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Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof

A technology of osteoporosis and composition, which is applied in the direction of drug combination, pharmaceutical formula, and active ingredients of heterocyclic compounds, and can solve problems such as adverse reactions, poor curative effect, and poor drug safety

Active Publication Date: 2022-05-31
澳美制药(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of this application is to provide a traditional Chinese medicine composition for preventing and treating osteoporosis and its preparation method, aiming to solve the problems of poor curative effect, poor drug safety and easy adverse reactions to the body of existing drugs for treating osteoporosis to a certain extent

Method used

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  • Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating osteoporosis and preparation method thereof

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preparation example Construction

[0057] as attached figure 1 As shown, the second aspect of the embodiments of the present application provides a preparation method of a traditional Chinese medicine composition for preventing and treating osteoporosis, comprising the following steps:

[0058] S10. Obtain 300-500 parts of Epimedium and 300-400 parts of Drynariae, and extract Epimedium and Drynaria respectively to obtain Epimedium extract and Drynariae extract;

[0059] S20. Mix and granulate the Epimedium extract, Drynaria extract and 400-600 parts of urolithin A to obtain a traditional Chinese medicine composition for preventing and treating osteoporosis.

[0060] In the preparation method of the traditional Chinese medicine composition for preventing and treating osteoporosis provided in the second aspect of the embodiment of the present application, the formula amounts of Epimedium and Drynaria are extracted respectively, and after obtaining the Epimedium extract and Drynaria extract, The traditional Chine...

Embodiment 1

[0080] A traditional Chinese medicine hard capsule preparation for preventing and treating osteoporosis, its raw materials include:

[0081] Epimedium 400g, Drynaria 300g, Urolithin A 500g, the accessories are microcrystalline cellulose, silicon dioxide, magnesium stearate.

[0082] Its preparation includes the following steps:

[0083] ①Extracting Epimedium: Mix the medicinal materials of Epimedium with ethanol solution (concentration 60%) at a ratio of 1:10, heat and reflux the extract for 2 hours and then filter to obtain the filtrate extract and drug residue; add 10 times the drug residue successively Ethanol solution (concentration 60%), heated to reflux twice, 2h each time, the extract was collected by filtration; all extracts were concentrated into a small volume, maltodextrin and other auxiliary materials with a raw material amount of about 10% were added, and the concentration was continued to a density of 1.25g / ml; put the above concentrate into a vacuum drying box...

Embodiment 2

[0088] A traditional Chinese medicine tablet for preventing and treating osteoporosis, its raw materials include:

[0089] Epimedium 370g, Rhizoma Drynariae 350g, Urolithin A 450g, the accessories are microcrystalline cellulose, silicon dioxide, magnesium stearate.

[0090] Its preparation includes the following steps:

[0091] ①Extracting Epimedium: Mix the medicinal materials of Epimedium with ethanol solution (concentration 60%) at a ratio of 1:10, heat and reflux the extract for 2 hours and then filter to obtain the filtrate extract and drug residue; add 10 times the drug residue successively Ethanol solution (concentration 60%), heated to reflux twice, 2h each time, the extract was collected by filtration; all extracts were concentrated into a small volume, maltodextrin and other auxiliary materials with a raw material amount of about 10% were added, and the concentration was continued to a density of 1.25g / ml; put the above concentrate into a vacuum drying box, vacuum ...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating osteoporosis and a preparation method thereof. The traditional Chinese medicine composition for preventing and treating osteoporosis is prepared from the following raw material medicines in parts by weight: 300 to 500 parts of herba epimedii, 300 to 400 parts of rhizoma drynariae and 400 to 600 parts of urolithin A. According to the traditional Chinese medicine composition for preventing and treating osteoporosis, through the synergistic compounding effect of the three raw material medicines, bone metabolism can be synergistically adjusted, bone resorption is inhibited, bone formation is promoted, then the bone density is increased, and the effects of preventing and treating osteoporosis of middle-aged and elderly people and promoting bone health of the middle-aged and elderly people are jointly achieved.

Description

technical field [0001] The application belongs to the technical field of medicines, and in particular relates to a traditional Chinese medicine composition for preventing and treating osteoporosis and a preparation method thereof. Background technique [0002] Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass and damage to bone microstructure, resulting in increased bone fragility and susceptibility to fractures. Osteoporosis is divided into two categories: primary and secondary. Primary osteoporosis includes postmenopausal osteoporosis (type I), senile osteoporosis (type II) and idiopathic osteoporosis. osteoporosis (including juvenile form). Primary osteoporosis is more common in postmenopausal women and older men. There are usually no obvious clinical manifestations in the initial stage. As the disease progresses, bone mass is continuously lost, and patients will experience pain, spinal deformation, and osteoporotic fractures in severe ca...

Claims

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Application Information

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IPC IPC(8): A61K36/296A61P19/10A61K31/37
CPCA61K36/296A61K36/126A61K31/37A61P19/10A61K2300/00
Inventor 张尚书康樱樱
Owner 澳美制药(苏州)有限公司
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