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Method for improving dry granulation formability of traditional Chinese medicine formula granules through powder wetting

A technology of traditional Chinese medicine formula granules and dry granulation, which is applied in the direction of medical formulas, devices that make medicines into special physical or ingestible forms, and medical preparations with non-active ingredients, etc. Residues, affect the smell inspection of licorice formula granules, and cannot guarantee that the dry paste powder has no alcohol smell, etc., to improve the dry granulation formability of the dry paste powder, avoid alcohol odor residue, and eliminate potential safety hazards

Active Publication Date: 2022-01-21
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is time-consuming and labor-intensive, and it cannot guarantee that there is no alcohol residue in the dry cream powder, and it cannot guarantee that the dry cream powder has no alcohol smell, and it may also affect the smell inspection of licorice formula granules.

Method used

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  • Method for improving dry granulation formability of traditional Chinese medicine formula granules through powder wetting
  • Method for improving dry granulation formability of traditional Chinese medicine formula granules through powder wetting

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Cuscuta formula granule dry paste powder 100kg, water content 2.1%, dry granulation formability is very low, dry paste powder standard tablet hardness 17N. Weigh 5 kg of ethyl cellulose with a water content of 2.5%. According to the calculation of 5.0% water content of the dry cream powder after mixing, spray 3.18 kg of purified water into the ethyl cellulose, stir and mix evenly, and form a powder wet state. Then the wetted ethyl cellulose was added to the dry paste powder of Cuscuta seed, stirred and mixed evenly, the formability of dry granulation was obviously improved, and the standard tablet hardness of dry paste powder increased to 120N. When only ethyl cellulose is added without adding water, the standard tablet hardness of dry paste powder can only be increased to 23N, which cannot meet the formability requirements of dry granulation. It shows that increasing the water content of dry cream powder by powder wetting is the decisive factor to improve the dry gran...

Embodiment 2

[0025] Deer horn glue formula granule dry paste powder 100kg, water content 1.9%, dry granulation formability is very low, dry paste powder standard tablet hardness 23N. Weigh 5 kg of magnesium aluminum silicate with a water content of 2.5%. Calculated according to the water content of 5.0% in the dry paste powder after mixing, spray 3.39 kg of purified water into the magnesium aluminum silicate, stir and mix evenly, and form a powder wet state. Then, the wetted magnesium aluminum silicate was added to the dry paste powder of deer horn gum, stirred and mixed evenly, the formability of dry granulation was obviously improved, and the standard tablet hardness of the dry paste powder increased to 142N. When only magnesium aluminum silicate is added without adding water, the standard tablet hardness of dry paste powder can only be increased to 29N, which cannot meet the formability requirements of dry granulation. It shows that increasing the water content of dry paste powder by p...

Embodiment 3

[0027] Tortoise shell glue formula granule dry paste powder 100kg, water content 1.8%, dry granulation formability is very low, dry paste powder standard tablet hardness 28N. Weigh 5 kg of colloidal silicon dioxide with a water content of 2.5%. Calculate according to the water content of 5.0% in the dry cream powder after mixing, spray 3.50 kg of purified water into the colloidal silicon dioxide, stir and mix evenly, and form a powder wet state. Then add the wetted colloidal silica into the dry paste powder of tortoise shell glue, stir and mix evenly, the formability of dry granulation is obviously improved, and the standard tablet hardness of the dry paste powder increases to 176N. When only colloidal silica is added without adding water, the standard tablet hardness of dry paste powder can only be increased to 37N, which cannot meet the formability requirements of dry granulation. It shows that the wetting of the powder increases the water content of the dry paste powder is...

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Abstract

The invention relates to a method for improving dry granulation formability of traditional Chinese medicine formula granules through powder wetting. The method comprises the following steps: (1) selecting proper non-water-soluble auxiliary materials; and (2) determining the water content of the non-water-soluble auxiliary material; (3) determining the adding amount of purified water, directly and uniformly spraying the purified water into the auxiliary material powder, and uniformly stirring and mixing, so that the purified water is uniformly dispersed in the auxiliary material powder; and (4) adding the dry paste powder, uniformly stirring and mixing, and then carrying out dry granulation. According to the invention, a new water adding method is adopted to replace a high-concentration ethanol method, so that the water content of the dry paste powder is increased, and the formability of the dry paste powder is improved.

Description

technical field [0001] The invention belongs to the technical field of dry granulation production of traditional Chinese medicine formula granules, and in particular relates to a method for improving the dry granulation formability of traditional Chinese medicine formula granules by wetting powder. Background technique [0002] The raw material for dry granulation of traditional Chinese medicine formula granules is dry cream powder. The drying methods of dry paste powder mainly include belt vacuum drying and spray drying. Both equipments are continuous drying and discharging methods. Affected by various factors such as steam pressure fluctuations and vacuum degree fluctuations, the materials are discharged at different times. The water content of the dry cream powder also inevitably fluctuates, so in order to avoid the water content of the dry cream powder exceeding the standard, the water content of the dry cream powder in actual production is often controlled at a lower li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61J3/00A61K47/38A61K47/24A61K47/04
CPCA61K9/1682A61J3/00A61K9/1652A61K9/1617A61K9/1611Y02A50/30
Inventor 吴建辉郑元涛石炳光徐小青王委王政旺
Owner 劲牌持正堂药业有限公司