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Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method

A calcium phosphate ceramic and composite stent technology, applied in the field of biomedical materials, can solve problems such as insufficient antibacterial properties, and achieve the effects of simple operation, satisfying diverse needs and improving biological properties

Active Publication Date: 2022-07-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is: to provide a graphene / calcium phosphate ceramic composite bracket with antibacterial function and its preparation method, to solve the shortcomings of insufficient or no antibacterial performance faced by calcium phosphate ceramics in the prior art

Method used

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  • Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method
  • Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method
  • Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method

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Embodiment 1

[0034] The present embodiment discloses the preparation method of the graphene / calcium phosphate ceramic composite stent of the present invention, specifically:

[0035] (1) Configure 0.1 mg / ml graphene solution, and immerse porous biphasic calcium phosphate ceramics (mass ratio HA:β-TCP=3:7, porosity 62%) in the graphene solution;

[0036] (2) Transfer the graphene solution containing porous calcium phosphate ceramics into a suction filter bottle, under the condition of relative vacuum degree of -0.08MPa, vacuum perfusion for 10min, take out the ceramics, dry at 60°C, and continue to put graphene after drying The graphene / calcium phosphate ceramic composite scaffold can be obtained by vacuum perfusion in the solution, drying, and repeated three times.

[0037] The stereomicrograph of the graphene / calcium phosphate ceramic composite scaffold prepared in this example is attached figure 1 (C-D), with attached figure 1 Compared with the unsupported calcium phosphate ceramic sca...

Embodiment 2

[0039] The present embodiment discloses the preparation method of the graphene / calcium phosphate ceramic composite stent of the present invention, specifically:

[0040] (1) Configure 1.0 mg / ml graphene oxide solution, and immerse porous hydroxyapatite ceramics (porosity 70%) in the graphene oxide solution;

[0041] (2) transfer the graphene oxide solution containing porous hydroxyapatite ceramics into a suction filter bottle, under the condition of relative vacuum degree-0.04MPa, vacuum perfusion for 10min, take out the ceramics, carry out freeze drying, and continue to put graphite oxide after drying The graphene / calcium phosphate ceramic composite scaffold can be obtained by vacuum perfusion in the graphene solution and freeze-drying.

[0042] The microstructure of the graphene / calcium phosphate ceramic composite scaffold prepared in this example is as follows figure 2 As shown in (A-B), it can be found that there is a graphene thin layer on the ceramic surface with a thi...

Embodiment 3

[0044] The present embodiment discloses the preparation method of the graphene / calcium phosphate ceramic composite stent of the present invention, specifically:

[0045](1) Configure a 10 mg / ml reduced graphene oxide solution, and immerse the porous tricalcium phosphate ceramic (porosity 42%) in the reduced graphene oxide solution;

[0046] (2) transfer the reduced graphene oxide solution containing porous tricalcium phosphate ceramics into the suction filter bottle, under the condition of relative vacuum degree of -0.1MPa, vacuum perfusion for 30min, take out the ceramics, carry out freeze drying, and continue to put in reduction after drying The graphene / calcium phosphate ceramic composite scaffold can be obtained by vacuum perfusion in the graphene oxide solution and freeze-drying.

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a graphene / calcium phosphate ceramic composite stent with antibacterial function and a preparation method. In the preparation method of the present invention, the porous calcium phosphate ceramic is placed in a graphene-based material solution of a certain concentration, the graphene is adsorbed on the surface and pores of the porous calcium phosphate ceramic by vacuum perfusion, and the graphene / calcium phosphate ceramic is obtained after drying treatment. Composite bracket. The graphene / calcium phosphate ceramic composite scaffold prepared by the invention not only has good osteoinductive properties, but also has good antibacterial activity, and is expected to have broad application prospects in the regeneration and repair of clinical infectious bone defects.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a graphene / calcium phosphate ceramic composite stent with antibacterial function and a preparation method. Background technique [0002] Calcium phosphate bioceramics have been widely used in the field of bone repair due to their excellent biological effects such as good biocompatibility, osteoconductivity, and osteoinductivity. Bone defects caused by clinical trauma are often accompanied by wound contamination or infection symptoms, and conventional bone repair materials often fail due to secondary infection. With the increasing clinical problem of bacterial drug resistance, higher requirements have been placed on the antibacterial properties of bone repair materials. Therefore, on the basis of optimizing the osteoinductive ability of calcium phosphate ceramics, it is of great significance to optimize the modification method to make it have both antibacterial prope...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B41/85A61L27/30A61L27/54A61L27/56
CPCC04B41/009C04B41/5001C04B41/85A61L27/303A61L27/56A61L27/54C04B35/447C04B38/00C04B41/4539C04B41/457C04B41/4515
Inventor 李向锋曹全乐吴永豪朱向东张兴栋
Owner SICHUAN UNIV
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