Preparation method of oxygen-producing particles of calcium peroxide coated with polylactic acid-glycolic acid copolymer
A glycolic acid copolymer, calcium peroxide technology, applied in medical science, prosthesis, etc., can solve difficult to meet the needs of tissue regeneration, oxygen-producing particles without good biocompatibility and degradability, oxygen-producing time maintenance, etc. question
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0020] 1) Exissue the polylactic acid-hydroxyacetic acid copolymer in dichloromethane to prepare 10 ml of 5% (w / v) PLGA solution; dissolve gelatin in deionized water to prepare 150 ml of 1% (w / v) gelatin solution; 2 Add 1 ml 2% (w / v) CaO in deionized water 2 Suspension;
[0021] 2) CAO prepared by step 1) 2 The suspension is mixed with a PLGA solution and homogeneous treatment to obtain the first mixture;
[0022] 3) In the gelatin solution prepared in step 1), the first mixture prepared in step 2 is added to obtain a second mixture, and the second mixed liquid homogen is treated with the heating magnetic stirrer to heat it for 4 hours to evaporate removal. The remaining dichloromethane was centrifuged to discard the supernatant, and the oxygen-oxidant particles were washed.
[0023] The specific steps of the sediment washing process in the step 3) are as follows:
[0024] a) Place the precipitate in a test tube containing 30 ml of methanol, mix well for 60 seconds, stand fo...
Embodiment 2
[0029] 1) Dissolve the polylactic acid-hydroxyacetic acid copolymer in dichloromethane to prepare 10 ml of 4.5% (w / v) PLGA solution; dissolve gelatin in deionized water to prepare 150 ml of 1% (w / v) gelatin solution; 2 Add 1 ml 1.5% (w / v) CAO in deionized water 2 Suspension;
[0030] 2) CAO prepared by step 1) 2 The suspension is mixed with a PLGA solution and homogeneous treatment to obtain the first mixture;
[0031] 3) In the gelatin solution prepared in step 1), the first mixture prepared in step 2 is added to obtain a second mixture, and the second mixed liquid homogen is treated with the heating magnetic stirrer to heat it for 3 hours to evaporate removal. The remaining dichloromethane was centrifuged to discard the supernatant, and the oxygen-oxidant particles were washed.
[0032] The specific steps of the sediment washing process in the step 3) are as follows:
[0033] a) Place the precipitate in a test tube containing 30 ml of methanol, mix well for 60 seconds, sta...
Embodiment 3
[0037] 1) Dissolve the polylactic acid-hydroxyacetic acid copolymer in dichloromethane to prepare 10 ml of 5.5% (w / v) PLGA solution; dissolve gelatin in deionized water to prepare 150 ml of 2% (w / v) gelatin solution; 2 Add 1 mL 2.5% (w / v) CAO in deionized water 2 Suspension;
[0038] 2) CAO prepared by step 1) 2 The suspension is mixed with a PLGA solution and homogeneous treatment to obtain the first mixture;
[0039] 3) In the gelatin solution prepared in step 1), the first mixture prepared in step 2 is added to obtain a second mixture, and the second mixed liquid homogen is treated with the heating magnetic stirrer to heat it for 4 hours to evaporate removal. The remaining dichloromethane was centrifuged to discard the supernatant, and the oxygen-oxidant particles were washed.
[0040] The specific steps of the sediment washing process in the step 3) are as follows:
[0041]a) Place the precipitate in a test tube containing 30 ml of methanol, mix well for 60 seconds, stan...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More