Supercharge Your Innovation With Domain-Expert AI Agents!

Efficient minoxidil hair growth tincture containing purine nucleoside and preparation method of high-efficiency minoxidil hair growth tincture

A high-efficiency purine nucleoside technology, applied in the field of preparation of high-efficiency minoxidil hair growth tincture, can solve the problems of insufficient thickening effect, fast drug volatilization, long treatment cycle, etc.

Pending Publication Date: 2021-12-24
福州博德新材料科技有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sufficient clinical trials have confirmed that minoxidil has a good effect on androgenetic alopecia and alopecia areata, but long-term medication is required to maintain the effect, and although the overall hair density will increase after one year of treatment, there are still many The hair is relatively soft, the effect of thickening and thickening is insufficient, the treatment cycle is long, the efficiency is low, and the drug permeability is poor, the utilization rate is low, and the drug volatilizes quickly
[0003] The main problems of existing minoxidil tincture products are that long-term medication is required, the treatment cycle is long, the efficiency is low, and the drug permeability is insufficient, the utilization rate is low, a large number of patients are prone to dermatitis, and the treatment is easy to reach the bottleneck, which is generally easy to increase Hair density, but the effect on hair thickening and thickening is poor, and the effect is not good when used alone. It needs to be combined with oral finasteride to achieve better results. Finasteride is a 4-azasteroid Compound, it is a specific inhibitor of the intracellular enzyme-II type 5a-reductase in the process of testosterone metabolism into stronger dihydrotestosterone. Oral administration of finasteride in some patients will have side effects on other androgen-dependent tissues, Issues such as ejaculation disturbances, decreased libido, depressed mood, and breast development

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Efficient minoxidil hair growth tincture containing purine nucleoside and preparation method of high-efficiency minoxidil hair growth tincture
  • Efficient minoxidil hair growth tincture containing purine nucleoside and preparation method of high-efficiency minoxidil hair growth tincture
  • Efficient minoxidil hair growth tincture containing purine nucleoside and preparation method of high-efficiency minoxidil hair growth tincture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh 9 grams of adenosine with an electronic balance. Mix 200ml of sterile distilled water with adenosine, and stir it by magnetic force for 15 minutes under the condition of sealing in a water bath at 50°C, so that the adenosine is evenly dispersed and dissolved in sterile distilled water to obtain solution A.

[0039] Take minoxidil solid 70 grams with electronic balance. Slowly add the minoxidil solid to 300ml of ethanol solution with volume concentration of 75%, and quickly stir it by magnetic force for 20 minutes, let it fully dissolve, let it stand for 10 minutes, so that the insoluble minoxidil is fully precipitated, and the supernatant is poured Come out and record as solution B.

[0040] Weigh 10 grams of sildenafil solid with an electronic balance. Slowly add the sildenafil solid to solution B, and quickly stir it by magnetic force for 10 minutes to fully dissolve it, let it stand for 10 minutes to fully precipitate the insoluble sildenafil, pour out the su...

Embodiment 2

[0046] Take by weighing 25 grams of minoxidil solids with electronic balance. Mix 200ml of propylene glycol with minoxidil, stir for 20 minutes to disperse the minoxidil evenly in the propylene glycol, let stand for 15 minutes to fully precipitate the insoluble minoxidil, pour out the supernatant and record it as solution A.

[0047] Take by weighing 25 grams of sildenafil solid with electronic balance. Mix 200ml of propylene glycol with the sildenafil solid, stir for 20 minutes, let it fully dissolve, let it stand for 15 minutes to fully precipitate the insoluble sildenafil, pour out the supernatant and record it as solution B.

[0048] Weigh 8 grams of adenosine with an electronic balance. Slowly add solid adenosine to 200ml of sterile distilled water, and stir for 15 minutes in a water bath at 50°C with the seal sealed by magnetic stirring, so that the adenosine is uniformly dispersed and dissolved in sterile distilled water to obtain solution C.

[0049] The above three ...

Embodiment 3

[0052] Weigh 8g of adenosine, 2g of finasteride, 0.2g of retinoic acid, 0.01g of caffeine, 0.1g of fluocinolone acetate and 15g of azelaic acid with an electronic balance, first add adenosine to 100ml of sterile distilled water, Seal and magnetically stir in a water bath at 50°C for 15 minutes to obtain solution A; add azelaic acid, finasteride, fluocinolone acetate, caffeine and retinoic acid into 300ml of ethanol solution with a volume concentration of 75%, and seal and magnetically stir for 10 minutes , and then let it stand for 10 minutes to fully precipitate the insoluble solid to obtain supernatant solution B and precipitate 1.

[0053] Weigh 50g of minoxidil solid and 10g of sildenafil solid with an electronic balance, mix 500ml of propylene glycol with minoxidil and sildenafil solid, stir magnetically for 15 minutes, let it fully dissolve evenly, and let it stand for 10 minutes , to obtain supernatant solution C and precipitate 2.

[0054] Add solutions A and C slowly...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an efficient minoxidil hair growth tincture containing purine nucleoside and a preparation method of the minoxidil hair growth tincture. The purine nucleoside mainly refers to adenosine (adenosine). The efficient minoxidil hair growth tincture containing the purine nucleoside is prepared from the following raw materials: minoxidil, adenosine, sildenafil, finasteride, ethanol, propylene glycol, sterile distilled water, water-soluble azone, retinoic acid, fluocinonide, azelaic acid, caffeine and disodium ethylene diamine tetraacetate. The hair growth tincture is safe, efficient, short in hair growth period and good in action effect.

Description

technical field [0001] The invention relates to a hair growth tincture, in particular to a preparation method of a high-efficiency minoxidil hair growth tincture containing purine nucleosides for treating hair loss. Background technique [0002] Hair loss is a major problem faced by contemporary young people, and with the development of the times, the hair loss group continues to become younger. There are many reasons for hair loss. Common hair loss diseases mainly include androgenetic alopecia (seborrheic alopecia), hereditary alopecia, alopecia areata, etc. Both men and women can be affected. Minoxidil (Minoxidil, chemical name is 2,4-diamino-6-piperidinyl pyrimidine-3-oxide) is a kind of vasodilator, and is considered to be more effective topical chemical medicine for hair loss in the world at present. Minoxidil can grow hair through a variety of ways. The current research shows that minoxidil can directly stimulate the proliferation and differentiation of hair follicle ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7076A61K47/10A61K47/12A61K47/18A61K47/22A61P17/14A61K9/08A61K31/203A61K31/506A61K31/519A61K31/522A61K31/58A61K31/194
CPCA61K31/506A61K31/7076A61K31/519A61K31/58A61K31/522A61K31/203A61K31/194A61K47/183A61K47/22A61K47/10A61K9/08A61P17/14A61K2300/00
Inventor 黄鸿兴吴波张隆昆赵艳
Owner 福州博德新材料科技有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More