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Production process for simultaneously producing ginkgolide, ginkgo flavone, ginkgo polysaccharide and shikimic acid

A production process, the technology of ginkgo flavonoids, applied in the production process of ginkgo polysaccharides and shikimic acid, ginkgo flavonoids, and ginkgolides at the same time, can solve the problems of increasing the production process, high cost of raw materials, large amount of organic solvents, etc., to achieve The effect of reducing the evaporation of acetic acid, improving product quality and reducing production energy consumption

Active Publication Date: 2021-12-17
南京久安源环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mainly have the following defects: (1) The amount of organic solvent is large, the cost of raw materials is high, and the organic solvent is unsafe. All electrical equipment in the extraction workshop must adopt explosion-proof grades, which greatly increases the cost; (2) Use petroleum ether extraction or deacidification resin to remove ginkgo biloba acid, increase the production process, high production cost, and introduce impurities; (3) many steps, long route, low product purity and low yield; (4) serious pollution and severe environmental problems
(5) It is not suitable for large-scale production, and the unit output cost is high
This method mainly has the following defects: (1) the carbon dioxide supercritical extraction device is expensive; (2) the energy consumption is high, and the production cost is high; (3) the congenital defect of the process makes it impossible to carry out large-scale production

Method used

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  • Production process for simultaneously producing ginkgolide, ginkgo flavone, ginkgo polysaccharide and shikimic acid
  • Production process for simultaneously producing ginkgolide, ginkgo flavone, ginkgo polysaccharide and shikimic acid
  • Production process for simultaneously producing ginkgolide, ginkgo flavone, ginkgo polysaccharide and shikimic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Embodiment 1: according to such as figure 1 The flowchart shown for the extraction of Ginkgo polysaccharides and shikimic acid:

[0111] (1) Ginkgo biloba is crushed to 20 meshes, leached with 60% ethanol solution at 50-80° C., and extracted 6 times to obtain the crude extract of ginkgo biloba;

[0112] (2) The crude extract obtained in step (1) is evaporated and concentrated, and after being concentrated 6 times, the Ginkgo biloba extract concentrate is obtained, and ethanol is recovered simultaneously;

[0113] (3) centrifuging the ginkgo leaf extract concentrate obtained in step (2) at 6000rpm / min disc centrifuge for 10min to obtain the ginkgo extract centrate;

[0114] (4) After the ginkgo extract centrifugate obtained in step (3) is filtered and clarified through the ceramic ultrafiltration membrane after activation modification, and impurities are removed, the ceramic membrane filtrate is obtained, wherein the content of ginkgo polysaccharide is 0.47%, and the co...

Embodiment 2

[0128] Embodiment 2: according to as figure 1 The flowchart shown for the extraction of Ginkgo polysaccharides and shikimic acid:

[0129] (1) Ginkgo biloba is crushed to 20 meshes, leached with 60% ethanol solution at 50-80° C., and extracted 6 times to obtain the crude extract of ginkgo biloba;

[0130] (2) The crude extract obtained in step (1) is evaporated and concentrated, and after being concentrated 6 times, the Ginkgo biloba extract concentrate is obtained, and ethanol is recovered simultaneously;

[0131] (3) centrifuging the ginkgo leaf extract concentrate obtained in step (2) at 6000rpm / min disc centrifuge for 10min to obtain the ginkgo extract centrate;

[0132] (4) After the ginkgo extract centrifugate obtained in step (3) is filtered and clarified through the ceramic ultrafiltration membrane after activation and modification, and impurities are removed, the ceramic membrane filtrate is obtained, wherein the content of ginkgo polysaccharide is 0.48%, and the conte...

Embodiment 3

[0146] Embodiment 3: according to such as figure 1 The flowchart shown for the extraction of Ginkgo polysaccharides and shikimic acid:

[0147] (1) Ginkgo biloba is crushed to 20 meshes, leached with 60% ethanol solution at 50-80° C., and extracted 6 times to obtain the crude extract of ginkgo biloba;

[0148] (2) The crude extract obtained in step (1) is evaporated and concentrated, and after being concentrated 6 times, the Ginkgo biloba extract concentrate is obtained, and ethanol is recovered simultaneously;

[0149] (3) centrifuging the ginkgo leaf extract concentrate obtained in step (2) at 6000rpm / min disc centrifuge for 10min to obtain the ginkgo extract centrate;

[0150] (4) after the ginkgo extract centrifugate obtained by step (3) is filtered and clarified through the ceramic ultrafiltration membrane after the activation modification, after impurity removal, obtain such as figure 2 The shown ceramic membrane filtrate, wherein, the content of ginkgo polysaccharide...

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Abstract

The invention discloses a production process for simultaneously producing ginkgolide, ginkgo flavone, ginkgo polysaccharide and shikimic acid, wherein the production process comprises the following steps: (1) filtering a ginkgo extracting solution through a ceramic membrane activated by organic acid to obtain a ceramic membrane filtrate, and extracting to obtain an organic phase and a water phase, wherein the organic phase is liquid containing ginkgolide; (2) adsorbing the obtained water phase by resin to obtain effluent; and desorbing to obtain a desorption liquid, wherein the desorption liquid is liquid containing ginkgo flavone; and (3) filtering and concentrating the obtained effluent through an ultrafiltration membrane to obtain trapped fluid and permeated fluid, wherein the trapped fluid is liquid containing ginkgo polysaccharide, and the permeated fluid is liquid containing shikimic acid. The adopted ceramic membrane not only can resist high temperature, high pressure and chemical corrosion and is long in service life, but also can effectively filter and remove suspended solids, colloids and macromolecular vegetable proteins, improve the product quality, reduce the turbidity and improve the yield.

Description

technical field [0001] The invention belongs to the field of natural medicine extraction, and in particular relates to a production process for simultaneously producing ginkgolides, ginkgo flavonoids, ginkgo polysaccharides and shikimic acid. Background technique [0002] Ginkgo biloba is the dry leaf of Ginkgo biloba L. Harvest in autumn when leaves are still green and dry in time. It is generally artificially cultivated, and the cultivation area reaches Liaoning in the north, Guangdong in the south, Zhejiang in the east, Shaanxi and Gansu in the west, and Sichuan, Guizhou, and Yunnan in the southwest. It has the effects of promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, astringing the lungs and relieving asthma, reducing turbidity and reducing fat. For blood stasis blocking collaterals, chest obstruction and heartache, apoplexy hemiplegia, lung deficiency cough and asthma, hyperlipidemia. Ginko Biloba Extract (GBE) is a ty...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/22C07C51/42C07C51/48C07C51/47C07C62/32C07D311/30C07D311/40C08B37/00
CPCC07D493/22C07C51/42C07C51/48C07C51/47C07D311/30C07D311/40C08B37/0003C07C2601/16C07C62/32
Inventor 凌国庆陈磊刘怀红储斌张南南李国学方威
Owner 南京久安源环保科技有限公司
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