Liquid oil-in-water composition

A technology for liquid water and composition, applied in the field of liquid oil-in-water composition, can solve the problems of lack of viscosity stability, viscosity over time, instability, etc., achieve excellent emulsion stability, maintain effect, and improve stability Effect

Pending Publication Date: 2021-12-17
KOBAYASHI KOSE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, since α-gel is an intermediate phase between lamellar liquid crystals and coagulants, it is generally unstable, and the oil-in-water emulsion compositions containing α-gel obtained by the techniques of the above-mentioned Patent Documents 1 and 2 also have a viscosity change over time. In the case of lack of viscosit

Method used

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  • Liquid oil-in-water composition
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  • Liquid oil-in-water composition

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0118] Reference Example 1: Modulation of lotion containing liposomes

[0119] The composition of the composition shown below is modulated by the following preparation method. For the resulting lotion, electron microscope observation was performed. Put the electronic microscope photo Figure 4 middle.

[0120] Reference Example 1: Makeup Water

[0121] (Element) (%)

[0122] Phospholipid 1.0

[0123] 2. Yellow original glue 0.1

[0124] 3. Carboxyvinyl polymer 0.05

[0125]4 1,3-butanediol 20.0

[0126] 5. Glycerol 4.5

[0127] 6. Sodium hydroxide 0.02

[0128] 7. paraben 0.1

[0129] 8. Perfume trace

[0130] 9. Purified water Balance.

[0131] (Preparation)

[0132] A: Process number 8 and 9 of the body portion of the liposome

[0133] B: The remaining ingredients were mixed all

[0134] C: mixing A and B, to give a lotion.

[0135] image 3 Α emulsion having a gel film structure of the present invention, an oil droplet phase inside, whereas Figure 4 Liposomes having no internal ...

Example

[0137] Examples 1 to 14 and Comparative Examples 1 to 12

[0138] Lotion composition shown in Table 3-6 below was prepared by the following preparation method. For the obtained lotion, according to the following measurement methods and evaluation criteria determined immediately after preparation and 50 deg.] C storage viscosity emulsion state after one month. Further, the structure for the presence of α-gel film coated emulsion droplets were evaluated by the following method. The results are also shown in Tables 3 to 6. It should be noted that the numeric values ​​in Table 3 refers to 6%.

[0139] [table 3]

[0140]

[0141] * 1 Nikkol SMT (Nikko Chemicals Co., Ltd.) was

[0142] * 2 Amisoft HA-P (Hong-Industrial Co., Ltd.)

[0143] * 3 Nikkol DDP-8 (Nikko Chemicals Co., Ltd.) was used.

[0144] [Table 4]

[0145]

[0146] [table 5]

[0147]

[0148] Table 6]

[0149]

[0150]

Example Embodiment

[0151] (Example 1,7,8,10)

[0152] A: A Nos. 1 to 15 were mixed and dissolved uniformly heated

[0153] B: The numbers 16 to 19 were mixed and dissolved uniformly heated

[0154] C: B was added to A and emulsified mixed

[0155] D: C is cooled using a microfluidizer twice, a high-pressure dispersion treatment (pressure 200MPa), to give a lotion.

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Abstract

The present invention addresses the problem of providing an oil-in-water emulsified composition that is liquid, but has excellent temporal viscosity stability and emulsification stability. The liquid oil-in-water composition according to the present invention as a solution to the problem is characterized by containing components (A)-(C): (A) a straight-chain saturated higher alcohol having 16 or more carbon atoms; (B) at least one anionic surfactant selected from the group consisting of sodium N-stearoyl-N-methyl taurate, and N-stearoyl-L-glutamic acid and salts thereof; and (C) a liquid oil, wherein the molar content ratio (A/B) of the component (A) to the component (B) is 2.8-6, the mass content ratio ((A+B)/C) of the total of the components (A) and (B) to the component (C) is 0.3-0.75, and the average emulsified particle size thereof is 160 nm or less.

Description

technical field [0001] The present invention relates to a liquid oil-in-water composition, and more specifically, to a liquid oil-in-water composition that is excellent in viscosity stability and emulsification stability over time despite being liquid. Background technique [0002] Conventionally, in an oil-in-water composition, when the content of the oil agent is increased, there has been a problem that separation and emulsion stability decrease such as separation and creaming occur over time. On the other hand, it has been attempted to blend a hydrophilic anionic surfactant and a higher aliphatic alcohol at a predetermined molar ratio to form an α-gel with a gel transition temperature of 60° C. or higher (Patent Document 1), or to prepare Mixing a mixture of higher alcohol and anionic surfactant in a specified molar ratio, and mixing a mixture of a water-soluble solvent with a specific IOB value and water in a specified mass ratio to form a bicontinuous microemulsion phas...

Claims

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Application Information

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IPC IPC(8): A61K8/44A61K8/06A61K8/31A61K8/34A61K8/46A61K8/891A61Q19/00
CPCA61Q19/00A61K8/31A61K8/44A61K8/34A61K8/46A61K8/06A61K8/891A61K8/062A61K8/342
Inventor 阿部茜H·早濑
Owner KOBAYASHI KOSE CO LTD
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