Magnetic targeting hydrophobic drug carrier hydrogel as well as preparation method and application thereof

A technology for hydrophobic drugs and hydrogels, which can be used in pharmaceutical formulations, liquid delivery, plant raw materials, etc., can solve the problems of short drug release time and the inability of hydrogel decomposition products to be well absorbed by the human body. Wound recovery, universal, low-cost effect

Pending Publication Date: 2022-05-24
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current performance of hydrogels suitable for hydrophobic drugs still has defects, such as short drug release time, hydrogel decomposition products cannot be well absorbed by the body, and cannot well meet the needs of patients.

Method used

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  • Magnetic targeting hydrophobic drug carrier hydrogel as well as preparation method and application thereof
  • Magnetic targeting hydrophobic drug carrier hydrogel as well as preparation method and application thereof
  • Magnetic targeting hydrophobic drug carrier hydrogel as well as preparation method and application thereof

Examples

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preparation example Construction

[0031] The first aspect of the present invention provides a method for preparing an absorbable drug sustained-release hydrogel carrier, comprising the following steps: adding mono-6-deoxy-ethylenediamine-β-cyclodextrin (β-CD- 6-E) Add collagen to the PBS solution (pH=7.4), stir to dissolve, cool down to 2-8°C, and then mix with 2-8°C 4,5-anhydro-6(n-acetylglucosamine)- Mix the PBS solution (pH=7.4) of oxidized hyaluronic acid (ΔHA-CHO), stir quickly and evenly (about 2-3 minutes), remove the dissolved gas under appropriate pressure, pour it into the mold, and let it stand at room temperature for 24-48 hours. Get hydrogel.

[0032] In some embodiments, the schematic structure of mono-6-deoxy-ethylenediamino-β-cyclodextrin (β-CD-6-E) is as follows:

[0033]

[0034] In some embodiments, the concentration of β-CD-6-E in PBS is 0.6 mg / mL;

[0035] Type I collagen is selected as the collagen, and the primary amino group content of the collagen is 0.508mmol / g;

[0036] The mas...

Embodiment 1

[0054] Preparation of hydrogel: Dissolve 0.06g of mono-6-deoxy-ethylenediamino-β-cyclodextrin in 100mL of PBS solution (pH=7.4), add 1g of collagen, stir to dissolve, cool to 4°C, Then mixed with 4,5-anhydro-6(n-acetylglucosamine)-oxidized hyaluronic acid solution at 4℃ (1.06g 4,5-anhydro-6(n-acetylglucosamine)-oxidized hyaluronic acid Dissolve in 100mL PBS), stir rapidly (about 2-3min), remove dissolved gas under appropriate pressure, pour into a mold, and stand at room temperature for 24-48 hours to obtain hydrogel G1.

[0055] Preparation of drug-loaded hydrogel: Dissolve 0.06g of mono-6-deoxy-ethylenediamino-β-cyclodextrin in 100mL of PBS solution, and add curcumin ethanol solution dropwise under stirring (0.0159g of curcumin in 1mL ethanol), after the dropwise addition, continue to stir for 10 minutes, cool down to 4°C, then add 1g of collagen, stir for 5min, and then mix with 4,5-anhydro-6(n-acetylglucosamine)-oxidized hyaluronic acid at 4°C Acid solution mixing (1.06g ...

Embodiment 2

[0057] Preparation of hydrogel: Dissolve 0.06g of mono-6-deoxy-ethylenediamino-β-cyclodextrin in 100mL of PBS solution (pH=7.4), add 0.8g of collagen, stir to dissolve, and cool down to 4°C , and then mixed with 4,5-anhydro-6(n-acetylglucosamine)-oxidized hyaluronic acid solution at 4°C (0.866g 4,5-anhydro-6(n-acetylglucosamine)-oxidized hyaluronic acid Dissolve acid in 100mL PBS), stir rapidly (about 2-3min), remove dissolved gas under appropriate pressure, pour into a mold, and stand at room temperature for 24-48 hours to obtain hydrogel G2.

[0058] Preparation of drug-loaded hydrogel: Dissolve 0.06g of mono-6-deoxy-ethylenediamino-β-cyclodextrin in 100mL of PBS solution, and add curcumin ethanol solution dropwise under stirring (0.0159g of curcumin in 1mL ethanol), continue stirring for 10 minutes after the dropwise addition, cool down to 4°C, add 0.8g collagen, stir for 5min, and then mix with 4,5-anhydro-6(n-acetylglucosamine)-oxidized transparent Mix the hyaluronic aci...

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Abstract

The invention belongs to the field of high polymer material preparation, and relates to a magnetic targeting hydrophobic drug carrier hydrogel and a preparation method and application thereof.The preparation method comprises the steps that collagen is added into a mono-6-deoxy-ethylenediamine-beta-cyclodextrin solution, after dissolution, cooling is conducted, the collagen is mixed with a 4, 5-dehydrate-6 (n-acetylglucosamine)-oxidized hyaluronic acid solution, uniform mixing is conducted, and the magnetic targeting hydrophobic drug carrier hydrogel is obtained; and degassing, pouring into a mold, and standing to obtain the product. According to the drug-loaded hydrogel provided by the invention, the collagen and the hyaluronic acid are decomposed to generate small molecular products under the action of enzyme, the hyaluronic acid belongs to acidic mucopolysaccharide, the collagen belongs to protein, and the hyaluronic acid and the collagen can be degraded and absorbed by a human body in the presence of corresponding enzyme in the human body.

Description

technical field [0001] The invention belongs to the technical field of polymer material preparation, and in particular relates to a magnetic targeting hydrophobic drug hydrogel carrier and a preparation method and application thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] A drug carrier refers to a system that can change the way a drug enters the human body and its distribution in the body, controls the release rate of the drug, and delivers the drug to the target organ. Among drug carriers, biopolymers derived from animals, plants and microorganisms have become an important class of drug carrier materials because of their good biocompatibility, biodegradability...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L5/16C08L89/00A61K47/36A61K47/42A61K47/69A61K9/06A61K31/05A61K31/085A61K36/82A61K31/353A61K31/585A61K31/12
CPCC08J3/075C08J3/246A61K47/36A61K47/42A61K47/6951A61K9/06A61K31/05A61K31/085A61K36/82A61K31/353A61K31/585A61K31/12C08J2305/08C08J2405/16C08J2489/00
Inventor 侯昭升曲蕾王月月李祚伟秦子昊
Owner SHANDONG NORMAL UNIV
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