Preparation method of nasal spray

Abstract

The invention relates to a preparation method of a nasal spray, which comprises the following steps of: preparing and shearing a suspension base solution, namely I, weighing purified water according to the prescription dosage, putting the purified water into a mixing tank A, starting stirring, keeping the rotating speed at 50 revolutions per minute, adding anhydrous dextrose, stirring to dissolve, and visually detecting that the solution is clear; 2, continuously stirring, slowly adding microcrystalline cellulose-sodium carboxymethyl cellulose, and continuously stirring until the solution is free of caking and wall sticking phenomena through visual inspection; 3, opening the batching tank A to connect with a shearing machine, opening the batching tank B to connect with a corresponding valve of the shearing machine and on-line shearing equipment, and carrying out cyclic pre-shearing; the total mixing and shearing step comprises the following steps: 1, adding other dissolved components into a mixing tank A under the condition of stirring, and continuously stirring for 10 minutes; and 2, opening the batching tank A to connect with the shearing machine, opening the batching tank B to connect with a corresponding valve of the shearing machine and on-line shearing equipment, and carrying out on-line circulating shearing. The nasal spray disclosed by the invention is high in component dispersity and rapid in production.

Description

Technical field [0001] The present invention relates to the field of preparation of a spray, and more particularly to a method of preparing a nasal spray. Background technique [0002] As a nasal spray, the dispersion of various components is important. When the nasal spray is produced, the cellulose which is solid at room temperature is a substance that the nasal spray production process requires a large amount of material, which is difficult to disperse. Common, in the purified water of the fiber is placed, natural swelling, stirred, stirred, which will be around 24 hours; resulting in the preparation cycle of the entire nasal spray preparation, and the dispersion is not good, and the appearance is not aggregated. Suspension liquid, which is uniform, thixped; microscopic observation: The distribution is substantially uniform, there is still a micro-group, and the raw material microcompallite is very small. For the above problems, the present invention provides a solution. Inve...

AI Technical Summary

Problems solved by technology

Commonly, the cellulose is placed in the purified water of the prescribed amount, naturally swollen, stirred and sieved, which will take about 24 hours; it will lead to a prolonged preparation period of the entire nasal spray, and the dispersion effect is not good. Visual appearance: no aggregation of raw materials, It is a uniformly dispersed suspension with thixotropy; microscopic observation: the distribution is basically uniform, there are still a small amount of agglomeration, and the raw material is slightly aggregated and a small amount of flow phenomenon