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Content determination method for children type Kaihoujian spray by quantitative analysis of multi-components by single marker

A method of determination, the technology of open throat sword, applied in the field of content determination with one test and multiple evaluations, can solve the problems of less research on quality control, and achieve the effects of easy mastery, reduced testing cost, and reduced testing time

Pending Publication Date: 2022-03-18
贵州三力制药股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few studies on the quality control of Kaihoujian spray

Method used

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  • Content determination method for children type Kaihoujian spray by quantitative analysis of multi-components by single marker
  • Content determination method for children type Kaihoujian spray by quantitative analysis of multi-components by single marker
  • Content determination method for children type Kaihoujian spray by quantitative analysis of multi-components by single marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1: Simultaneous determination of 4 components in Kaihoujian spray by one-test and multiple-evaluation method

[0073] (1) Preparation of reference substance solution: Precisely weigh 20.26 mg of matrine reference substance, 20.06 mg of petracenin reference substance, and 10.36 mg of pterostaloside reference substance in 10 mL volumetric flasks, respectively, and place macaine reference substance 10.23mg was placed in a 25mL volumetric flask, and methanol was added to ultrasonically dissolve and the volume was adjusted to the mark, shaken well, and used as the reference substance stock solution; mL, placed in the same 10mL volumetric flask and distilled to volume with methanol to prepare mixed reference solution with concentrations of 0.7091mg / mL, 0.8024mg / mL, 0.1036mg / mL, and 0.02456mg / mL;

[0074] (2) Preparation of the test solution: Precisely draw 2.5mL of Kaihoujian spray and place it in a 5mL volumetric flask, add methanol to the volume, shake well, and the...

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Abstract

The invention discloses a method for determining the content of Kaihoujian spray (children type). The method for determining the content of sophocarpidine, bergenin, trifoliate pterocarpin and macaine in the Kaihoujian spray (children type) by adopting high performance liquid chromatography is established, and the content of Kaihoujian spray (children type) is determined by taking bergenin as an internal standard substance. The detection result is accurate and stable, and the method can be used for quality control of Kaihoujian spray (children type); meanwhile, the detection cost and the detection time can be reduced, the workload can be reduced, the efficiency can be improved, and a foundation is laid for improving the quality standard of kaihoujian spray (children type).

Description

technical field [0001] The invention relates to a detection method of traditional Chinese medicine preparations, in particular to a content determination method of Kaihoujian spray (children's type) with one test and multiple evaluations. Background technique [0002] Kaihoujian Spray (Children's Type) is an exclusive large variety of Miao medicine produced by Guizhou Sanli Pharmaceutical Co., Ltd. Its prescription is composed of Octopus, Shandougen, cicada slough, and menthol. It has the functions of clearing heat, detoxifying, and reducing swelling Analgesic effect. Clinically, it has a significant curative effect in the treatment of children with acute pharyngitis, acute tonsillitis, herpetic stomatitis, herpetic angina, hand, foot and mouth disease, and thrush, with high safety and no side effects. At present, there are few studies on the quality control of Kaihoujian spray. According to the research and analysis of its components, petracenin is the main effective chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74G01N30/86
CPCG01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/74G01N30/8675G01N2030/324Y02A50/30
Inventor 张海周英王珏犇俸婷婷张丽艳石慧董秀
Owner 贵州三力制药股份有限公司
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