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Anti-infection fermented product and preparation method, product and application thereof

A fermented product and anti-infection technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, antifungal agents, etc., can solve the problems of no penetration, achieve high bioavailability, efficient preparation methods, and scientific formulations reasonable effect

Pending Publication Date: 2022-03-25
哈尔滨求真生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dermatophytes have the ability to invade keratinous tissue skin, hair, and nails, but are usually confined to the inanimate keratin layer of the epidermis because they do not have the ability to penetrate the living tissue of an immunocompetent host

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The first step is to prepare superfine powder: 8kg of dried black fungus, 6kg of rice bran, 6kg of hawthorn, 6kg of Phellodendron cork, 6kg of black soybean, and 8kg of lotus seed. Crushed into superfine powder with a particle size below 10 μm, set aside.

[0031] The second step is to prepare the seed solution of the fermented strain: the medium contains 0.3% beef extract, 1.0% tryptone, and 0.5% NaCL. The activated Bacillus subtilis, Bifidobacterium lactis, and Lactobacillus plantarum were inoculated at a ratio of 1:1:1, and the inoculum amount was 2%, respectively. They were mixed and cultivated at 36°C for 12 hours to prepare the seed liquid of the fermented strain and set aside.

[0032] The third step prepares the fermentation substrate: according to the weight of the superfine powder obtained in the first step, add 5 times of water to the fermenter, keep it for 5 minutes after boiling, stop heating, cool down, and obtain the fermentation substrate for future use....

Embodiment 2

[0036] The first step is to prepare superfine powder: take 4kg of dried black fungus, 10kg of rice bran, 2kg of hawthorn, 10kg of Phellodendron cork, 2kg of black beans, 12kg of lotus seeds, and 2kg of coix seed. Crushed into superfine powder with a particle size below 10 μm, set aside.

[0037] The second step is to prepare the seed solution of the fermented strain: the medium contains 0.2% beef extract, 1.2% tryptone, and 0.4% NaCL. The activated Bacillus subtilis, Bifidobacterium lactis, and Lactobacillus plantarum were inoculated at a ratio of 1:1:1, and the inoculum amount was 1%, respectively, and mixed cultured at 42°C for 5 hours to prepare the seed liquid of the fermented strain and set aside.

[0038] The third step is to prepare the fermentation substrate: according to the weight of the superfine powder obtained in the first step, add 7 times of water to the fermenter, keep it for 7 minutes after boiling, stop heating, cool down, and obtain the fermentation substrat...

Embodiment 3

[0042] The first step is to prepare superfine powder: take 12kg of dried black fungus, 2kg of rice bran, 10kg of hawthorn, 2kg of Phellodendron cork, 10kg of black beans, 4kg of lotus seeds, and 10kg of coix seed. Crushed into superfine powder with a particle size below 10 μm, set aside.

[0043] The second step is to prepare the seed solution of the fermented strain: the medium contains 0.4% beef extract, 0.8% tryptone, and 0.6% NaCL. The activated Bacillus subtilis, Bifidobacterium lactis, and Lactobacillus plantarum were inoculated at a ratio of 1:1:1, and the inoculum amount was 3%, respectively, and mixed cultured at 30°C for 20 hours to make a seed solution of the fermented strain and set aside.

[0044] The third step prepares the fermentation substrate: according to the weight of the superfine powder obtained in the first step, add 3 times of water into the fermenter, keep it for 3 minutes after boiling, stop heating, cool down, and obtain the fermentation substrate fo...

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PUM

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Abstract

The invention provides an anti-infection fermented product as well as a preparation method, a product and application thereof, and belongs to the technical field of biological fermentation. On the first aspect, the invention provides an anti-infection fermentation product, and the anti-infection fermentation product comprises the following raw materials: black fungus, rice bran, hawthorn, golden cypress, black beans, lotus seeds and coix seeds; on the second aspect, the invention provides a preparation method of the anti-infection fermentation product; thirdly, the invention provides a product of the anti-infection fermented product; in the fourth aspect, the invention also provides an anti-infection fermentation product and application of the anti-infection fermentation product to dermatophytosis removal.

Description

technical field [0001] The invention relates to the technical field of biological fermentation. Specifically, it relates to an anti-infection fermented product and its preparation method, product and application. Background technique [0002] Athlete's foot is caused by fungi, the main fungus is Trichophyton rubrum. Trichophyton rubrum is the most common pathogenic dermatophyte with worldwide distribution, and it is also the most common dermatophyte in my country. Trichophyton rubrum can cause skin, hair, and nail infections, and often causes chronic, refractory infections of the feet and nails. According to research statistics, it can lead to chronic infection circles in dermatophytosis, and the culture-positive rate reaches 67%. When dermatophyte infects humans, hair, nails and keratinous tissue of the skin become the material basis for its growth and metabolism. Dermatophytes have the ability to invade keratinous tissue skin, hair, and nails, but are usually confined ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/48A61K36/62A61K36/734A61K36/756A61K36/07A61K9/14A61P31/10A61P17/00
CPCA61K36/07A61K36/899A61K36/734A61K36/756A61K36/48A61K36/62A61K9/14A61P17/00A61P31/10A61K2236/19A61K2300/00
Inventor 孔祥辉崔璨孔令圳
Owner 哈尔滨求真生物科技有限公司