Ion exchange compositions with water-soluble mucosal adhesive polymers
A polymer, water-soluble technology, applied in the direction of organic active ingredients, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low bioavailability of nicotine
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Embodiment 1
[0196] Preparation of ion exchange composition particles with brilliant blue color
[0197] Purified water (10 ml) was placed in a plastic beaker with a screw cap. The water-soluble anionic mucoadhesive polymer was slowly added to the water and the plastic beaker was closed with a lid, then the dispersion was stirred at about 100°C for 6 hours. 1.5 ml of 1% Brilliant Blue stock solution was added and the gel mixture was stirred vigorously at 60°C to 80°C for 1 hour. Precipitation was performed by pipetting 2 ml of the polymer gel into 30 ml of isopropyl alcohol (IPA) with a positive displacement pipette under stirring. Discard the supernatant. The pellet was washed with fresh IPA until no solvent color was observed. Residual water and IPA were evaporated from the precipitate until the structure of the product was essentially solid. The product is comminuted to a given average particle size.
Embodiment 2
[0199] Preparation of ion exchange composition particles with brilliant blue color
[0200] Purified water (10 ml) was placed in a plastic beaker with a screw cap. The water-soluble anionic mucoadhesive polymer was slowly added to the water and the plastic beaker was closed with a lid, then the dispersion was stirred at about 100°C for 6 hours. 1.5 ml of 1% Brilliant Blue stock solution was added and the gel mixture was stirred vigorously at 60°C to 80°C for 1 hour. Precipitation was performed by pipetting 2 ml of the polymer gel into 30 ml of acetone with a positive displacement pipette under stirring. Discard the supernatant. The precipitate was washed with fresh acetone until no solvent color was observed. Residual water and acetone were evaporated from the precipitate until the structure of the product was essentially solid. The product is comminuted to a given average particle size.
Embodiment 3
[0202] Preparation of ion exchange composition particles with brilliant blue color
[0203] Isopropanol (30ml) was placed in a plastic beaker with a screw cap. 3 ml of brilliant blue aqueous solution (1%) was added. The water-soluble anionic mucoadhesive polymer was slowly added to the mixture, the plastic beaker was closed with a lid, and the dispersion was stirred for 1 hour. After a 1 hour standing time to allow the powder to settle, the supernatant was decanted and discarded. Evaporation of IPA from the residue gave a fine colored polymer powder.
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