Efficient minoxidil hair growth tincture containing purine nucleoside and preparation method of high-efficiency minoxidil hair growth tincture
A high-efficiency purine nucleoside technology, applied in the field of preparation of high-efficiency minoxidil hair growth tincture, can solve the problems of insufficient thickening effect, fast drug volatilization, long treatment cycle, etc.
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Embodiment 1
[0038] Weigh 9 grams of adenosine with an electronic balance. Mix 200ml of sterile distilled water with adenosine, and stir it by magnetic force for 15 minutes under the condition of sealing in a water bath at 50°C, so that the adenosine is evenly dispersed and dissolved in sterile distilled water to obtain solution A.
[0039] Take minoxidil solid 70 grams with electronic balance. Slowly add the minoxidil solid to 300ml of ethanol solution with volume concentration of 75%, and quickly stir it by magnetic force for 20 minutes, let it fully dissolve, let it stand for 10 minutes, so that the insoluble minoxidil is fully precipitated, and the supernatant is poured Come out and record as solution B.
[0040] Weigh 10 grams of sildenafil solid with an electronic balance. Slowly add the sildenafil solid to solution B, and quickly stir it by magnetic force for 10 minutes to fully dissolve it, let it stand for 10 minutes to fully precipitate the insoluble sildenafil, pour out the su...
Embodiment 2
[0046] Take by weighing 25 grams of minoxidil solids with electronic balance. Mix 200ml of propylene glycol with minoxidil, stir for 20 minutes to disperse the minoxidil evenly in the propylene glycol, let stand for 15 minutes to fully precipitate the insoluble minoxidil, pour out the supernatant and record it as solution A.
[0047] Take by weighing 25 grams of sildenafil solid with electronic balance. Mix 200ml of propylene glycol with the sildenafil solid, stir for 20 minutes, let it fully dissolve, let it stand for 15 minutes to fully precipitate the insoluble sildenafil, pour out the supernatant and record it as solution B.
[0048] Weigh 8 grams of adenosine with an electronic balance. Slowly add solid adenosine to 200ml of sterile distilled water, and stir for 15 minutes in a water bath at 50°C with the seal sealed by magnetic stirring, so that the adenosine is uniformly dispersed and dissolved in sterile distilled water to obtain solution C.
[0049] The above three ...
Embodiment 3
[0052] Weigh 8g of adenosine, 2g of finasteride, 0.2g of retinoic acid, 0.01g of caffeine, 0.1g of fluocinolone acetate and 15g of azelaic acid with an electronic balance, first add adenosine to 100ml of sterile distilled water, Seal and magnetically stir in a water bath at 50°C for 15 minutes to obtain solution A; add azelaic acid, finasteride, fluocinolone acetate, caffeine and retinoic acid into 300ml of ethanol solution with a volume concentration of 75%, and seal and magnetically stir for 10 minutes , and then let it stand for 10 minutes to fully precipitate the insoluble solid to obtain supernatant solution B and precipitate 1.
[0053] Weigh 50g of minoxidil solid and 10g of sildenafil solid with an electronic balance, mix 500ml of propylene glycol with minoxidil and sildenafil solid, stir magnetically for 15 minutes, let it fully dissolve evenly, and let it stand for 10 minutes , to obtain supernatant solution C and precipitate 2.
[0054] Add solutions A and C slowly...
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