Lipid nanogold particle compound and application thereof in delivering ERG and treating encephaledema disease
A technology of gold nanoparticles and composites, applied in gene therapy, genetic material components, pharmaceutical formulations, etc., can solve the problem of less brain edema, achieve the effects of treating brain edema, repairing the blood-brain barrier, and facilitating large-scale production
Pending Publication Date: 2022-04-05
QIANFOSHAN HOSPITAL OF SHANDONG
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Abstract
The invention relates to the technical field of gene therapy, relates to a lipid gold nanoparticle compound and application of the lipid gold nanoparticle compound to ERG delivery and encephaledema disease treatment, and provides a lipid gold nanoparticle compound for treating encephaledema through a gene therapy method. The composite material comprises an Ang1-Lipo-AuNP-ERG compound, wherein the Ang1-Lipo-AuNP- The preparation method of the compound comprises the following specific steps: preparation of the AuNPs, preparation of the cation AuNPs, preparation of the AuNP-ERG, and preparation of the Ang1-Lipo-AuNP-ERG. The preparation method has the beneficial effects that the lipid gold nanoparticle compound Ang1-Lipo-AuNP-ERG serving as the gene carrier of the ERG has good biocompatibility and relatively high delivery efficiency. When Ang1-Lipo-AuNP-ERG is taken in by brain endothelial cells, ERG plasmids are expressed in the cells, so that the expression of Claudin-5, VE-Cadherin and ICAM-1 is regulated and controlled, and the effects of repairing the blood brain barrier and treating encephaledema can be achieved.
Application Domain
Genetic material ingredientsGene therapy
Technology Topic
CadherinGene carrier +8
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