Sedative for children and preparation method thereof

Abstract

The invention provides a sedative for children and a preparation method thereof, and belongs to the field of medicines. The sedative (a chloral hydrate solution) for children comprises the following raw materials: a chloral hydrate raw material medicine and a grease solvent, and the mass ratio of the chloral hydrate raw material medicine to the grease solvent can be (10-32): (68-90), specifically 10: 90, 20: 80 or 30: 70. The grease solvent can be selected from one or more of soybean oil, corn oil, sunflower seed oil, tea oil, sesame oil, olive oil, peanut oil, medium-chain triglyceride, triethyl glyceride, oleic acid grease and oleic acid, and specifically can be a mixture of soybean oil and sunflower seed oil in a mass ratio of 10: 1; and the sedative for children can further comprise vitamin E. The sedative (chloral hydrate solution) for children is prepared by using the grease solvent instead of water, the grease solvent has better solubility for chloral hydrate and can ensure the stability of chloral hydrate, and the stability of chloral hydrate is further enhanced by adding vitamin E.

Description

technical field [0001] The invention relates to a sedative for children and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Chloral hydrate is a hydrate of chloral, a hypnotic, anticonvulsant, white or colorless transparent crystal; irritating, very smelly, slightly bitter taste; gradually volatilizes in the air. Has sedative, hypnotic and anticonvulsant effects. The hypnotic mechanism may be similar to barbiturates, causing approximate physiological sleep without obvious aftereffects. Larger doses have anticonvulsant effects, and large doses can cause coma and anesthesia. Chloral hydrate is not easy to accumulate and poison in the body, and the usual amount has no toxic effect. It is highly irritating and should be applied after dilution. [0003] At present, the main clinical uses are 1. Treatment of insomnia, suitable for patients with difficulty falling asleep. As a hypnotic, short-term application is effective, and co...

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Problems solved by technology

[0005] The stability of chloral hydrate solution is affected by storage time, storage conditions and temperature. Light and long-term storage should be avoided, and it should be stored at low temperature. , when chloral hydrate is clinically used for children, the dosage needs to be adjusted according to the body weight, but because of its poor stability, pharmaceutical companies cannot develop oral solutions according to the technical requirements of the drug, so it is considered to develop an oral solution that can meet the stability requirements , and can flexibly adjust the dosage of the solution

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