The invention provides hydrogel capable of loading a high-hydrophobicity
drug as well as a preparation method and application of the hydrogel, which belongs to the technical field of preparation of
high polymer materials. The preparation method comprises the following steps of firstly, preparing
cyclodextrin-terminated
polyurethane (DPU) with a
side chain containing double bonds, and carrying out click chemical crosslinking on a multi-sulfhydryl compound and the double bonds to form the
polyurethane hydrogel. The inner cavity of
cyclodextrin is hydrophobic, the outer edge of the
cyclodextrin is hydrophilic, and a hydrophobic
binding site can be provided, so that the cyclodextrin molecular cavity in the
polyurethane hydrogel can be subjected to non-
covalent binding with a high-hydrophobicity
drug, the loading of the high-hydrophobicity
drug is realized, the gel is very stable
in vitro, and under the action of an in-vivo
enzyme, the cyclodextrin
polysaccharide is gradually degraded, so that the combined
medicine is released, the hydrogel capable of loading the high-hydrophobicity drug is successfully prepared, and the hydrogel has a good practical application value.