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Production method and application of fluorine-18 ions

A production method and ion technology, which is applied in the production field of fluorine-18 ions, can solve problems such as the inability to guarantee the stable use of fluorine-18 ion labeling agents, low radioactive activity of fluorine-18 ion solutions, and clinical application limitations, and achieve guarantee The effect of radioactive activity, improved convenience, and excellent developing effect

Inactive Publication Date: 2021-12-24
上海安迪科正电子技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the radioactive activity of the fluorine-18 ion solution prepared by the above preparation method is low, so the stable use of the fluorine-18 ion-labeled developer cannot be guaranteed, and it has basically lost its development function at the end of the half-life, which has brought clinical application. very restrictive

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  • Production method and application of fluorine-18 ions
  • Production method and application of fluorine-18 ions
  • Production method and application of fluorine-18 ions

Examples

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Effect test

preparation example 1

[0059] A kind of target water, its preparation steps are as follows:

[0060] (1) Purify 100 g of recovered waste liquid with an oxygen-18 abundance of 50%, and the purification process includes the following steps:

[0061] a. Removal of organic microorganisms: use glass wool core to filter, and the filtration accuracy is 5 μm;

[0062] b. Removal of organic matter: use ultraviolet light oxidation, the ultraviolet wavelength is 172nm, and the time is 25min;

[0063] c. Removal of inorganic substances: reverse osmosis membrane method is selected, wherein the surface micropore diameter of the reverse osmosis membrane is 1.0nm;

[0064] After the organic microorganisms, organic matter and inorganic matter in the recovered waste liquid are removed, the recovered heavy oxygen water can be produced;

[0065] (2) Then, at a temperature of 4°C, mix the heavy oxygen water with an abundance of 97% and the recovered heavy oxygen water at a ratio of 1:0.2 to obtain target water, and ke...

preparation example 2

[0067] A kind of target water, the difference from Preparation Example 1 is that its preparation steps are as follows:

[0068] (1) Purify 100 g of recovered waste liquid with an oxygen-18 abundance of 50%, and the purification process includes the following steps:

[0069] a. Removal of organic microorganisms: use glass wool core to filter, and the filtration accuracy is 3 μm;

[0070] b. Removal of organic matter: use ultraviolet light oxidation, the ultraviolet wavelength is 190nm, and the time is 30min;

[0071] c. Removal of inorganic substances: reverse osmosis membrane method is selected, wherein the surface micropore diameter of the reverse osmosis membrane is 0.5nm;

[0072] After the organic microorganisms, organic matter and inorganic matter in the recovered waste liquid are removed, the recovered heavy oxygen water can be produced;

[0073] (2) Then, at a temperature of 4°C, mix the heavy oxygen water with an abundance of 97% and the recovered heavy oxygen water ...

preparation example 3

[0075] A kind of target water, the difference from Preparation Example 1 is that its preparation steps are as follows:

[0076] (1) Purify 100 g of recovered waste liquid with an oxygen-18 abundance of 50%, and the purification process includes the following steps:

[0077] a. Removal of organic microorganisms: filter with glass wool core, and the filtration accuracy is 8 μm;

[0078] b. Removal of organic matter: use ultraviolet light oxidation, the ultraviolet wavelength is 160nm, and the time is 20min;

[0079] c. Removal of inorganic substances: reverse osmosis membrane method is selected, wherein the surface micropore diameter of the reverse osmosis membrane is 1.5nm;

[0080] After the organic microorganisms, organic matter and inorganic matter in the recovered waste liquid are removed, the recovered heavy oxygen water can be produced;

[0081] (2) Then, at a temperature of 4°C, mix the heavy oxygen water with an abundance of 97% and the recovered heavy oxygen water at...

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Abstract

The invention relates to the field of radiopharmaceuticals, in particular to a production method and application of fluorine-18 ions. The invention discloses a production method of fluorine-18 ions. The production method comprises the following steps of S1, checking equipment, S2, condition setting: selecting a required target material, and setting target shooting time and beam current, S3, waste gas treatment, S4, preparation of target water: firstly, carrying out purification treatment on the recovered waste liquid with the oxygen-18 abundance of 25-50% to prepare recovered heavy-oxygen water, mixing the heavy-oxygen water with the abundance of 97% with the recovered heavy-oxygen water in proportion under a low-temperature condition to prepare target water, S5, target water filling, and S6, starting target shooting. The fluorine-18 ions prepared in the invention have relatively high radioactive activity, and have a relatively strong developing effect after being applied to marking deoxyglucose, polypeptides, nanoparticles and bioactive molecules.

Description

technical field [0001] The application relates to the field of radiopharmaceuticals, more specifically, it relates to a production method and application of fluorine-18 ions. Background technique [0002] Positron emission tomography (PET) is a cutting-edge technology for biomedical research and clinical diagnosis in the 21st century. , biochemical changes, and insight into the activities of labeled drugs in normal people or patients. It has obvious advantages in the examination of tumor staging and typing, identification of benign and malignant tumors, and efficacy evaluation. Among them, the positronium fluorine-18 ion ( 18 F ion) as an example, has a lower positron energy (512keV) and a higher half-life (t1 / 2=109.8min). [0003] The production method of the fluorine-18 ion solution in the related art comprises the following steps: a, ionizing the ion source to make it emit particle beams; b, accelerating the particles; c, irradiating the target, and bombarding the heavy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00A61K51/04A61K51/08A61K101/02
CPCB01J19/0006A61K51/0491A61K51/08
Inventor 王历
Owner 上海安迪科正电子技术有限公司