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Selenium-doped prussian blue nano-enzyme for regulating intestinal cells to treat colitis, preparation method and application thereof

A technology of Prussian blue and cell therapy, applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of high preparation cost and low catalytic activity, achieve simple method, inhibit T cell differentiation, and improve the ability to scavenge active oxygen and the effect of kind

Active Publication Date: 2022-02-25
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the inflammatory response of various cells in the inflammatory part of the colon and the problems of high preparation cost and low catalytic activity of traditional nanozymes, the present invention constructs a selenium-doped Prussian blue nanozyme for regulating intestinal cells to treat enteritis

Method used

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  • Selenium-doped prussian blue nano-enzyme for regulating intestinal cells to treat colitis, preparation method and application thereof
  • Selenium-doped prussian blue nano-enzyme for regulating intestinal cells to treat colitis, preparation method and application thereof
  • Selenium-doped prussian blue nano-enzyme for regulating intestinal cells to treat colitis, preparation method and application thereof

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Embodiment 1

[0036] The present embodiment prepares selenium-doped Prussian blue nanozyme as follows:

[0037] (1) Dissolve 3.0g of PVP in 30mL of HCL solution with a concentration of 0.01M, then add 132mg of potassium ferricyanide powder, and stir until evenly mixed; the resulting mixture is placed in an oven at 80°C for 24h; after the reaction, 14000rpm Centrifuge for 10 min, wash with water 3 times, and freeze-dry to obtain Prussian blue powder (PB NCs).

[0038](2) Dissolve 30mg of Prussian blue powder in 30mL of 1M HCL solution, then add 300mg of PVP, stir at room temperature for 3h, then place in an oven at 140°C for 3h; after the reaction, centrifuge at 14000rpm for 10min, and wash with water 3 times and freeze-drying to obtain hollow mesoporous Prussian blue powders (HMPB NCs).

[0039] (3) Add an equal volume of 6mg / mL sodium selenite solution to the 2mg / mL hollow mesoporous Prussian blue aqueous dispersion, stir and react at room temperature for 30 minutes, then slowly add the s...

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Abstract

The invention discloses selenium-doped prussian blue nano-enzyme for regulating intestinal cells to treat colitis, a preparation method and application thereof, wherein a layer of selenium is doped on the surface of hollow mesoporous prussian blue by a hard template method. The selenium-doped prussian blue nano-enzyme disclosed by the invention has a good capability of removing active oxygen and a function of inhibiting intestinal epithelial cell lipid peroxidation and T cell differentiation, and can be used for relieving the occurrence of intestinal inflammatory diseases.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a preparation method of a selenium-doped Prussian blue nanozyme for regulating intestinal cells and treating colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology affecting the colon and rectum. The cause of UC is multifactorial, including genetic background, environment, and imbalance of mucus immune regulation, which are all important causes of intestinal inflammation. Chronic inflammation in patients with colitis will not only lead to abdominal pain and diarrhea, but also lead to the destruction of the gastrointestinal epithelial barrier, the imbalance of cell types and intestinal microbial flora in the colon, and the appearance of these symptoms will significantly reduce the Quality of Life. UC has now grown into a global burden, with a large impact on developed countries and a substantia...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K33/04A61K9/16A61P1/00A61P1/04A61P39/06A61P29/00B82Y5/00B82Y40/00
CPCA61K33/26A61K33/04A61K9/167A61K9/1682A61P1/00A61P1/04A61P39/06A61P29/00B82Y5/00B82Y40/00A61K2300/00
Inventor 查正宝朱东东
Owner HEFEI UNIV OF TECH
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