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Preparation method of high-biocompatibility alpha-tricalcium phosphate nano-powder for 3D printing

A tricalcium phosphate nano, biocompatible technology, applied in prosthesis, medical science, additive processing, etc., can solve the problems of enhancing adhesion, increasing cell space, and the biocompatibility needs to be further improved. Achieve the effect of mild production conditions and low energy consumption costs

Pending Publication Date: 2022-03-08
ZHONGSHAN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the improvement made by this technical solution is only to simply increase the space for accommodating cells and enhance the adhesion, and does not fundamentally solve the problem of promoting cell proliferation itself, and its biocompatibility needs to be further improved
[0009] Second, it is difficult to prepare high-purity α-TCP by using the existing technology, and it is difficult to store it stably for a long time at room temperature
However, whether it is a dry process or a wet process, some α-TCP phases will change into β-TCP during the rapid cooling and storage stages, which will seriously affect the quality of α-TCP and subsequent clinical applications.

Method used

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  • Preparation method of high-biocompatibility alpha-tricalcium phosphate nano-powder for 3D printing
  • Preparation method of high-biocompatibility alpha-tricalcium phosphate nano-powder for 3D printing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation method of the highly biocompatible α-tricalcium phosphate nanopowder for 3D printing described in Example 1 is prepared according to the following steps from the following raw material components in parts by mass:

[0052] (1) First, 0.1 part of Ce(NO 3 ) 3 , 30 parts of tetraisopropyl titanate, 5 parts of sodium chloride and 500 parts of pure water are added to the hydrothermal reaction kettle and fully stirred evenly, and then 20 parts of Ca(NO 3 ) 2 And fully stir evenly, then airtightly raise the temperature to 120°C and keep it warm for 30 minutes; then stop the reaction and cool down to room temperature to discharge, first filter the reaction solution and wash it with alcohol, and then roast the collected filter cake at 120°C for 10 minutes, that is Negatively charged phyllosilicate 1# was obtained.

[0053] (2) Next, add 0.1 part of negatively charged phyllosilicate 1# prepared in the above step (1), 300 parts of calcium carbonate and 1000 part...

Embodiment 2

[0055] The preparation method of the highly biocompatible α-tricalcium phosphate nanopowder for 3D printing described in Example 2 is prepared according to the following steps from the following raw material components in parts by mass:

[0056] (1) First, 0.25 parts of Ce 2 (SO 4 ) 3 , 0.25 parts Dy(NO 3 ) 3 , 30 parts of tetrabutyl titanate, 30 parts of tetrabutyl titanate, 5 parts of sodium chloride and 500 parts of pure water are added to the hydrothermal reaction kettle and fully stirred evenly, and then 25 parts of Ca(NO 3 ) 2 and 25 parts CaCl 2 And fully stir evenly, then airtightly raise the temperature to 150°C and keep it warm for 60 minutes; then stop the reaction and cool down to room temperature to discharge, first filter the reaction solution and wash it with alcohol, and then roast the collected filter cake at 150°C for 30 minutes, that is Negatively charged phyllosilicate 2# was obtained.

[0057] (2) Next, add 0.5 parts of negatively charged phyllosili...

Embodiment 3

[0059] The preparation method of the highly biocompatible α-tricalcium phosphate nanopowder for 3D printing described in Example 3 is prepared according to the following steps from the following raw material components in parts by mass:

[0060] (1) First, 0.07 parts of CeCl 3 , 0.15 copies of Dy 2 (SO 4 ) 3 , 0.09 parts of DyCl 3 , 13 parts of tetrabutyl titanate, 26 parts of tetraisopropyl titanate, 5 parts of sodium chloride and 500 parts of pure water are added to the hydrothermal reaction kettle and fully stirred evenly, and then 11 parts of Ca(NO 3 ) 2 and 20 parts CaCl 2 And fully stir evenly, then airtightly raise the temperature to 130°C and keep it warm for 40 minutes; then stop the reaction and cool down to room temperature to discharge, first filter the reaction solution and wash it with alcohol, and then roast the collected filter cake at 130°C for 15 minutes, that is Negatively charged phyllosilicate 3# was prepared.

[0061] (2) Next, add 0.3 parts of the...

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Abstract

The preparation method of the high-biocompatibility alpha-tricalcium phosphate nano-powder for 3D printing comprises the following steps: S1, hydrothermal reaction: mixing rare earth, a titanium source and a cosolvent in a solvent, adding calcium salt, and carrying out hydrothermal reaction; s2, roasting: cooling the product, washing and filtering, and roasting a filter cake; s3, hydrothermal reaction: dispersing the electronegative layered silicate and calcium carbonate in a solvent, adding strong phosphoric acid, and carrying out hydrothermal reaction; and S4, roasting: cooling the product, filtering and washing to obtain a filter cake, roasting the filter cake, and grinding after roasting to obtain the alpha-tricalcium phosphate nano-powder. The problem of poor biocompatibility of an alpha-TCP / 3D printed bone finished product is creatively and thoroughly solved by introducing the electronegative layered lamellar crystals. The biocompatibility and the mechanical property of a bone finished product taking the alpha-TCP nano-powder as a powder forming material are far better than those of alpha-TCP similar products produced in the prior art or imported from abroad, and the bone finished product has extremely bright biomedical application prospects.

Description

technical field [0001] The invention relates to the technical field of preparation of 3D printing materials, and more specifically, to a preparation method of highly biocompatible α-tricalcium phosphate nanopowder for 3D printing. Background technique [0002] Bone defect is a common clinical problem in orthopedics around the world. There are about 100 million patients with bone defect or bone injury caused by various accidents and diseases every year in the world, and there are more than 200 million people with unsound bones. Most bone defects cannot heal on their own and require bone repair surgery. With the aging of the population and the increase of various traumas, the demand for bone repair materials is also increasing. [0003] Among the bone repair materials, calcium phosphate cement (CPC) can be arbitrarily shaped according to the bone defect, and has incomparable advantages such as self-solidification in the body, so it is an ideal bone repair material. It has be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B12/02A61L27/12B33Y70/00
CPCC04B12/025B33Y70/00A61L27/12
Inventor 聂建华王俊侯勇江常胜余明君李金盛李彩凤
Owner ZHONGSHAN POLYTECHNIC
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