Arformoterol tartrate orally disintegrating tablet and preparation method thereof
A technology of tartaric acid and orally disintegrating tablets, applied in the field of medicine, can solve the problems of low content uniformity, poor fluidity, and low deposition of effective parts
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Embodiment 1
[0019]
[0020] Preparation Process:
[0021] 1) Arformoterol tartrate is pulverized and pretreated, and the particle size is 60 μm.
[0022] 2) Pass mannitol 100SD, microcrystalline cellulose PH101, crospovidone and acesulfame potassium through a 60-mesh sieve and mix for 3 times.
[0023] 3) Use purified water as a wetting agent to make a soft material, and granulate with a 30-mesh nylon sieve.
[0024] 4) Dry at 50°C until the moisture content of the granules is less than 3%, and sieve the granules with a 30-mesh steel sieve.
[0025] 5) To calculate the yield of the granulated granules, first add croscarmellose sodium, acesulfame potassium, menthol, and silicon dioxide and mix for 3 minutes. After mixing evenly, add magnesium stearate and mix for 1 minute.
[0026] 6) Use a φ7mm flat punch to press the tablet, the tablet weight is 150mg, the difference in the tablet is ±5%, and the hardness is 20-40N.
Embodiment 2
[0028]
[0029] Preparation Process:
[0030] 1) Arformoterol tartrate is pulverized and pretreated, and the particle size is 10 μm.
[0031] 2) Pass mannitol 100SD, microcrystalline cellulose PH101, crospovidone and acesulfame potassium through a 60-mesh sieve and mix for 3 times.
[0032] 3) Use purified water as a wetting agent to make a soft material, and granulate with a 30-mesh nylon sieve.
[0033] 4) Dry at 50°C until the moisture content of the granules is less than 3%, and sieve the granules with a 30-mesh steel sieve.
[0034] 5) To calculate the yield of the granulated granules, first add croscarmellose sodium, acesulfame potassium, menthol, and silicon dioxide and mix for 3 minutes. After mixing evenly, add magnesium stearate and mix for 1 minute.
[0035] 6) Use a φ7mm flat punch to press the tablet, the tablet weight is 150mg, the difference in the tablet is ±5%, and the hardness is 20-40N.
Embodiment 3
[0037]
[0038] Preparation Process:
[0039] 1) Arformoterol tartrate is pulverized and pretreated, and the particle size is 80 μm.
[0040] 2) Pass mannitol 100SD, microcrystalline cellulose PH101, crospovidone and acesulfame potassium through a 60-mesh sieve and mix for 3 times.
[0041] 3) Use purified water as a wetting agent to make a soft material, and granulate with a 30-mesh nylon sieve.
[0042] 4) Dry at 50°C until the moisture content of the granules is less than 3%, and sieve the granules with a 30-mesh steel sieve.
[0043] 5) To calculate the yield of the granulated granules, first add croscarmellose sodium, acesulfame potassium, menthol, and silicon dioxide and mix for 3 minutes. After mixing evenly, add magnesium stearate and mix for 1 minute.
[0044] 6) Use a φ7mm flat punch to press the tablet, the tablet weight is 150mg, the difference in the tablet is ±5%, and the hardness is 20-40N.
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