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Amphiphilic block polymer nanoparticles with different morphologies as well as preparation method and application of amphiphilic block polymer nanoparticles

An amphiphilic block and nanoparticle technology, applied in the field of polymers, can solve problems such as complex processes, and achieve the effects of simple process, short polymerization reaction time, and suitability for industrial production.

Active Publication Date: 2022-02-01
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above method needs to be prepared through "two pots and two steps", and the process is complicated

Method used

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  • Amphiphilic block polymer nanoparticles with different morphologies as well as preparation method and application of amphiphilic block polymer nanoparticles
  • Amphiphilic block polymer nanoparticles with different morphologies as well as preparation method and application of amphiphilic block polymer nanoparticles
  • Amphiphilic block polymer nanoparticles with different morphologies as well as preparation method and application of amphiphilic block polymer nanoparticles

Examples

Experimental program
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preparation example Construction

[0036] The invention provides a method for preparing amphiphilic block polymer nanoparticles with different morphologies, comprising the following steps:

[0037] Stable segment monomers, nucleating segment monomers, Lewis acids, Lewis bases and aromatic solvents are mixed, and the resulting mixed reaction solution is polymerized to obtain amphiphilic block polymer nanoparticles with different morphologies.

[0038] In the present invention, unless otherwise specified, all raw material components are commercially available products well known to those skilled in the art.

[0039] In the present invention, the stable segment monomer is an acrylate monomer, preferably including dimethylaminoethyl acrylate (DMAEA), diethylaminoethyl acrylate (DEAEA), methyl acrylate (MA) ethyl acrylate (EA), butyl acrylate (BA), 2-methoxyethyl acrylate (MEA) or 2-ethylhexyl acrylate (2-EHA). In the present invention, the nucleating segment monomers include trifluoroethyl methacrylate (TFEMA), 2,...

Embodiment 1

[0049] At room temperature, DMAEA and TFEMA were added to toluene at the same time, Lewis acid was added for pre-mixing for 2 minutes, and then Lewis base was added, and the resulting mixed reaction solution was polymerized for 18 minutes to obtain a solution of amphiphilic block polymer nanoparticles. After the morphology of the amphiphilic block polymer nanoparticles in the solution, add n-hexane to the solution of the amphiphilic block polymer nanoparticles to quench and filter, and use n-hexane to wash the resulting solid product 3 times and then drain it , to obtain amphiphilic block polymer nanoparticles (denoted as PDMAEA 75 -b-PTFEMA 265 , wherein, 75 and 265 represent the degree of polymerization), and then carry out subsequent characterization and testing.

[0050] Among them, the Lewis base is Lewis acid as BHTAl i Bu 2 The solid content of the mixed reaction solution is 15%; the molar ratio of Lewis base: Lewis acid: DMAEA: TFEMA = 1:2:75:265.

Embodiment 2～7

[0052] Prepare amphiphilic block polymer nanoparticles according to the method of Example 1, and the preparation conditions are as shown in Table 1:

[0053] Table 1 Preparation conditions of Examples 1-7

[0054]

[0055]

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Abstract

The invention provides amphiphilic block polymer nanoparticles with different morphologies as well as a preparation method and application thereof, belonging to the technical field of polymers. Under the catalytic action of a Lewis acid-base pair, an acrylate monomer stable chain segment monomer and a nucleation chain segment monomer are subjected to a polymerization reaction, and the amphiphilic block polymer nanoparticles with different morphologies are obtained; and the nucleating chain segment monomer comprises trifluoroethyl methacrylate or benzyl methacrylate. According to the invention, the Lewis acid-base pair is used as a catalyst, so highly asymmetric amphiphilic block polymer nanoparticles with different morphologies can be efficiently synthesized through a one-pot one-step method, and the polymer nanoparticles are clear in structure, few in monomer insertion errors, good in polymerization controllability and narrow in molecular weight distribution. The amphiphilic block polymer nanoparticles with spherical morphology, worm morphology and vesicle morphology can be obtained by controlling the dosage ratio of the two monomers.

Description

technical field [0001] The invention relates to the technical field of polymers, in particular to amphiphilic block polymer nanoparticles with different shapes and their preparation methods and applications. Background technique [0002] The self-assembly of amphiphilic block copolymers in solution is a powerful method for the synthesis of polymeric nanomaterials. Traditional solution self-assembly requires firstly synthesizing and purifying block polymers, and then dispersing them in selective solvents. , using selective solvents for the differences in the solubility of each block in the amphiphilic block polymer and the difference in the relative proportion of each block to obtain assemblies such as spheres and vesicles, but this method requires extremely low assembly concentrations (<1%) and the complicated "polymer synthesis + post-polymerization assembly" process, these shortcomings greatly limit its practical application in industry. [0003] The emergence of the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F297/00
CPCC08F297/00
Inventor 张越涛李城锴何江华
Owner JILIN UNIV
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