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Super-assembled polyethylene glycol/silicon dioxide nano sensing probe as well as preparation method and application thereof

A technology of silica and polyethylene glycol, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of complicated probe preparation methods, unadjustable detection function, and limited detection sensitivity, and achieve improved hydrophilicity , adjustable function and simple synthesis method

Pending Publication Date: 2022-04-12
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the detection and adsorption of heavy metal ions has been realized by using microdispersed silica. However, the current research has always faced some problems, such as limited detection sensitivity, complicated probe preparation methods, and unadjustable detection functions.

Method used

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  • Super-assembled polyethylene glycol/silicon dioxide nano sensing probe as well as preparation method and application thereof
  • Super-assembled polyethylene glycol/silicon dioxide nano sensing probe as well as preparation method and application thereof
  • Super-assembled polyethylene glycol/silicon dioxide nano sensing probe as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of 2MI-P@MSN nano-probe specifically includes the following steps:

[0039] Step 1: Prepare a mesoporous material (MSN) with ordered channels based on the sol-gel method.

[0040] Step 2: Soak the prepared MSN mesoporous material in anhydrous toluene and 3-aminopropyltriethoxysilane (APTES) solution at 80° C. for 2 hours.

[0041] Step 3: Wash the mesoporous material three times with toluene and methanol respectively to remove excess unreacted APTES.

[0042] Step 4: Dry at room temperature to obtain aminated MSN mesoporous material (MSN-NH 2 ).

[0043] Step 5: Dissolving salicylaldehyde in a mixed solution of tris(2-aminoethyl)amine and ethanol was refluxed and stirred for 5 hours to prepare a zinc ion probe (PZn).

[0044] Step 6: cooling the prepared zinc ion probe, washing with ethanol and filtering to obtain the final yellow precipitate (PZn).

[0045] Step 7: Add MSN-NH 2 Add PZn and 2MI mixed methanol solution, and then ultrasonically...

Embodiment 2

[0051] The preparation method of 2MI-P@MSN nano-probe specifically includes the following steps:

[0052] Step 1: Prepare a mesoporous material (MSN) with ordered channels based on the sol-gel method.

[0053] Step 2: Soak the prepared MSN mesoporous material in anhydrous toluene and 3-aminopropyltriethoxysilane (APTES) solution at 60° C. for 3 h.

[0054] Step 3: Wash the mesoporous material three times with toluene and methanol respectively to remove excess unreacted APTES.

[0055] Step 4: Dry at room temperature to obtain aminated MSN mesoporous material (MSN-NH 2 ).

[0056] Step 5: Dissolving salicylaldehyde in a mixed solution of tris(2-aminoethyl)amine and ethanol was condensed under reflux and stirred for 6 hours to prepare a zinc ion probe (PZn).

[0057] Step 6: cooling the prepared zinc ion probe, washing with ethanol and filtering to obtain the final yellow precipitate (PZn).

[0058] Step 7: Add MSN-NH 2 Add PZn and 2MI mixed methanol solution, and then ultr...

Embodiment 3

[0061] The preparation method of 2MI-P@MSN nano-probe specifically includes the following steps:

[0062] Step 1: Prepare a mesoporous material (MSN) with ordered channels based on the sol-gel method.

[0063] Step 2: Soak the prepared MSN mesoporous material in anhydrous toluene and 3-aminopropyltriethoxysilane (APTES) solution at 90° C. for 1 h.

[0064] Step 3: Wash the mesoporous material three times with toluene and methanol respectively to remove excess unreacted APTES.

[0065] Step 4: Dry at room temperature to obtain aminated MSN mesoporous material (MSN-NH 2 ).

[0066] Step 5: Dissolving salicylaldehyde in a mixed solution of tris(2-aminoethyl)amine and ethanol was refluxed and stirred for 2 hours to prepare a zinc ion probe (PZn).

[0067] Step 6: cooling the prepared zinc ion probe, washing with ethanol and filtering to obtain the final yellow precipitate (PZn).

[0068] Step 7: Add MSN-NH 2 Add PZn and 2MI mixed methanol solution, and then make it uniformly ...

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Abstract

The invention relates to a super-assembled polyethylene glycol / silicon dioxide nano sensing probe as well as a preparation method and application thereof, the probe takes monodisperse silicon dioxide as a carrier, a zinc ion probe and 2-methylimidazole are loaded on the carrier, and the carrier is sequentially modified by amination and polyethylene glycol. Compared with the prior art, the nano-probe has the advantages of simple synthesis method, adjustable function, biodegradability and the like, and is beneficial to the application of the nano-probe in the field of biomedical detection.

Description

technical field [0001] The invention relates to the technical field of micro-nano sensing analysis, in particular to a super-assembled polyethylene glycol / silicon dioxide nano-sensing probe and its preparation method and application. Background technique [0002] In recent years, artificial intelligence nanoprobes with controllable size and surface functions have been widely used in biomedical detection. Its application and detection in the human body should have characteristics such as biocompatibility. Based on this, mesoporous silica nanoparticles have a fixed pore structure, stable skeleton, easily modified surface and good biocompatibility. It has attracted widespread attention, especially because it can encapsulate drug molecules and probe molecules in its pores, which greatly improves the performance in the biomedical field. In addition, the rich porosity and high specific surface area of ​​monodisperse silica also expand its application in adsorption. [0003] In r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C09K11/02
Inventor 孔彪黄亚楠何彦君曾洁
Owner FUDAN UNIV
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