Docetaxel-containing preparation and application thereof
A technology of docetaxel and usage, applied in the field of chemical medicine, to achieve the effects of increasing drug concentration, high yield of finished products, and improving drug efficacy
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0040] 1) dissolving the succinylated gelatin peptide in a disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution with a pH value of 6.5, and preparing a solution with a concentration of 4wt% for use;
[0041] 2) Accurately weigh 500 mg of docetaxel, dissolve in 5 ml of methanol, and shake well;
[0042] 3) slowly drop the docetaxel solution in step 2) into the succinylated gelatin peptide solution described in step 1), mix,
[0043] 4) Set the power of the ultrasonic pulverizer to 400W for emulsification. The specific steps are: first perform shear emulsification, the shear speed of the high-speed shear is 25000rmp; the emulsification time is 20min; The frequency of emulsification is 50 Hz; the time of grinding and emulsification is 30 minutes, and the homogenization is carried out by a high-pressure homogenizer, the pressure is 800 Pa, and the homogenization is 45 minutes.
[0044] 5) After freeze-drying at -45°C for 24 hours, the nanoparticles of docetaxel...
Embodiment 2
[0047] 1) dissolving the succinylated gelatin peptide in a disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution with a pH value of 7.0, and preparing a solution with a concentration of 3.5 wt% for use;
[0048] 2) Accurately weigh 500 mg of docetaxel, dissolve in 5 ml of methanol, and shake well;
[0049] 3) slowly drop the docetaxel solution in step 2) into the succinylated gelatin peptide solution described in step 1), mix,
[0050] 4) Set the power of the ultrasonic pulverizer to 450W for emulsification. The specific steps are: first perform shear emulsification, the shear speed of the high-speed shear is 28000rmp; the emulsification time is 10min; The frequency of emulsification is 50 Hz; the time of grinding and emulsification is 20 minutes, and the homogenization is carried out by a high-pressure homogenizer, the pressure is 1000 Pa, and the homogenization is 45 minutes.
[0051] 5) After freeze-drying at -45°C for 24 hours, the nanoparticles of docet...
Embodiment 3
[0054] 1) dissolving the succinylated gelatin peptide in a disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution with a pH value of 7.2, and preparing a solution with a concentration of 4wt% for use;
[0055] 2) Accurately weigh 500 mg of docetaxel, dissolve in 5 ml of methanol, and shake well;
[0056] 3) slowly drop the docetaxel solution in step 2) into the succinylated gelatin peptide solution described in step 1), mix,
[0057] 4) Set the power of the ultrasonic pulverizer to 600W for emulsification. The specific steps are: first perform shear emulsification, and the shear speed of the high-speed shear is 22000rmp; the emulsification time is 20min; The frequency of emulsification is 40 Hz; the time of grinding and emulsification is 40 minutes, and the homogenization is carried out by a high-pressure homogenizer, the pressure is 800 Pa, and the homogenization is 60 minutes.
[0058] 5) After freeze-drying at -45°C for 24 hours, the nanoparticles of docet...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle size | aaaaa | aaaaa |
| particle size | aaaaa | aaaaa |
| particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More