Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method thereof

A technology of calcium phosphate ceramics and composite scaffolds, which is applied in the field of biomedical materials, can solve the problems of insufficient antibacterial performance, and achieve the effects of simple operation, scientific design and simple method

Active Publication Date: 2021-05-04
SICHUAN UNIV
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is: to provide a graphene / calcium phosphate ceramic composite bracket with antibacterial function and its preparation method, to solve the shortcomings of insufficient or no antibacterial performance faced by calcium phosphate ceramics in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method thereof
  • Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method thereof
  • Graphene/calcium phosphate ceramic composite scaffold with antibacterial function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This embodiment discloses the preparation method of the graphene / calcium phosphate ceramic composite support of the present invention, specifically:

[0035] (1) Configure a graphene solution of 0.1 mg / ml, and immerse the porous biphasic calcium phosphate ceramics (mass ratio HA:β-TCP=3:7, porosity 62%) in the graphene solution;

[0036] (2) Transfer the graphene solution containing porous calcium phosphate ceramics to a suction filter bottle, vacuum infuse it for 10 minutes under the condition of a relative vacuum of -0.08MPa, take out the ceramics, dry at 60°C, and continue to put in graphene after drying Vacuum perfusion in the solution, drying, and repeating three times can obtain the graphene / calcium phosphate ceramic composite scaffold.

[0037] The stereomicrograph of the graphene / calcium phosphate ceramic composite support that the present embodiment makes is as attached figure 1 (C-D), with attached figure 1 (A–B) Compared with the unloaded calcium phosphate ...

Embodiment 2

[0039] This embodiment discloses the preparation method of the graphene / calcium phosphate ceramic composite support of the present invention, specifically:

[0040] (1) Configure a 1.0mg / ml graphene oxide solution, and immerse the porous hydroxyapatite ceramics (70% porosity) in the graphene oxide solution;

[0041] (2) Transfer the graphene oxide solution containing porous hydroxyapatite ceramics to a suction filter bottle, vacuum infuse it for 10 minutes under the condition of relative vacuum degree -0.04MPa, take out the ceramics, freeze-dry, and continue to put graphite oxide after drying The graphene / calcium phosphate ceramic composite scaffold can be obtained by vacuum perfusion in the graphene solution and freeze-drying.

[0042] The microstructure of the graphene / calcium phosphate ceramic composite support prepared in this embodiment is as attached figure 2 As shown in (A-B), it can be found that there is a thin layer of graphene on the ceramic surface with a thickne...

Embodiment 3

[0044] This embodiment discloses the preparation method of the graphene / calcium phosphate ceramic composite support of the present invention, specifically:

[0045](1) Configure a reduced graphene oxide solution of 10 mg / ml, and immerse the porous tricalcium phosphate ceramics (42% porosity) in the reduced graphene oxide solution;

[0046] (2) Transfer the reduced graphene oxide solution containing porous tricalcium phosphate ceramics to a suction filter bottle, vacuum infuse it for 30 minutes under the condition of relative vacuum degree of -0.1MPa, take out the ceramics, freeze-dry, and continue to put in the reduction after drying The graphene / calcium phosphate ceramic composite scaffold can be obtained by vacuum pouring into the graphene oxide solution and freeze-drying.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of biomedical materials, and discloses a graphene / calcium phosphate ceramic composite scaffold with an antibacterial function and a preparation method thereof. The preparation method comprises the following steps: placing porous calcium phosphate ceramic in a graphene-based material solution with a certain concentration, adsorbing graphene on the surface and in pores of the porous calcium phosphate ceramic through vacuum infusion, and drying to obtain the graphene / calcium phosphate ceramic composite scaffold. The graphene / calcium phosphate ceramic composite scaffold prepared by the method not only has good bone induction performance, but also has good antibacterial activity, and is expected to have a wide application prospect in clinical infectious bone defect regeneration and repair.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a graphene / calcium phosphate ceramic composite bracket with antibacterial function and a preparation method. Background technique [0002] Calcium phosphate bioceramics are widely used in the field of bone repair due to their excellent biological effects such as good biocompatibility, osteoconductivity and osteoinductivity. Bone defects caused by clinical trauma are often accompanied by wound contamination or infection symptoms, and conventional bone repair materials often fail to repair bone due to secondary infection. As the clinical problem of bacterial drug resistance becomes more and more prominent, higher requirements are put forward for the antibacterial properties of bone repair materials. Therefore, on the basis of optimizing the osteoinductive ability of calcium phosphate ceramics, it is of great significance to optimize the modification method...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C04B41/85A61L27/30A61L27/54A61L27/56
CPCC04B41/009C04B41/5001C04B41/85A61L27/303A61L27/56A61L27/54C04B35/447C04B38/00C04B41/4539C04B41/457C04B41/4515
Inventor 李向锋曹全乐吴永豪朱向东张兴栋
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com