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Preparation method of drug-loaded mesoporous calcium silicate modified PMMA (polymethyl methacrylate) bone cement as well as product and application of drug-loaded mesoporous calcium silicate modified PMMA bone cement

A technology of calcium silicate and bone cement, which is applied in silicate, alkaline earth metal silicate, medical science, etc., can solve the problems that limit the development and application of bone repair, and achieve the promotion of biocompatibility and osteogenesis, Effect of lowering the modulus of elasticity and expanding the range of applications

Active Publication Date: 2022-03-29
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the exothermic polymerization during the curing process of PMMA bone cement, it is often difficult to apply bioactive drugs such as protein peptides that are not resistant to high temperatures to the modification of PMMA bone cement, which limits its further development and application in bone repair.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A drug-loaded mesoporous calcium silicate modified PMMA bone cement, prepared according to the following steps:

[0039] (1) Preparation of mesoporous calcium silicate:

[0040] Mix 390mL of deionized water, 60mL of nitric acid, and 9g of surfactant P123, and stir until the solution is clear to obtain an aqueous solution; add 25.5g of tetraethyl orthosilicate and 28.8g of calcium nitrate tetrahydrate to the above aqueous solution, and react under stirring in a water bath at 38°C 24 hours; After the reaction, after the solvent was evaporated by rotary evaporation at 60°C, the product was calcined in a muffle furnace at 600°C for 6 hours, and then the naturally cooled product was wet ball milled with ethanol as a medium at a speed of 400rpm, and ball milled for 2-4 hours. Hours, 45 ℃ rotary evaporation and drying, after passing through a 300-mesh sieve, to obtain mesoporous calcium silicate powder;

[0041] (2) Preparation of drug-loaded mesoporous calcium silicate

[0...

Embodiment 2

[0048] Other steps and proportions are the same as in Example 1, except that the SVVYGLR polypeptide is replaced by silk fibroin to prepare drug-loaded mesoporous calcium silicate modified PMMA bone cement.

Embodiment 3

[0050] Other steps and proportions were the same as in Example 1, except that the SVVYGLR polypeptide was replaced with VEGF to prepare drug-loaded mesoporous calcium silicate-modified PMMA bone cement.

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Abstract

The invention relates to a preparation method of drug-loaded mesoporous calcium silicate modified PMMA bone cement as well as a product and application of the drug-loaded mesoporous calcium silicate modified PMMA bone cement. The preparation method comprises the steps of preparation of mesoporous calcium silicate, preparation of drug-loaded mesoporous calcium silicate, gelatin coating treatment and preparation of the modified PMMA bone cement. The gelatin-coated drug-loaded mesoporous calcium silicate is used as a drug carrier and a filler, so that the biocompatibility and osteogenic ability of the PMMA bone cement can be promoted, and the elastic modulus of the bone cement is reduced; the gelatin absorbs heat to accelerate the dissolution rate in water, the bioactive drug is crosslinked and fixed in mesopores, and under the protection of gelatin coating, the bioactive drug can be prevented from being inactivated due to polymerization heat release, so that the clinical application range of the bone cement is expanded.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a preparation method of drug-loaded mesoporous calcium silicate-modified PMMA bone cement and its product and application. Background technique [0002] Osteoporosis (OP) is a common systemic bone metabolic disease, characterized by low bone mass and damage to bone microstructure, which can easily lead to non-traumatic fractures. Osteoporotic vertebral compression fractures (osteoporotic vertebral compression fractures, OVCFs) are the most common osteoporotic fractures, accounting for about 45% of osteoporotic fractures. Percutaneous vertebroplasty (PVP) is the most commonly used minimally invasive technique for the treatment of OVCFs. At present, the commonly used filling bone cement in PVP is PMMA bone cement. The bone cement has high mechanical strength, but has a large elastic modulus and is not Possesses osteogenic bioactivity. Some scholars focus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/16A61L27/02A61L27/56A61L27/22C01B33/24
CPCA61L27/54A61L27/16A61L27/025A61L27/56A61L27/222C01B33/24A61L2430/02A61L2300/412A61L2300/416C08L33/12
Inventor 崔大祥杨迪诚朱君余将明
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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