Camel-source high-affinity nano antibody for SARS-CoV-2alpha mutant strain and SARS-CoV-2beta mutant strain
A sars-cov-2, antibody technology, applied in the direction of antibodies, antiviral agents, chemical instruments and methods, etc., can solve the problems of difficult to obtain plasma of patients who have recovered from serum therapy, and the amount is small, and achieves simple pretreatment process, high neutralization Ability, high sensitivity effect
Pending Publication Date: 2022-05-27
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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Abstract
The invention relates to a camel source high-affinity nano antibody of SARS-CoV-2 alpha mutant strain and beta mutant strain, in particular to an antibody specifically bound with S protein of coronavirus (such as SARS-CoV-2) and an antigen binding fragment of the antibody. More specifically, the present invention relates to camel-derived nanoantibodies or antigen-binding fragments thereof capable of binding with high affinity to surface S proteins of coronaviruses such as SARS-CoV-2 wild-type original strains and mutants thereof (especially B.1. 1.7 mutant strains and B.1.351 mutant strains), which can be used for the prevention, detection, diagnosis or treatment of infections caused by coronaviruses, especially SARS-CoV-2 viruses.
Application Domain
Immunoglobulins against virusesAntivirals +2
Technology Topic
AntigenMutant strain +8
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PUM
Property | Measurement | Unit |
Affinity | 5.15 ~ 25.4 | nm |
Affinity | 1.27 ~ 10.1 | nm |
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