PAN) fiber: NaOH: NaHCO 3 =3:0.7:0.3 mass ratio to weigh PAN fiber, NaOH and NaHCO respectively 3 , weigh 3g of PAN fibers with a linear density of 2.22 to 5.55dtex and place them in a 500mL three-necked flask, weigh 0.7g of NaOH and 0.3g of NaHCO 3 Prepare an alkaline solution with a concentration of 1%, add it into a three-necked flask equipped with PAN fiber, start the stirrer, select a stirring speed of 60-100 r / min, heat up to 85-95 ° C, and condense and reflux for 48-72 h, so that After the reaction is completed, the sample is cooled to room temperature, washed with a large amount of water, acidified with a hydrochloric acid solution, washed with a large amount of water, and freeze-dried to obtain a hydrolyzed PAN fiber sample.

[0057] (2) The Na 2 HPO 4 ·2H 2 O, NaH 2 PO 4 , 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), N-hydroxysuccinimide (NHS) dissolved in water at 20℃~25℃ Mix well, the concentration of ...

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Abstract

The invention discloses a polyacrylonitrile fiber with biological activity, which is prepared by the following method: after hydrolyzing the polyacrylonitrile fiber in an alkaline solution, it is mixed with a collagen aqueous solution and a cross-linking solution, the pH value is adjusted, and chemical modification is carried out. 2~72h; the raw material of the alkaline solution includes NaHCO 3 , NaOH and water; the raw materials of the cross-linking solution include a cross-linking agent, a buffer substance and water; the collagen-modified polyacrylonitrile fiber contains collagen and polyacrylonitrile. The polyacrylonitrile fiber prepared by the method of the invention maintains the good natural structure of collagen, can better promote the adhesion and proliferation of fibroblasts, is conducive to the directional growth and functional expression of fibroblasts, and has good biocompatibility, The mechanical properties are beneficial to the repair of soft tissue, and are especially suitable for the mechanical strength requirements such as abdominal wall defects.

Description

technical field [0001] The invention relates to the field of tissue engineering, in particular to a biologically active polyacrylonitrile fiber and a preparation method thereof. Background technique [0002] As early as 1894, the French chemist Moreau first proposed the synthesis of polyacrylonitrile (PAN). Due to the influence of World War II, the industrial production of polyacrylonitrile fiber was not until 1950 by the German I.G.Farbenindustrie Company and the American DuPont. The company realized that the German trade name is Perlon, and the American trade name is Orlon. Since the introduction of the first polyacrylonitrile fiber production line in my country in the 1970s, the production research of polyacrylonitrile fiber has developed rapidly. At present, my country has almost all the process routes for the production of polyacrylonitrile fiber in the world. According to customs data, my country only imported 149,500 tons of various polyacrylonitrile fibers in 2018, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D06M11/38D06M11/71D06M11/76D06M13/332D06M13/352D06M15/15D06M101/28
CPCD06M15/15D06M11/76D06M11/38D06M11/71D06M13/332D06M13/352D06M2101/28
Inventor 王永杨世炜林海
Owner SICHUAN UNIV
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