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Surface modification method of medical material capable of resisting bacterial adhesion and application

An anti-bacterial adhesion and surface modification technology, which is applied in applications, medical science, catheters, etc., can solve the problems of complex synthesis process and separation steps, achieve improved anti-bacterial adhesion performance, green environmental protection, cost-effective, and simple preparation conditions mild effect

Active Publication Date: 2022-01-21
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although zwitterionic polymers have excellent biological properties, most zwitterionic polymers are generally synthesized by free radical polymerization of zwitterionic vinyl monomers, and the synthesis process and isolation steps are often very complicated and require later functionalization Can be used for surface fixation to form an anti-bacterial adhesion coating

Method used

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  • Surface modification method of medical material capable of resisting bacterial adhesion and application
  • Surface modification method of medical material capable of resisting bacterial adhesion and application
  • Surface modification method of medical material capable of resisting bacterial adhesion and application

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Preparation of Phosphocholined Polyvinylamine (PVAm-PC)

[0044] At 40°C, the methanol solution of aldylated glycerophosphorylcholine (PCGA) was added dropwise to the methanol solution of polyvinylamine (PVAm), wherein the molar ratio of PCGA to PVAm was 1:1, and the reaction was stirred for 24 hours to obtain reaction mixture. Sodium cyanoborohydride (NaBH 3 CN) methanol solution was added dropwise to the reaction mixture cooled to 0°C, where NaBH 3 The molar ratio of CN to PCGA was 1:1, heated to room temperature and stirred for 24 h, dialyzed with deionized water (molecular weight cut-off 500) for 3 days, and freeze-dried to obtain phosphorylcholined polyvinylamine (PVAm-PC). 1 According to H NMR, the molar percentage of X is 70%, and the molar percentage of y is 30%, that is, X / (X+y)=70%, y / (X+y)=30%. where x=770, y=330.

[0045] The prepared PVAm-PC has the following molecular structure:

[0046]

Embodiment 2

[0048] Preparation of Phosphocholined Polyvinylamine (PVAm-PC)

[0049] At 55°C, the methanol solution of aldylated glycerophosphorylcholine (PCGA) was added dropwise to the methanol solution of polyvinylamine (PVAm), wherein the molar ratio of PCGA to PVAm was 1:0.5, and the reaction was stirred for 24 hours to obtain reaction mixture. Sodium cyanoborohydride (NaBH 3 CN) methanol solution was added dropwise to the reaction mixture cooled to 0°C, where NaBH 3 The molar ratio of CN to PCGA was 1:1, heated to room temperature and stirred for 24 h, dialyzed with deionized water (molecular weight cut-off 500) for 3 days, and freeze-dried to obtain phosphorylcholined polyvinylamine (PVAm-PC). 1 H NMR records that the molar percentage of X is 60%, and the molar percentage of y is 40%, that is, X / (X+y)=60%, y / (X+y)=40%, wherein X=660 , y=440.

Embodiment 3

[0051] Preparation of Phosphocholined Polyvinylamine (PVAm-PC)

[0052] At 55°C, the methanol solution of aldylated glycerophosphorylcholine (PCGA) was added dropwise to the methanol solution of polyvinylamine (PVAm), wherein the molar ratio of PCGA to PVAm was 1:0.1, and the reaction was stirred for 24 hours to obtain reaction mixture. Sodium cyanoborohydride (NaBH 3 CN) methanol solution was added dropwise to the reaction mixture cooled to 0°C, where NaBH 3 The molar ratio of CN to PCGA was 1:0.5, heated to room temperature and stirred for 24 hours, dialyzed with deionized water (molecular weight cut-off 500) for 3 days, and freeze-dried to obtain phosphorylcholined polyvinylamine (PVAm-PC). 1 H NMR records that the molar percentage of X is 40%, and the molar percentage of y is 60%, that is, X / (X+y)=40%, y / (X+y)=60%, wherein X=440 , y=660.

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Abstract

The invention belongs to the technical field of material surface modification, and discloses a surface modification method of a medical material capable of resisting bacterial adhesion and application. Through PVAm-PC and KH560 reaction, trimethoxysilane phosphorylated polyvinylamine is prepared, and then the trimethoxysilane phosphorylated polyvinylamine is utilized to modify the medical material to obtain the medical material capable of resisting bacterial adhesion. The trimethoxysilane can be hydrolyzed and activated to form silanol, a silanol group is dehydrated to form a covalent bond, a cross-linking reaction is carried out to form a phosphorylcholine-based zwitterionic coating, and an inorganic network structure of the phosphorylcholine-based zwitterionic coating can fix phosphorylcholine polyvinylamine on the surface of the medical material to achieve the purpose of surface modification. In addition, the zwitterionic polymer adsorbs water through electrostatic interaction in a physiological environment to form a hydration layer. Therefore, good antibacterial adhesion is achieved, and the phosphorylcholine group can improve biocompatibility, so that the modified medical material is non-toxic to normal cells and has remarkable broad-spectrum antibacterial adhesion performance under a physiological environment condition.

Description

technical field [0001] The invention belongs to the technical field of material surface modification, and in particular relates to a method and application of a surface modification method for anti-bacterial adhesion of medical materials. Background technique [0002] When medical materials are used clinically, the anti-bacterial adhesion performance of the material surface is very important. If bacteria adhere to the surface of medical materials, microbial biofilms become a major obstacle to the use of medical materials, triggering inflammatory host responses and posing a serious threat to the health of patients. In recent years, various antimicrobial surfaces have been designed to reduce the risk of infection caused by microbial colonization, which can be divided into three categories according to the mechanism of action: antibacterial surfaces, static and dynamic antibacterial surfaces. The antiseptic surface is the surface containing antibacterial agents, such as quater...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L24/00A61L24/06A61L31/10A61L31/14C08F8/42C08F8/40C08F126/02
CPCA61L29/085A61L29/14A61L24/0036A61L24/001A61L24/06A61L31/10A61L31/14C08F8/42C08F8/40C08L39/02C08F126/02
Inventor 曾戎曹惠屠美
Owner JINAN UNIVERSITY
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