Determination method for anti-infective drugs in cosmetics

A measurement method and anti-infection technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of illegal addition of anti-infection drugs, not covering commonly used clinical drugs, mutation of bacterial gene structure, etc., to achieve the promotion of ionization efficiency, Protection of consumer health, high selectivity effect

Pending Publication Date: 2022-06-03
ZHEJIANG INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some manufacturers may illegally add anti-infective drugs to acne-removing cosmetics in order to pursue good effects of rapid sterilization and acne removal
Existing studies have shown that anti-infective drugs have cell mutagenicity and animal carcinogenic toxicity, and long-term use of anti-infective drugs will cause serious consequences, which may induce human body flora imbalance, cause allergic phenomena such as contact dermatitis, and in severe cases will cause Visceral damage, mutations in bacterial genetic structure and development of drug resistance
[0003] At present, the detection methods of illegally added anti-infective drugs in cosmetics mainly include high-performance liquid chromatography (HPLC) diode array detector method, gas chromatography (GC), gas chromatography-tandem mass spectrometry (GC-MS / MS) and high-performance liquid chromatography (HPLC). Phase chromatography-tandem mass spectrometry (LC-MS / MS), etc., have relatively few types of determination, do not cover some commonly used clinical drugs, and the pretreatment method is too simple, which is prone to false positive results

Method used

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  • Determination method for anti-infective drugs in cosmetics
  • Determination method for anti-infective drugs in cosmetics
  • Determination method for anti-infective drugs in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A method for the determination of anti-infective drugs in cosmetics, such as Figure 1-7 shown, including the following steps:

[0057] S1: prepare measuring materials and measuring instruments;

[0058] S2: prepare a standard solution for determination;

[0059] S3: Preparation and determination of 3 blank matrix solutions;

[0060] S4: Determine the reference conditions for instrument measurement: chromatographic conditions and mass spectrometry conditions;

[0061] S5: Use QC samples for parameter verification;

[0062] S6: Sample determination: screening of 37 anti-infective drugs in cosmetics;

[0063] S7: Calculate and establish a database: establish a compound library of 37 anti-infective drugs that may be added to cosmetics.

[0064] The test substances include 37 kinds of anti-infective drugs that may be added in anti-acne / anti-acne cosmetics;

[0065] Preferably, the 37 kinds of anti-infective drugs include metronidazole (100%), sulfapyridine (100%), sul...

Embodiment 2

[0095] A method for the determination of anti-infective drugs in cosmetics, such as Figure 1-7 As shown, in order to reduce the interference of the matrix and improve the accuracy of the measurement, this example makes the following supplements on the basis of Example 1: the selective verification method includes the following steps:

[0096] Aa: Select 3 representative blank matrices for creams, emulsions, and aqueous blanks, respectively, for sample injection and determination;

[0097] Ab: At the same time, 37 kinds of compound reference solutions were added to the blank sample. The results should show that other components in the blank matrix do not interfere with the determination of the above-mentioned analytes.

[0098] Preferably, the verification method of the calibration curve includes the following steps:

[0099] Ba: Prepare the test samples to obtain blank matrix solutions of each dosage form, and take different volumes of mixed reference stock solutions;

[01...

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PUM

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Abstract

The invention discloses a method for determining anti-infection drugs in cosmetics, and relates to the technical field of cosmetic component determination. The problems that the screening range is narrow and the detection method is inaccurate are solved. The method specifically comprises the following steps: preparing a determination material and a determination instrument, preparing a determination standard solution, preparing and determining three blank matrix solutions, determining instrument determination reference conditions including a chromatographic condition and a mass spectrum condition, carrying out parameter verification by adopting a QC sample, screening anti-infection drugs in cosmetics, calculating and establishing a database. The time-of-flight scanning mass spectrometry is adopted, so that the method has high selectivity, accuracy and precision, and has important practical significance for guaranteeing the quality safety of cosmetics and protecting the health of consumers.

Description

technical field [0001] The invention relates to the technical field of cosmetic ingredient determination, in particular to a method for determining anti-infective drugs in cosmetics. Background technique [0002] Acne, also known as acne and pimples, is an inflammatory lesion that occurs in the pilosebaceous glands of the human body and its surrounding tissues. In order to eliminate acne, consumers usually buy and use some cosmetics that claim to have acne-removing / anti-acne effects. However, some manufacturers may illegally add anti-infective drugs to acne-removing cosmetics in order to pursue the good effect of quick sterilization and acne-removing. Studies have shown that anti-infective drugs have cell mutagenicity and animal carcinogenic toxicity. Long-term use of anti-infective drugs can cause serious consequences, which may induce human flora imbalance, cause allergic phenomena such as contact dermatitis, and in severe cases, can cause Visceral damage, mutation of bac...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/72G01N30/04G01N30/06
CPCG01N30/02G01N30/72G01N30/04G01N30/06G01N2030/027G01N2030/042
Inventor 程巧鸳高艳琳颜琳琦陈岑李泽桦王任严俊
Owner ZHEJIANG INST FOR FOOD & DRUG CONTROL
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