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Application of a traditional Chinese medicine composition in the preparation of drugs for preventing and treating gastrointestinal tumors

A technology of tumor drugs and compositions, applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve the problem that the preventive effect of small intestine tumors and colorectal cancer prevention has not been reported, and achieve the prevention of small intestine tumors and colorectal tumors Occurrence, high safety, good curative effect

Active Publication Date: 2022-08-09
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Qingchang Wenzhong Tablet is a prescription of Yangzijiang Pharmaceutical Co., Ltd., which consists of Coptidis Rhizome, Paojiang, Qingdai, Sophora flavescens, Panax notoginseng, simmering wood fragrance, Burnet charcoal, and roasted licorice according to 7-11 parts, 7-11 parts, 4- 1 part, 7-11 parts, 4-8 parts, 4-8 parts, 7-11 parts, 1-5 parts by weight, has significant clinical curative effect in mild to moderate UC patients, can Significantly improve the symptoms of active UC in patients with diarrhea accompanied by mucus, pus and blood, reduce inflammation, and repair mucosal lesions, but its preventive effect on small intestinal tumors and colorectal cancer has not been reported

Method used

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  • Application of a traditional Chinese medicine composition in the preparation of drugs for preventing and treating gastrointestinal tumors
  • Application of a traditional Chinese medicine composition in the preparation of drugs for preventing and treating gastrointestinal tumors
  • Application of a traditional Chinese medicine composition in the preparation of drugs for preventing and treating gastrointestinal tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 A kind of preparation method of Qingchang Wenzhong tablet dry paste powder

[0038] Recipe: The parts by weight of each component are 10 parts of Coptis chinensis, 7 parts of Paojiang, 5 parts of Indigo Naturalis, 10 parts of Sophora flavescens, 6 parts of Panax notoginseng, 4 parts of simmered wood incense, 10 parts of Burnet charcoal, and 3 parts of Zhigancao.

[0039]Take Coptis chinensis, Panax notoginseng, and Indigo Naturalis according to the formula, add 10 times the amount of 60v% ethanol for reflux extraction, extract twice, 2 hours each time, combine the extracts, filter the extracts, centrifuge (centrifugation speed 6000r / min, time 10min) ), concentration (60 ℃) to relative density is 1.30, drying (50 ℃), get dry paste powder I; , extract 2 times, 2h each time, combine the extracts, filter and concentrate the extracts (60°C) to a relative density of 1.10, add ethanol to the alcohol concentration of 60v%, stand (temperature 8°C, time 12h) filter, ...

Embodiment 2

[0041] Recipe: The parts by weight of each component are 12 parts of Coptis chinensis, 2 parts of Paojiang, 3 parts of Indigo Naturalis, 12 parts of Sophora flavescens, 5 parts of Panax notoginseng, 5 parts of simmering wood incense, 6 parts of Burnet charcoal, and 4 parts of Zhigancao.

[0042] Take Coptis chinensis, Panax notoginseng and Indigo Naturalis according to the formula, add 10 times the amount of 60v% ethanol for reflux extraction twice, 2h each time, combine the extracts, filter, centrifuge at 6000r / min for 10min, and concentrate the centrifuged liquid to 60% under reduced pressure. Extract the extract with a relative density of 1.30 at ℃, and then dry it at 50 ℃ to obtain dry extract powder I; take Sophora flavescens, simmered wood incense, Diyu charcoal, Paojiang, licorice, add 10 times the amount of water to reflux and extract twice, Each 2h, the extracts were combined, filtered, concentrated at 60°C to obtain a medicinal solution with a relative density of 1.10...

Embodiment 3

[0044] 1. Test method

[0045] (1) Drug configuration: ①AOM solution: Dissolve AOM in sterile distilled water to prepare a 10mg / mL stock solution, and store at -20°C. On the day of use, dilute the stock solution 10 times with sterile normal saline to obtain a working solution of 1 mg / mL (Note: the stock solution should avoid repeated freezing and thawing; the dose for intraperitoneal injection is 10 mg / kg, that is, 0.1 mL is injected per 10 g of mice AOM working solution). ②DSS solution: Weigh 20g of DSS powder, dissolve it in 1L of sterile distilled water, and prepare a 2% DSS solution. ③ Qingchang Wenzhong solution: Weigh an appropriate amount of Qingchang Wenzhong dry paste powder prepared in Example 1 and dissolve it in water to prepare solutions of 0.175g / ml and 0.0875g / ml; wherein, 0.0175g and 0.0875g refer to It is the weight of Qingchang Wenzhong tablet dry paste powder.

[0046] (2) Model establishment: ①APC min / + Mouse model: fed with high-fat diet, spontaneously...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and treating gastrointestinal tumors. The active ingredients of the traditional Chinese medicine composition include the following components, and the formula includes the following components: Coptis chinensis, Paojiang, Indigo Naturalis , Sophora flavescens, Panax notoginseng, simmering woody incense, Burnet charcoal, Zhigancao. The invention utilizes Qingchang Wenzhong Tablet to develop a new class of traditional Chinese medicines with good curative effect and high safety for preventing small intestinal tumors and colorectal cancer, which can prevent the occurrence of small intestinal tumors and colorectal tumors. This not only provides a new indication for the application of Qingchang Wenzhong Tablet, but also provides a new therapeutic drug and therapeutic approach for the prevention of small intestinal tumors and the prevention and treatment of colorectal cancer.

Description

technical field [0001] The invention belongs to the field of anti-tumor drugs, in particular to the application of a traditional Chinese medicine composition in the preparation of a drug for preventing and treating gastrointestinal tumors. Background technique [0002] Gastrointestinal tumors mainly include esophageal tumors, stomach tumors, small intestinal tumors, colorectal tumors, etc. Colorectal tumors are a type of colorectal tumors. Bleeding secondary to gastrointestinal tumors is relatively common, and upper gastrointestinal tumors are one of the common causes of upper gastrointestinal bleeding, accounting for about 2%-3% of all upper gastrointestinal bleeding causes. Among benign tumors, esophageal, gastric and duodenal polyps or polyposis are the most common. In addition, leiomyomas, adenomas or neurofibromas can also cause upper gastrointestinal bleeding. Malignant tumors mainly include esophageal cancer, gastric cancer, colorectal cancer and so on. When bleedin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P35/00A61K33/44
CPCA61K36/718A61K36/9068A61K36/704A61K36/315A61K36/195A61K36/489A61K36/258A61K36/285A61K36/739A61K33/44A61K36/484A61P35/00A61K2300/00
Inventor 杨洋叶娟曹鹏任凌丽赵冰谭琴陈钟陈炜伟陈艺芳
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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