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Synthesis method of bagasse xylan/naringin-g-HPMA acetylsalicylate

A technology of acetylsalicylate and synthesis method, applied in the directions of drug combination, anti-tumor drug, bulk chemical production, etc., to achieve the effects of broad development prospects, enhanced biological activity, and expanded application scope

Inactive Publication Date: 2021-12-31
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Acetylsalicylic acid is a preventive drug for cardiovascular and cerebrovascular diseases. It has antithrombotic and antiplatelet aggregation effects. With the wide application and in-depth research of acetylsalicylic acid, it has been found that it has preventive and therapeutic effects on certain cancers, especially It is colorectal cancer, but has a certain incidence of adverse reactions, especially for the digestive system

Method used

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  • Synthesis method of bagasse xylan/naringin-g-HPMA acetylsalicylate
  • Synthesis method of bagasse xylan/naringin-g-HPMA acetylsalicylate
  • Synthesis method of bagasse xylan/naringin-g-HPMA acetylsalicylate

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Experimental program
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Embodiment

[0040] (1) Weigh 4.5 g of bagasse xylan and place it in a vacuum constant temperature drying oven at 60° C. for 24 hours to a constant weight to obtain a dry basis of bagasse xylan.

[0041](2) Weigh 0.3 g of naringin and place it in a vacuum constant temperature drying oven at 60°C for 24 hours to a constant weight to obtain dry base naringin.

[0042] (3) Weigh 0.30g of ammonium persulfate into a 50mL beaker, add 15mL of distilled water, stir at room temperature for 10 minutes to dissolve, make an initiator solution, pour it into a 100mL constant pressure dropping funnel, and set aside.

[0043] (4) Measure 3.6mL of analytically pure hydroxyethyl methacrylate into a 50mL beaker, add 15mL of distilled water and 0.1mL of chemically pure Tween-80, stir and dissolve at room temperature to obtain a monomer emulsion, pour into another 100mL constant In the pressure dropping funnel, set aside.

[0044] (5) Weigh 4.5g of dry base bagasse xylan obtained in step (1) and 0.3g of dry b...

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Abstract

The invention discloses a synthesis method of bagasse xylan / naringin-g-HPMA acetylsalicylate. The preparation method comprises the following steps: by taking bagasse xylan (BX) and naringin (Nar) as main raw materials, hydroxypropyl methacrylate (HPMA) as a grafting monomer and ammonium persulfate as an initiator, synthesizing bagasse xylan / naringin-g-HPMA through free radical reaction in a water solvent; and by taking ionic liquid 1-butyl-2, 3-dimethylimidazolium as a solvent and acetylsalicylic acid as an esterifying agent, carrying out catalytic esterification reaction to synthesize the final product bagasse xylan / naringin-g-HPMA acetylsalicylate. The obtained product can effectively inhibit in-vitro proliferation of colorectal cancer cells and induce apoptosis of the colorectal cancer cells, lays a foundation for research of novel colorectal cancer prevention drugs, and has wide development prospects in the fields of biomass materials, medicines and the like.

Description

technical field [0001] The invention relates to the technical field of biomass materials and fine chemicals, in particular to a method for synthesizing bagasse xylan / naringin-g-HPMA acetylsalicylate with biological activity. Background technique [0002] The rapid development of modern industry has promoted the prosperity of human material civilization to a certain extent, but it has also caused a lot of waste of biomass resources. Naringin is a natural flavor improver, which can not only be used in the production and prevention of cardiovascular and cerebrovascular diseases, but also play an anticancer role by inhibiting the activity of cytochromes involved in carcinogenic activation. However, naringin is generally treated as garbage, which not only causes a great waste of resources, but also pollutes the environment. In recent years, there have been reports on the biological activity of naringin, but they mainly focus on antibacterial and antioxidative aspects, and there ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/20C08F222/38C08F8/14C08F2/44C08K5/1545A61P35/00
CPCC08F251/00C08F8/14C08F2/44C08K5/1545A61P35/00C08F220/20C08F222/385Y02P20/54
Inventor 李和平苏越田可欣赵斌张淑芬吕奕菊邹志明刘红丽谢超煜
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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