A kind of extraction process of ginkgolide

A technique for extracting ginkgolides, which is applied in the field of extraction techniques for ginkgolides, can solve the problems of increasing the production process, not being suitable for large-scale production, and unsafe organic solvents, etc., achieving significant economic benefits, reducing losses, and reducing The effect of production costs

Active Publication Date: 2022-04-12
南京久安源环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mainly have the following defects: (1) The amount of organic solvent is large, the cost of raw materials is high, and the organic solvent is unsafe. All electrical equipment in the extraction workshop must adopt explosion-proof grades, which greatly increases the cost; (2) Use petroleum ether extraction or deacidification resin to remove ginkgo biloba acid, increase the production process, high production cost, and introduce impurities; (3) many steps, long route, low product purity and low yield; (4) serious pollution and severe environmental problems
(5) It is not suitable for large-scale production, and the unit output cost is high

Method used

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  • A kind of extraction process of ginkgolide
  • A kind of extraction process of ginkgolide
  • A kind of extraction process of ginkgolide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1: according to such as figure 2 The flow chart for the extraction of ginkgolides is shown:

[0067] (1) Ginkgo biloba is crushed to 20 meshes, leached with 60% ethanol solution at 50-80° C., and extracted 6 times to obtain the crude extract of ginkgo biloba;

[0068] (2) The crude extract obtained in step (1) is evaporated and concentrated, and after being concentrated 6 times, the Ginkgo biloba extract concentrate is obtained, and ethanol is recovered simultaneously;

[0069] (3) centrifuging the ginkgo leaf extract concentrate obtained in step (2) at 6000rpm / min disc centrifuge for 10min to obtain the ginkgo extract centrifugate, the content of ginkgolide is 0.15%, and the impurity content is 5.3%;

[0070] (4) After the ginkgo extract centrifugate obtained by step (3) is filtered and clarified through the ceramic ultrafiltration membrane after activation and modification, after impurity removal, the ceramic membrane filtrate is obtained, the content of ...

Embodiment 2

[0083] Embodiment 2: according to as figure 2 The flow chart for the extraction of ginkgolides is shown:

[0084] (1) Ginkgo biloba is crushed to 5 meshes, extracted with 60% ethanol solution at 50-80° C., and extracted 6 times to obtain the crude extract of ginkgo biloba;

[0085] (2) The crude extract obtained in step (1) is evaporated and concentrated, and after being concentrated 6 times, the Ginkgo biloba extract concentrate is obtained, and ethanol is recovered simultaneously;

[0086] (3) the ginkgo leaf extract concentrate that step (2) is obtained is centrifuged through a 6000rpm / min disc centrifuge for 10min to obtain the ginkgo extract centrifugate, the content of ginkgolide is 0.15%, and the impurity content is 5.5%;

[0087] (4) obtaining the ceramic membrane filtrate after the ginkgo extract centrifugate obtained in step (3) is filtered and clarified by activated modified ceramic ultrafiltration membrane, and impurities are removed, the content of ginkgolide is...

Embodiment 3

[0100] Embodiment 3: according to such as figure 2 The flow chart for the extraction of ginkgolides is shown:

[0101] (1) Ginkgo biloba is crushed to 40 meshes, extracted with 60% ethanol solution at 50-80° C., and extracted 6 times to obtain the crude extract of Ginkgo biloba;

[0102] (2) The crude extract obtained in step (1) is evaporated and concentrated, and after being concentrated 6 times, the Ginkgo biloba extract concentrate is obtained, and ethanol is recovered simultaneously;

[0103] (3) the ginkgo leaf extract concentrated solution that step (2) is obtained is centrifuged 10min through 8000rpm / min disc centrifuge, obtains ginkgo extract centrifugate, the content of ginkgolide is 0.16%, and impurity content is 5.6%;

[0104] (4) after the ginkgo extract centrifugate obtained by step (3) is filtered and clarified through the ceramic ultrafiltration membrane after the activation modification, after impurity removal, obtain such as image 3 In the shown ceramic m...

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Abstract

The invention discloses a process for extracting ginkgolides, which comprises the following steps: (1) filtering the ginkgo extract through a ceramic membrane activated by an organic acid to obtain a ceramic membrane filtrate; (2) subjecting the ceramic membrane filtrate to the following process conditions (2i) extraction; (2ii) adsorption, desorption; (2iii) concentration through nanofiltration membrane nanofiltration; (2iv) evaporation; (2v) crystallization; (2vi) )dry. The ceramic membrane adopted in the present invention not only can withstand high temperature, high pressure, chemical corrosion, and has a long service life, but also adopts the ceramic membrane after activation treatment, which can effectively filter and remove suspended solids, colloids, and macromolecular plant proteins, improve product quality, and reduce Turbidity, increase yield.

Description

technical field [0001] The invention belongs to the field of natural medicine extraction, and in particular relates to an extraction process of ginkgolide. Background technique [0002] Ginkgo biloba is the dry leaf of Ginkgo biloba L. Harvest in autumn when leaves are still green and dry in time. It is generally artificially cultivated, and the cultivation area reaches Liaoning in the north, Guangdong in the south, Zhejiang in the east, Shaanxi and Gansu in the west, and Sichuan, Guizhou, and Yunnan in the southwest. It has the effects of promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, astringing the lungs and relieving asthma, reducing turbidity and reducing fat. For blood stasis blocking collaterals, chest obstruction and heartache, apoplexy hemiplegia, lung deficiency cough and asthma, hyperlipidemia. Ginko Biloba Extract (GBE) is a type of product enriched in active ingredients extracted from ginkgo leaves as raw materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/22
CPCC07D493/22
Inventor 褚斌刘怀红陈磊张南南李国学方威
Owner 南京久安源环保科技有限公司
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