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Eye wash containing schizophyllan and preparation method thereof

A technology of schizophyllan and eyewash, which is applied in the field of medicine, can solve the problems of general antibacterial and anti-inflammatory effects, and achieve the effects of moisturizing dry eyes, relieving dry eyes, enhancing comfort and lubricating feeling

Active Publication Date: 2022-04-08
GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hyaluronic acid has good moisturizing properties, it has general antibacterial and anti-inflammatory effects, and it is inevitable to add other auxiliary agents: surfactants (such as benzalkonium chloride) and functional ingredients (such as taurine , vitamins) etc.

Method used

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  • Eye wash containing schizophyllan and preparation method thereof
  • Eye wash containing schizophyllan and preparation method thereof
  • Eye wash containing schizophyllan and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] This embodiment provides an eyewash solution containing Schizophyllan, said eyewash solution containing Schizophyllan comprises the following components in terms of mass percentage:

[0057]

[0058] The preparation method of the eyewash solution containing Schizophyllan comprises the following steps:

[0059] (1) Mix and stir the Schizophyllan and water at 80° C. at a speed of 200 rpm for 10 minutes according to the above ratio, so as to completely dissolve the Schizophyllan and obtain a uniform Schizophyllan solution;

[0060] (2) First cool down the Schizophyllan solution obtained above to 45°C, then add gellan gum, poloxamer 407, and hydroxypropyl methylcellulose in sequence, stir at 100 rpm for 8 minutes, and then cool down to 30°C Add ectoine and stir at 200 rpm for 8 minutes, and finally add an osmotic pressure regulator and stabilizer and stir at 200 rpm for 3 minutes to obtain an eyewash solution containing Schizophyllan with a pH of 6.5 and an osmotic press...

Embodiment 2

[0062] This embodiment provides an eyewash solution containing Schizophyllan, said eyewash solution containing Schizophyllan comprises the following components in terms of mass percentage:

[0063]

[0064] The preparation method of the eyewash solution containing Schizophyllan comprises the following steps:

[0065] (1) Mix and stir the Schizophyllan and water at 75° C. at a speed of 200 rpm for 12 minutes according to the above ratio, so that the Schizophyllan is completely dissolved, and a uniform Schizophyllan solution is obtained;

[0066] (2) First cool down the Schizophyllan solution obtained above to 45°C, then add gellan gum, poloxamer 188, and hydroxypropyl methylcellulose in sequence, stir at 100 rpm for 8 minutes, and then cool down to 30°C Add ectoine and stir at 200 rpm for 8 minutes, and finally add osmotic pressure regulator and stabilizer and stir at 200 rpm for 3 minutes to obtain a Schizophyllan-containing eyewash solution with a pH of 6.6 and an osmotic ...

Embodiment 3

[0068] This embodiment provides an eyewash solution containing Schizophyllan, said eyewash solution containing Schizophyllan comprises the following components in terms of mass percentage:

[0069]

[0070] The preparation method of the eyewash solution containing Schizophyllan comprises the following steps:

[0071] (1) Mix and stir Schizophyllan and water at 70° C. at a speed of 300 rpm for 20 minutes according to the above-mentioned ratio to completely dissolve Schizophyllan and obtain a uniform Schizophyllan solution;

[0072] (2) First cool down the Schizophyllan solution obtained above to 45°C, then add gellan gum, poloxamer 188, and hydroxypropyl methylcellulose in sequence, stir at 100 rpm for 5 minutes, and then cool down to 28°C Add ectoine and stir for 10 minutes at 100 rpm, and finally add an osmotic pressure regulator and stir for 10 minutes at 100 rpm to obtain an eyewash solution containing Schizophyllan with a pH of 6.3 and an osmotic pressure of 300 mOsm / L....

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Abstract

The invention provides eye wash containing schizophyllan and a preparation method of the eye wash. The eye wash containing the schizophyllan is prepared from the schizophyllan, Ectoine, an ophthalmic gel matrix, an osmotic pressure regulator and water. The eye washing liquid containing schizophyllan is used for washing eyes, including eye peripheries and eyeball surfaces, and can be used for removing dust, particles, pollen and other foreign matters or secretions; and the eye washing liquid has the capabilities of relieving eye fatigue and aching pain, resisting radiation, moisturizing, relieving eye dryness, eliminating inflammation and inhibiting bacteria, and has excellent effects on eye visual fatigue, eye dryness, eye acerbity and other symptoms caused by long-time wearing of contact lenses.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an eyewash solution containing schizophyllan and a preparation method thereof. Background technique [0002] The eye is a part exposed to the air for a long time, and at the same time it is a relatively fragile part of the human body. Long-term exposure to dust, smog, and cosmetics will inevitably cause various eye diseases. The cornea is located at the forefront of the human eye, and the corneal structure is divided into epithelial layer, Bowman's membrane, stroma layer, Bowman's membrane and endothelial layer. A large number of sensory nerves are distributed on the cornea, which is one of the most sensitive positions of the human body. The use of eyewash can relieve eye discomfort and eye dryness to a certain extent, because eyewash has the functions of cooling and relieving itching, promoting eye nutrition, keeping eyes moist and hygienic, and avoiding conjunctiva...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K31/505A61K9/00A61K47/32A61K47/36A61K47/38A61K47/10A61P27/02A61P29/00A61P31/02A61P31/04A61P31/10
Inventor 裴运林胡露孙怀庆聂艳峰王宁王丽华魏瑞敬
Owner GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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