Characterization method of pharmaceutical co-crystal performance

Abstract

The invention discloses a characterization method of pharmaceutical co-crystal performance. Terahertz spectrum and wavelet Raman spectrum of carbamazepine-nicotinamide pharmaceutical co-crystal are respectively measured by using a terahertz time-domain spectroscopy system and a wavelet Raman spectrum system. By analyzing the position, shape, strength and other characteristics of the characteristic peak, the intermolecular interaction, lattice vibration and other low-frequency vibration information in the pharmaceutical co-crystal are researched. According to the method, two low-frequency vibration spectrums of the absorption spectrum and the excitation spectrum are combined, the Raman and infrared characteristics of the pharmaceutical co-crystal can be researched from the molecular perspective, and an effective means is provided for obtaining rich pharmaceutical co-crystal information in the pharmaceutical field.

Description

technical field [0001] The invention relates to the field of low-frequency infrared and Raman characteristic characterization of drug co-crystals, in particular to a method for characterizing the properties of drug co-crystals. Background technique [0002] Drug co-crystal is a new type of supramolecular compound formed by the complexation between the active ingredient of the drug and the co-crystal former through weak non-covalent bonds such as hydrogen bonds. Pharmaceutical co-crystals have significant application value in the field of pharmaceuticals. They can modify the physical properties of active pharmaceutical ingredients, such as melting point, stability, solubility, and bioavailability, without changing the chemical structure. [0003] As a common antiepileptic and antineuropathic pain psychotropic drug, carbamazepine has the disadvantages of low solubility, slow oral absorption and insufficient absorption of its main active ingredients. Oral drug properties of ma...

AI Technical Summary

Problems solved by technology

[0003] As a common antiepileptic and antineuropathic pain psychotropic drug, carbamazepine has the disadvantages of low solubility, slow oral absorption and insufficient absorption of its main active ingredients. Mazepine Oral Drug Properties

X-ray diffraction and thermal analysis, as commonly used methods for the characterization of drug co-crystals, have the advantages of simplicity and accuracy, but at the same time there are disadvantages such as no chemical information and destructive to samples.

Raman spectrum (200cm -1 -2000cm -1 ) and infrared spectroscopy are based on the vibration and / or rotation of intramolecular chemical bonds, which cannot reflect low-frequency information such as intermolecular interactions and lattice vibrations.

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