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Application of forsythin in preparation of fatty triglyceride lipase inhibitor

A lipase inhibitor and triglyceride technology, applied in the field of biomedicine, can solve problems such as side effects and poor effect, and achieve the effect of clear effect, reducing gene expression and protein level, and inhibiting the basic lipolysis reaction of adipose tissue

Pending Publication Date: 2022-03-25
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to solve the problem that the existing inhibitors of fat triglyceride lipase are not effective and have side effects, and provide the application of forsythin in the preparation of inhibitors of fat triglyceride lipase

Method used

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  • Application of forsythin in preparation of fatty triglyceride lipase inhibitor
  • Application of forsythin in preparation of fatty triglyceride lipase inhibitor
  • Application of forsythin in preparation of fatty triglyceride lipase inhibitor

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Embodiment Construction

[0018] The above and other technical features and advantages of the present invention will be described in more detail below in conjunction with the accompanying drawings.

[0019] 1. Experimental animals

[0020] SPF grade male healthy C57BL / 6J male mice were used, all 4 weeks old, provided by Jiangsu Jicui Yaokang Biotechnology Co., Ltd., license number: SCXK (Su) 2012-0001. The animals were raised at SPF level, with a constant temperature of 18-22°C and a constant humidity of 55%-65%. They were raised in the SPF-level animal room of the Experimental Animal Center of the College of Integrated Traditional Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine. The animal experiment design was approved by Anhui University of Traditional Chinese Medicine. The Experimental Animal Ethics Committee agreed. During the experiment, pay attention to observe the mouse's body activity, hair color, record the death of the animal, monitor the body weight, food int...

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Abstract

The invention relates to the technical field of biomedicine, in particular to application of phillyrin in preparation of a fatty triglyceride lipase inhibitor, the phillyrin is used for reducing serum free fatty acid and glycerol levels of high-fat fed mice, inhibiting adipose tissue base lipolysis reaction and reducing gene expression and protein levels of ATGL, and molecular docking experiments show that the phillyrin can be used for preparing the fatty triglyceride lipase inhibitor. The phillyrin can be combined with ATGL protein, and an inhibition effect is generated.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of forsythin in the preparation of fat triglyceride lipase inhibitors. Background technique [0002] Forsythia was first recorded in Volume 3 of "Shen Nong's Materia Medica", and it was listed as a lower grade. It said: "Forsythia is called Yiqiao, Lanhua, Zhegen, Zhe, and Sanlian. It grows in the valley." Its taste is bitter, slightly cold in nature. Return lung, heart, small intestine meridian, mainly produced in my country's Shanxi, Henan, Shaanxi, Shandong and other places. The 2020 edition of "Pharmacopoeia of the People's Republic of China" records that Forsythia is the dried fruit of Forsythiasuspensa (Thunb.) Vahl, a plant of Oleaceae. In autumn, the fruit is harvested when it is still green when it is first ripe, and impurities are removed, steamed, and dried in the sun. It has the effects of clearing heat and detoxifying, reducing swelling and dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/634A61P3/00A61K131/00
CPCA61K31/7048A61K36/634A61P3/00
Inventor 童小慧杨佩佩赵娜娜周晨宇韩荣春吕燕萍
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE