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High-pressure processing method of prepared rehmannia root

A Rehmannia glutinosa, high-pressure technology is applied in the directions of medical preparations, pharmaceutical formulations, and plant raw materials containing active ingredients, which can solve the problems of loss of active ingredients and long processing time of Rehmannia glutinosa, and achieve the effect of ensuring product quality.

Pending Publication Date: 2022-02-25
河北仁心药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a high-pressure processing method of Rehmannia glutinosa to solve the problems of the prior art that the processing time of Rehmannia glutinosa is too long and the loss of active ingredients is large

Method used

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  • High-pressure processing method of prepared rehmannia root
  • High-pressure processing method of prepared rehmannia root
  • High-pressure processing method of prepared rehmannia root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 chromatographic condition investigation

[0016] 1. Preparation of the test solution

[0017] Weigh 0.1g of rehmannia glutinosa powder, weigh it accurately, add 25mL of 50% methanol, weigh, heat to reflux for 30 minutes, let cool to room temperature, use 50% methanol to make up the lost weight, and filter through a 0.22μm microporous membrane.

[0018] 2. Preparation of reference solution

[0019] Accurately weigh 4.44, 4.40, 6.02, and 3.49 mg of catalpol, 5-HMF, rehmandin D, and verbascoside in 10 ml volumetric flasks, and dilute to the volume with methanol water (50:50, v / v) ultrapure water. Scale line, sonicate to dissolve completely, and prepare mixed reference substance solutions with concentrations of 0.444, 0.44, 0.602, and 0.349 mg / ml, respectively.

[0020] 3. Chromatographic conditions

[0021] Methanol-water gradient elution (the method is shown in Table 1 below); the flow rate is 1.0 mL / min; the detection wavelength is 210 nm; the column temp...

Embodiment 2

[0041] Embodiment 2 high pressure steaming method twice

[0042] Take raw rehmannia glutinosa, put it in a pressure cooker, set the steaming temperature to 120°C, steam for 10 minutes first, then add 40% water to soak for 4 hours, steam again for 10, 20, 30, and 40 minutes respectively, and the steaming is completed. Take out, slice, dry, measure the content of above-mentioned 4 compositions by the method for embodiment 1. The results are shown in Table 4.

[0043] Table 4:

[0044]

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Abstract

The invention provides a high-pressure processing method of prepared rehmannia root, which specifically comprises the following steps: placing raw rehmannia root in a pressure cooker, setting the steaming temperature to 110-125 DEG C, and conducting steaming for 8-12 minutes; and adding water or yellow wine for soaking for 3-5 hours, conducting steaming for 20-40 minutes at 110-125 DEG C, taking out the steamed rehmannia root after steaming, conducting slicing, and conducting airing to obtain the prepared rehmannia root. The rehmannia root processing technology is optimized, high-pressure secondary steaming is adopted, the rehmannia root is firstly steamed once, then soaked with water or yellow wine and finally steamed once again. The first steaming accelerates the absorption of water, and the water permeates into the rehmannia root as soon as possible, so that the rehmannia root is completely soaked, and the time of the second steaming is greatly shortened.

Description

technical field [0001] The invention belongs to the technical field of processing traditional Chinese medicinal materials, and in particular relates to a high-pressure processing method of Rehmannia glutinosa. Background technique [0002] Rehmannia glutinosa is a large number of commonly used Chinese medicinal materials in clinical practice. It comes from the fresh or dried roots of Rehmannia glutinosa Libosch., a plant of the family Scrophulariaceae. Its commonly used medicinal forms are: fresh rehmannia, raw rehmannia, rehmannia glutinosa, raw rehmannia charcoal, rehmannia glutinosa, etc., and different processing forms have different properties, flavors and effects. Fresh Rehmannia glutinosa is cold in nature, sweet and bitter in taste, clears heat and promotes body fluid, cools blood to stop bleeding; Rehmannia glutinosa mainly contains iridoid glycosides, phenylethanol glycosides, furan aldehyde derivatives and other compounds. This application selects the representat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804G01N30/02A61K125/00
CPCA61K36/804G01N30/02A61K2236/10
Inventor 解伟松高红凤
Owner 河北仁心药业有限公司
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