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Propamidine and hinokitiol compound composition, bactericide and application

A technology for compounding compositions and compounding fungicides, applied in the directions of fungicides, applications, biocides, etc., can solve the problems of increased resistance frequency and resistance level of pathogenic bacteria, and achieve the effect of good control effect.

Active Publication Date: 2022-03-18
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the repeated use of the above-mentioned agents in large quantities, the frequency and level of resistance of pathogenic bacteria to the above-mentioned agents are gradually increasing.
For example, Botrytis cinerea has produced different levels of resistance to most of the agents registered in production for the control of Botrytis cinerea, and the problem of multiple resistance is becoming more and more serious

Method used

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  • Propamidine and hinokitiol compound composition, bactericide and application
  • Propamidine and hinokitiol compound composition, bactericide and application
  • Propamidine and hinokitiol compound composition, bactericide and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Indoor and in vitro determination of the toxicity of propamidine and hinokitiol

[0042] The toxicity of propaneamidine and hinokitiol to pathogenic bacteria was determined by mycelial growth rate method. Dissolve the original propaneamidine in methanol to 5000, 2500, 1250, 625, 312.5, 156.2 and 78.125ug / ml; dissolve hinoki alcohol in methanol to 25000, 12500, 6250, 3125, 1562.5, 781.25 and 390.625ug / ml; Bactazim was dissolved with 0.2M hydrochloric acid to 500, 250, 125, 62.5 and 31.25ug / ml. Draw above-mentioned mother liquor 0.2mL and add 100mL PDA culture medium with pipette gun respectively, make the drug-containing culture medium that final concentration is respectively 10, 5, 2.5, 1.25, 0.625 and 0.3125ug / ml propaneamidine; Final concentration is respectively 50, 25, 12.5, 6.25, 3.125, 1.5625 and 0.78125ug / ml hinoki alcohol in the drug-containing medium; the final concentrations were 1, 0.5, 0.25, 0.125, and 0.0625ug / ml carbendazim in the drug-contain...

Embodiment 2

[0052] Embodiment 2: the synergistic effect of propaneamidine and Hinokitiol different proportioning

[0053] Using the reference mycelial growth rate method, the toxicity of propaneamidine and hinokitiol to pathogenic bacteria were determined in different proportions

[0054] The bacteria cake was transferred to a PDA plate containing a series of concentration compound agents, and cultured at 25°C for 2 constant temperature cultures. When the colony diameter of the blank control group exceeded 2 / 3 of the diameter of the entire culture dish, the diameter of all colonies was measured, and each treatment was repeated 3 times, and the mycelial growth inhibition rate and the effective inhibitory concentration (EC 50 ), calculate the synergistic coefficient of the mixed agent according to the following formula. When the synergy coefficient is greater than 1.5, it is a synergistic effect; between 0.5 and 1.5, it is an additive effect; when it is less than 0.5, it is an antagonistic...

Embodiment 3

[0062] Embodiment 3: the production of 15% propaneamidine and 15% Hinokitiol composition aqueous emulsion A

[0063] Accurately and quantitatively weigh 167 kilograms of the former drug of 90% propaneamidine, and then weigh 160 kilograms of the former drug of 94% hinoki alcohol. Mix the two active ingredients in 2M 3 Mix thoroughly in the mixing tank. Accurately weigh 10 kg of ascorbic acid, put it into the blending tank, and mix thoroughly again. Then accurately add 80 kg of emulsifier Well201, 10 kg of gum arabic, 10 kg of urea, 10 kg of sorbic acid and 500 kg of ethyl acetate into the blending tank, add to make up to 1000 kg, and fully mix in the blending tank. Stirring was continued for 1 hour. The water emulsion product of 1 ton of propaneamidine and hinokitiol composition is prepared.

[0064] Sampling analysis shows that the content of propaneamidine is 15%, and the content of hinokitiol is 15%. The product is divided into aluminum cans coated with barrier material...

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Abstract

The invention provides a compound composition of propamidine and hinokitiol, a bactericide and application. The mass ratio of propamidine to hinokitiol is (1-8): (2-1). The propamidine and the natural product hinokitiol are compounded, so that not only can the sclerotinia rot of colza and the gray mold of fruits and vegetables be prevented and treated, but also the composition can be used for treating the sclerotinia rot of colza and the gray mold of fruits and vegetables which have drug resistance to benzimidazole and dicarboximide bactericides. The binary compound agent is used for preventing and treating drug-resistant sclerotinia rot of colza and gray mold of fruits and vegetables, the synergistic effect is obvious, the dosage of the agent can be obviously reduced, and the compound agent is expected to be developed into a new generation of green agricultural bactericide.

Description

technical field [0001] The invention belongs to the field of agricultural fungicides, and in particular relates to a compound composition of propaneamidine and hinokitiol, a fungicide and its application. The combination of these two compounds is used to control rape sclerotinia, fruit and vegetable gray mold, and the control of rape sclerotinia and fruit and vegetable gray mold that have become resistant to benzimidazole and dicarboximide fungicides The method belongs to the invention of a new use of a fungicide and its application technology. Background technique [0002] Crop diseases cause huge economic losses to agricultural production every year. At this stage, chemical control is still an important means of plant disease control. However, due to the long-term repeated use of chemical pesticides, the problems of pathogenic bacteria resistance and pesticide residues have become increasingly prominent. Nowadays, people are paying close attention to green food and envi...

Claims

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Application Information

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IPC IPC(8): A01N37/52A01N35/06A01N25/14A01P3/00
CPCA01N37/52A01N35/06A01N25/14Y02A50/30
Inventor 王勇吴华陈光友蔡崇林闫合冯俊涛马志卿
Owner NORTHWEST A & F UNIV
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