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Active element doped mineralized collagen nanofiber and preparation method thereof

A technology of active elements and mineralized collagen, which is applied in the field of biomedical materials, can solve the problems of complex and cumbersome methods and limit the development and application of artificial synthetic materials, and achieve the effect of bone regeneration

Pending Publication Date: 2022-01-11
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the methods for synthesizing mineralized collagen doped with trace elements in the prior art are complex and cumbersome, and the obtained mineralized collagen is not in the form of fibers, which greatly limits the development and application of such artificial synthetic materials.

Method used

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  • Active element doped mineralized collagen nanofiber and preparation method thereof
  • Active element doped mineralized collagen nanofiber and preparation method thereof
  • Active element doped mineralized collagen nanofiber and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Dissolve the type I collagen sponge in ultrapure phosphoric acid aqueous solution, wherein the concentration of the phosphoric acid solution is 0.5mol / L, and the volume ratio of the mass of the type I collagen sponge to the phosphoric acid solution is 0.1g:1L. The obtained mixture was thoroughly mixed by stirring with a magnetic stirrer, and the mixing time was 6 hours, so that the added type I collagen template was fully dissolved, and recorded as an anion solution for future use. During the stirring process, the temperature of the system was maintained between 35-38°C.

[0057] (2) Prepare calcium chloride ultrapure aqueous solution, and add CaCl according to the preset doping cation salt (Sr) molar relative percentage of 9%. 2 Stir in the solution and dissolve evenly (that is, the molar ratio of strontium ions to calcium ions is 9:91).

[0058] Configure NaOH ultrapure aqueous solution to ensure that the molar ratio of (calcium ion + strontium ion) / OH is 2. Add...

Embodiment 2

[0069] (1) Dissolve the type I collagen sponge in ultrapure phosphoric acid aqueous solution, wherein the concentration of the phosphoric acid solution is 2mol / L, and the volume ratio of the quality of the type I collagen sponge to the phosphoric acid solution is 10g:1L. The obtained mixture was fully mixed by stirring with a magnetic stirrer, and the mixing time was 12 hours, so that the added type I collagen template was fully dissolved, and recorded as an anion solution for future use. During the stirring process, the temperature of the system was maintained between 35°C and 38°C.

[0070] (2) Prepare calcium chloride ultrapure aqueous solution, and add CaCl according to the preset doping cation salt (Sr) molar relative percentage of 7%. 2 Stir in the solution and dissolve evenly (that is, the molar ratio of strontium ions to calcium ions is 7:93).

[0071] Configure NaOH ultrapure aqueous solution to ensure that the molar ratio of (calcium ion + strontium ion) / OH is 2. A...

Embodiment 3

[0081] (1) Dissolve the type I collagen sponge in ultrapure phosphoric acid aqueous solution, wherein the concentration of the phosphoric acid solution is 1mol / L, and the volume ratio of the quality of the type I collagen sponge to the phosphoric acid solution is 2g:1L. The obtained mixture was thoroughly mixed by stirring with a magnetic stirrer, and the mixing time was 9 hours, so that the added type I collagen template was fully dissolved, and recorded as an anion solution for future use. During the stirring process, the temperature of the system was maintained between 35°C and 38°C.

[0082] (2) Prepare calcium chloride ultrapure aqueous solution, and add CaCl according to the preset doping cation salt (Sr) molar relative percentage of 7%. 2 Stir in the solution and dissolve evenly (that is, the molar ratio of strontium ions to calcium ions is 7:93).

[0083] Configure NaOH ultrapure aqueous solution to ensure that the molar ratio of (calcium ion + strontium ion) / OH is 2....

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Abstract

The invention provides active element doped mineralized collagen nanofiber and a preparation method thereof. The mineralized collagen nanofiber is composed of collagen fiber and needle-like hydroxyapatite crystals; and part of calcium elements in crystal lattices of the hydroxyapatite crystals are substituted by positive ions containing active elements, and / or, part of phosphate radicals in the crystal lattices of the hydroxyapatite crystals are substituted by negative ions containing active elements. The preparation process is simple and easy to implement, and a product obtained by compounding the obtained mineralized collagen nanofiber and a high polymer material (collagen, PCL and the like) can obviously improve the strength and rigidity of an original high polymer material. In addition, a plurality of active element doping schemes are adopted to meet the requirement of a tumor inhibition, anti-infection and immunoregulation cell microenvironment provided by material degradation in a bone repair process. A good thought is provided for design and development of the high-molecular bone repair material, and greater economic benefits are brought to human health and social development.

Description

technical field [0001] This article relates to but not limited to the field of biomedical materials, especially relates to but not limited to a mineralized collagen nanofiber doped with active elements and a preparation method thereof. Background technique [0002] Natural bone is mainly composed of inorganic components and organic components. The inorganic components are mainly low-crystalline hydroxyapatite (hydroxyapatite, HA), while the organic components are mainly composed of proteins and polysaccharides. Compared with natural bone materials, biomimetic materials prepared in vitro have the advantages of sufficient sources and low immunogenicity. There are many bone materials that choose calcium and phosphorus as the main components to simulate natural bone components, and even use in vitro mineralization methods to simulate the smallest structural unit of natural bone, which can have a good osteogenic induction effect. [0003] However, in terms of clinical needs, the...

Claims

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Application Information

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IPC IPC(8): D01F4/00D01F1/10
CPCD01F4/00D01F1/10
Inventor 赵勇刚王秀梅郑靖川熊洋
Owner TSINGHUA UNIV
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