Method for synthesizing methoxyamine hydrochloride

Abstract

The invention relates to the technical field of compound synthesis methods, and discloses a method for synthesizing methoxyamine hydrochloride. The method comprises the following steps: adding water, sodium hydroxide, diacetylmonoxime and a phase transfer catalyst into a reaction kettle; after cooling, adding a methylation reagent; conducting standing for layering to obtain an organic layer, a water layer and a distilled water layer, collecting distillate, combining an oil layer and the distillate, and adding hydrochloric acid for mixing to obtain a mixed solution; feeding and rectifying the mixed solution from the middle of a rectifying column, recovering butanone and methanol at the top of the column, recovering a methoxyamine hydrochloride solution at the bottom of the column, and carrying out evaporating and dehydrating to obtain a concentrated solution; and cleaning a reaction kettle, wherein a stirring mechanism and a cleaning mechanism are arranged in the reaction kettle, the cleaning mechanism comprises a scraping plate, a spraying pipe, a lifting assembly and a rotating assembly, a water inlet pipe and a cleaning nozzle are connected to the spraying pipe, the reaction kettle comprises a kettle body and a kettle cover, the water outlet end of the cleaning nozzle faces the side wall of the kettle body, and the scraping plate is attached to the side wall of the kettle body. The method has the effect of conveniently cleaning residues on the side wall of the kettle body.

Description

technical field [0001] The present application relates to the technical field of compound synthesis methods, in particular to a method for synthesizing methoxyamine hydrochloride. Background technique [0002] Methoxyamine hydrochloride is an important chemical product and pharmaceutical intermediate, widely used in color photography and film printing, as a reducing agent in the organic synthesis industry to prepare oximes, and in the production of sulfamethoxazole, ethinoxazole, and hydroxyurea in medicine. , Cefuroxime, etc. [0003] As an important equipment in the chemical synthesis process, the reaction kettle is one of the necessary equipment in the synthesis process of methoxyamine hydrochloride, and its cleanliness directly affects the quality of the product. The traditional reaction kettle generally includes a kettle body and a kettle cover. After the reactants are mixed and reacted in the kettle body, some of them will inevitably remain on the side wall of the ket...

AI Technical Summary

Problems solved by technology

The traditional reaction kettle generally includes a kettle body and a kettle cover. After the reactants are mixed and reacted in the kettle body, some of them will inevitably remain on the side wall of the kettle body, and the residues on the side wall of the kettle body are generally removed by regular cleaning. , the kettle cover needs to be removed from the kettle body when cleaning, the operation is cumbersome and needs to be improved

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