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Compound preservative containing capryloyl hydroxamic acid and preparation method thereof

A technology of caprylyl hydroxamic acid and compound preservatives, which is applied in the field of cosmetics, can solve the problems that it is difficult to achieve a balanced antibacterial state of the system, difficult to achieve antibacterial effect, difficult to dissolve and disperse, and achieve stable antibacterial effect and antibacterial effect. Wide range of bacteria, the effect of inhibiting growth and reproduction

Active Publication Date: 2018-09-14
广州艾卓生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, when caprylyl hydroxamic acid is used as a cosmetic preservative, it often faces some technical difficulties and problems: First, compared with traditional antiseptic ingredients, caprylyl hydroxamic acid has relatively weak antibacterial ability, and it is difficult to achieve a good antibacterial effect when used alone. Antibacterial effect; Second, powder caprylyl hydroxamic acid is not easy to dissolve and disperse in cosmetics, and it is difficult to achieve a balanced antibacterial state of the system
However, there is a common problem in the above preservative compositions: due to the addition of a large amount of surfactant, micelles are easy to form, thereby attracting and wrapping caprylyl hydroxamic acid, and finally reducing its antiseptic performance

Method used

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  • Compound preservative containing capryloyl hydroxamic acid and preparation method thereof
  • Compound preservative containing capryloyl hydroxamic acid and preparation method thereof
  • Compound preservative containing capryloyl hydroxamic acid and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] Embodiment 1 A kind of facial mask liquid containing compound preservative

[0024] It is made from the following raw materials and their mass percentages: 2% water-soluble chitosan, 1% loofah water, 8% glycerin, 0.6% compound preservative and the balance sterile water.

[0025] Wherein, the compound preservative is made of the following raw materials and their mass percentages: caprylyl hydroxamic acid 10%, p-hydroxyacetophenone 10%, glucono-δ-lactone 8% and ethylhexylglycerin 72% .

[0026] Preparation:

[0027] S1. Preparation of compound preservatives: Take the corresponding amount of ethylhexylglycerin and glucono-δ-lactone in the reaction kettle, stir and heat to 45°C, add the corresponding amount of caprylyl hydroxamic acid and p-hydroxyphenylethyl ether Ketone, continue to stir until uniform, cool to room temperature, fill, and obtain;

[0028] S2, preparation of facial mask liquid: get corresponding amount of sterile water, add corresponding amount of glyce...

Embodiment 2

[0029] Embodiment 2 A kind of skin lotion containing compound antiseptic

[0030] It is made of the following raw materials and their mass percentages: 10% of plant extracts, 15% of glycerin, 8% of glycerol monostearate, 15% of wheat germ oil, 1% of compound preservatives and the balance of sterile water.

[0031] Wherein, the compound preservative is made of the following raw materials and their mass percentages: caprylyl hydroxamic acid 12%, p-hydroxyacetophenone 8%, glucono-δ-lactone 8% and ethylhexylglycerin 72% .

[0032] Preparation:

[0033] S1, preparation of compound antiseptic: reference example 1;

[0034] S2. Preparation of body lotion: Take the corresponding amount of glycerin monostearate and wheat germ oil and heat to 80°C, stir until completely dissolved to obtain mixture A; heat the corresponding amount of glycerin and sterile water to 90°C, and stir until Completely dissolve to obtain mixture B; mix mixture A and mixture B evenly, stir and emulsify, adju...

Embodiment 3

[0035] Embodiment 3 A kind of hand sanitizer containing compound antiseptic

[0036] Made from the following raw materials and their mass percentages: oil 6%, alkali 3%, absolute ethanol 5.5%, essence 0.2%, pigment 0.2%, fatty acid polyoxyethylene ether sodium sulfate 5%, lauryl dimethyl beet Alkali 3%, compound preservative 0.5% and the balance sterile water.

[0037] Wherein, the compound preservative is made of the following raw materials and their mass percentages: caprylyl hydroxamic acid 10%, p-hydroxyacetophenone 8%, glucono-δ-lactone 6% and ethylhexylglycerin 76% .

[0038] Preparation:

[0039] S1, preparation of compound antiseptic: reference example 1;

[0040] S2. Preparation of hand sanitizer: Take the corresponding amount of oil, alkali, absolute ethanol, essence, pigment, fatty acid polyoxyethylene ether sodium sulfate, lauryl dimethyl betaine, compound preservative and sterile water to mix, Stir and heat to 70-80°C, mix evenly, cool down, and fill and pack ...

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Abstract

The invention belongs to the technical field of cosmetics and particularly relates to a compound preservative containing capryloyl hydroxamic acid and a preparation method thereof. The preservative comprises, by mass, 3-15% of capryloyl hydroxamic acid, 3-15% of p-hydroxyacetophenone, 2-10% of gluconic acid-delta-lactone and 60-90% of ethylhexylglycerin. The compound preservative is simple in component, safe, free of irritation and wide in application range, does not contain a surfactant, can be sufficiently dissolved and dispersed in cosmetic components and has a stable and obvious preservative effect.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a compound preservative containing caprylyl hydroxamic acid and a preparation method thereof. Background technique [0002] Cosmetics are rich in nutrients such as amino acids, proteins, collagen, vitamins, and water. While providing nutrients to the skin, they are also prone to breed bacteria, molds, and other microorganisms. In addition, most cosmetics are non-disposable products. It is easy to cause repeated pollution, resulting in a decline in the quality of cosmetics, such as discoloration of the product, swelling of the paste, damage to the emulsification, mildew spots, organic acids, odors, etc., which will bring discomfort to consumers and even damage consumers in serious cases. health. Therefore, a good antibacterial system is essential for cosmetic products. At present, the preservatives of cosmetics are mainly chemically synthesized ingredients, but amo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/42A61K8/35A61K8/34A61Q19/00
CPCA61K8/345A61K8/35A61K8/42A61K8/498A61K2800/10A61K2800/524A61K2800/592A61Q19/00
Inventor 张军张晓琮
Owner 广州艾卓生物科技股份有限公司
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